Results 21 to 30 of about 155,737 (137)

Differential Blood–Brain Barrier Transport and Cell Uptake of Cyclic Peptides In Vivo and In Vitro [PDF]

Pharmaceutics, 2023
The blood–brain barrier (BBB) poses major challenges to drug delivery to the CNS. SFTI-1 and kalata B1 are cyclic cell-penetrating peptides (cCPPs) with high potential to be used as scaffolds for drug delivery.
Erik Melander, Camilla Eriksson, Sara Wellens, Kimia Hosseini, Robert Fredriksson, Fabien Gosselet, Maxime Culot, Ulf Göransson, Margareta Hammarlund-Udenaes, Irena Loryan   +9 more
doaj   +3 more sources

Capped acyclic permutants of the circular protein kalata B1 [PDF]

FEBS Letters, 2004
The cyclotides are a family of head-to-tail cyclized peptides that display exceptionally high stability and a range of biological activities. Acyclic permutants that contain a break in the circular backbone have been reported to be devoid of the ...
Norelle L. Daly, David J. Craik, Simonsen, Shane M., Daly, Norelle L., Craik, David J., Shane M. Simonsen   +5 more
core   +7 more sources

Disulfide mapping of the cyclotide kalata B1 - Chemical proof of the cyclic cystine knot motif [PDF]

Journal of Biological Chemistry, 2003
The cyclotides are a recently discovered family of plant proteins that have the fascinating structural feature of a continuous cyclic backbone and, putatively, a knotted arrangement of their three conserved disulfide bonds. We here show definite chemical
Goransson, Ulf, Craik, David J.
core   +4 more sources

Defining the membrane disruption mechanism of kalata B1 via coarse-grained molecular dynamics simulations. [PDF]

Sci Rep, 2014
Kalata B1 has been demonstrated to have bioactivity relating to membrane disruption. In this study, we conducted coarse-grained molecular dynamics simulations to gain further insight into kB1 bioactivity.
Nawae W, Hannongbua S, Ruengjitchatchawalya M.   +2 more
europepmc   +5 more sources

The role of the cyclic peptide backbone in the anti-HIV activity of the cyclotide kalata B1 [PDF]

FEBS Letters, 2004
The plant cyclotides, the largest known family of circular proteins, have tightly folded structures and a range of biological activities that lend themselves to potential pharmaceutical and agricultural applications.
Daly, Norelle L., Craik, David J., Gustafson, Kirk R.   +2 more
core   +7 more sources

Molecular dynamics simulations support a preference of cyclotide kalata B1 for phosphatidylethanolamine phospholipids

Biochimica Et Biophysica Acta - Biomembranes
Kalata B1 (kB1), a naturally occurring cyclotide has been shown experimentally to bind lipid membranes that contain phosphatidylethanolamine (PE) phospholipids.
Ras Baizureen Roseli, Yen-Hua Huang, Sonia Troeira Henriques   +2 more
exaly   +7 more sources

Lysine-scanning mutagenesis reveals an amendable face of the cyclotide kalata B1 for the optimization of nematocidal activity. [PDF]

J Biol Chem, 2010
Cyclotides are a family of macrocyclic peptides that combine the unique features of a head-to-tail cyclic backbone and a cystine knot motif, the combination of which imparts them with extraordinary stability.
Huang YH, Colgrave ML, Clark RJ, Kotze AC, Craik DJ.   +4 more
europepmc   +8 more sources

The nature inspired peptide [T20K]-kalata B1 induces anti-tumor effects in anaplastic large cell lymphoma

Biomedicine & Pharmacotherapy, 2022
Ribosomally synthesized and post-translationally modified peptides, such as plant cyclotides, are a diverse group of natural products well known as templates in drug discovery and therapeutic lead development. The cyclotide kalata B1 (kB1) has previously
Edtmayer, Sophie (Karl Landsteiner University of Health Sciences), Thell, Kathrin (Medical University of Vienna), Kollmann, Karoline (University of Veterinary Medicine Vienna), Stoiber, Dagmar (Medical University of Vienna / Ludwig Boltzmann Institute for Cancer Research Vienna / Karl Landsteiner University of Health Sciences), Gattringer, Jasmin (Medical University of Vienna), Gruber, Christian W. (Medical University of Vienna), Hellinger, Roland (Medical University of Vienna), Kudweis, Petra (University of Veterinary Medicine Vienna), Moll, Herwig P. (Medical University of Vienna), Lind, Judith (Medical University of Vienna)   +9 more
core   +4 more sources

Thermal, chemical, and enzymatic stability of the cyclotide kalata B1: The importance of the cyclic cystine knot

Biochemistry, 2004
The cyclotides constitute a recently discovered family of plant-derived peptides that have the unusual features of a head-to-tail cyclized backbone and a cystine knot core.
Craik, D. J., Colgrave, M. L.
core   +7 more sources

Anthelminthic activity of the cyclotides (kalata B1 and B2) against schistosome parasites

Peptide Science, 2013
The risk of reduced sensitivity of the human schistosomes to praziquantel has led to efforts to find new therapies. Here the cyclotides kalata B1 (kB1), kalata B2 (kB2), MCoCC-1 and MCoTI-II, cyclic peptides extracted from plants and shown to be potent ...
David Malagón, Duke, Mary, Christian Gray, Mulvenna, Jason, Jason Mulvenna, Knott, Lyn M., Bonnie Botterill, Norelle L. Daly, Malagón, David, David J. Craik, Malcolm K. Jones, Botterill, Bonnie, Donald P. McManus, Gray, Christian, Mary Duke, Jones, Malcolm K., Darren J. Gray, Gray, Darren J., McManus, Donald P., Lovas, Erica, Erica Lovas, Kopp, Steven R., Craik, David J., Steven R. Kopp, Lyn M. Knott, Daly, Norelle L.   +25 more
core   +7 more sources