The N‐terminal pro‐domain of the kalata B1 cyclotide precursor is intrinsically unstructured [PDF]
Biopolymers, 2016 Cyclotides are plant-derived, gene-encoded, circular peptides with a range of host-defense functions, including insecticidal activity. They also have potential as pharmaceutical scaffolds and understanding their biosynthesis is important to facilitate ...
Norelle L Daly +2 more
exaly +8 more sources
Design, synthesis, structural and functional characterization of novel melanocortin agonists based on the cyclotide kalata B1. [PDF]
J Biol Chem, 2012 Obesity is an increasingly important global health problem that lacks current treatment options. The melanocortin receptor 4 (MC4R) is a target for obesity therapies because its activation triggers appetite suppression and increases energy expenditure ...
Eliasen R +5 more
europepmc +9 more sources
Pharmacokinetic characterization of kalata B1 and related therapeutics built on the cyclotide scaffold [PDF]
International Journal of Pharmaceutics, 2019 Oral activity has been described for cyclotide-containing traditional medicines, and demonstrated for reengineered cyclotides bearing grafted therapeutic epitopes, highlighting their potential for translation to the clinic.
Aaron G Poth, Yen-Hua Huang, Thao T Le
exaly +8 more sources
Analytical Biochemistry, 2005 In this study we have demonstrated the interactions of kalata B1 and its naturally occurring analogue kalata B6 with five model lipid membranes and have analyzed the binding kinetics using surface plasmon resonance.
Hiroshi Kamimori +2 more
exaly +8 more sources
Kalata B1 and Kalata B2 have a surfactant-like activity in phosphatidylethanolomine-containing lipid membranes [PDF]
Langmuir, 2017 Cyclotides are cyclic disulfide-rich peptides that are chemically and thermally stable and possess pharmaceutical and insecticidal properties. The activities reported for cyclotides correlate with their ability to target phosphatidylethanolamine (PE ...
Cranfield, Charles G. +17 more
core +6 more sources
Recombinant Production of The Cyclotide Kalata B1 by Conditional Split Inteins
ChemBioChem, Volume 26, Issue 4, February 16, 2025.This study describes the design, production, and characterization of a novel conditional intein system for the recombinant production of cyclic peptides.
Abdulkadir Yayci +3 more
semanticscholar +6 more sources
Decoding the membrane activity of the cyclotide kalata B1: the importance of phosphatidylethanolamine phospholipids and lipid organization on hemolytic and anti-HIV activities. [PDF]
J Biol Chem, 2011 Cyclotides, a large family of cyclic peptides from plants, have a broad range of biological activities, including insecticidal, cytotoxic, and anti-HIV activities.
Henriques ST +10 more
europepmc +9 more sources
Gly6 of kalata B1 is critical for the selective binding to phosphatidylethanolamine membranes
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2012 The membrane interaction of the cyclotide kalata B1, an all-d-analogue and a single alanine substituted analogue (G6A), was studied by surface plasmon resonance (SPR) and atomic force microscopy (AFM).
Lee, Tzong-Hsien +4 more
core +7 more sources
Scanning mutagenesis identifies residues that improve the long-term stability and insecticidal activity of cyclotide kalata B1. [PDF]
J Biol ChemCyclotides are plant-derived disulfide-rich cyclic peptides that have a natural function in plant defense and potential for use as agricultural pesticides.
Huang YH +7 more
europepmc +6 more sources
The Prototypic Cyclotide Kalata B1 Has a Unique Mechanism of Entering Cells
Chemistry & Biology, 2015 Cyclotides combine the stability of disulfide-rich peptides with the intracellular accessibility of cell-penetrating peptides, giving them outstanding potential as drug scaffolds with an ability to inhibit intracellular protein-protein interactions.
Sani, Marc-Antoine +6 more
core +7 more sources