Results 41 to 50 of about 155,737 (137)
The mode of action of cyclotides: Functional studies of the prototypic cyclotide kalata B1 [PDF]
, 2010 Cyclotides are topologically unique plant-derived cyclic peptides present in plants from Rubiaceae (coffee), Violaceae (violet) and Cucurbitaceae families.
Yen-Hua Huang
core +1 more source
Do Cyclotides bind Lipid Bilayers: Molecular Dynamics Simulations of Kalata B1 and POPC/POPE membranes [PDF]
, 2014 References and Acknowledgements Cyclotides are cyclic antimicrobial peptides (APs) that offer promising features for the development of efficient pharmaceutical therapies.
Neville Y. Forlemu, P. Coppock
semanticscholar +2 more sources
Malaysian applied biology, 2023 The golden apple snail, also known as Siput Gondang Emas in Malaysia, is a serious pest of paddy fields and native aquatic plants throughout Southeast Asia.
N. Md Saad +3 more
semanticscholar +1 more source
Induction and destruction of folding motifs in cyclotides by cyclic cystine knots
Chemical Physics Impact, 2023 Multivariate roles of cyclic cystine knots (CCK) present in cyclotides are well known. More than often this marvellous combination of disulphide linkages embedded in a macrocyclic backbone is seen to induce and stabilize otherwise unfavourable secondary ...
Jayapriya Venkatesan, Durba Roy
doaj +1 more source
Computational Design of Hypothetical New Peptides Based on a Cyclotide Scaffold as HIV gp120 Inhibitor. [PDF]
PLoS ONE, 2015 Cyclotides are a family of triple disulfide cyclic peptides with exceptional resistance to thermal/chemical denaturation and enzymatic degradation. Several cyclotides have been shown to possess anti-HIV activity, including kalata B1 (KB1).
Apiwat Sangphukieo +4 more
doaj +1 more source
Cell Penetrating Peptides: Classification, Mechanisms, Methods of Study, and Applications
ChemMedChem, Volume 18, Issue 17, September 1, 2023., 2023 Cell penetrating peptides constitute a heterogeneous class of peptides with peculiar features that make them particularly well‐suited for the delivery of almost every type of molecule. Due to their versatility, they are becoming increasingly important in various biomedical applications.
Alessandro Gori +4 more
wiley +1 more source
Translational aspect in peptide drug discovery and development: An emerging therapeutic candidate
BioFactors, Volume 49, Issue 2, Page 251-269, March/April 2023., 2023 Abstract In the last two decades, protein–protein interactions (PPIs) have been used as the main target for drug development. However, with larger or superficial binding sites, it has been extremely difficult to disrupt PPIs with small molecules. On the other hand, intracellular PPIs cannot be targeted by antibodies that cannot penetrate the cell ...
Uttpal Anand +4 more
wiley +1 more source
Mutagenesis of cyclotide Cter 27 exemplifies a robust folding strategy for bracelet cyclotides
Peptide Science, Volume 114, Issue 6, November 2022., 2022 Abstract In contrast to Möbius and trypsin inhibitor cyclotides, members of the bracelet subfamily are typically intractable to chemical synthesis and folding. In a significant advance in the field, the bracelet cyclotides ribe 33 and Cter 27 were successfully produced synthetically in moderate yield in a recent study.
Tien T. Dang +5 more
wiley +1 more source
The gift of free money: on the indeterminacy of unconditional cash transfers in western Kenya
Journal of the Royal Anthropological Institute, Volume 28, Issue 1, Page 114-129, March 2022., 2022 Abstract In the area surrounding the western Kenyan market town of Kaleko, almost half of the households targeted by the NGO GiveDirectly refused to participate in an unconditional cash transfer programme. Based on interviews and repeated visits to Kaleko over the last ten years, the article illuminates the reasons for the high refusal rate. Instead of
Mario Schmidt
wiley +1 more source
Plant Biotechnology Journal, Volume 19, Issue 9, Page 1713-1724, September 2021., 2021 Summary Spodoptera frugiperda (fall armyworm) is a notorious pest that threatens maize production worldwide. Current control measures involve the use of chemical insecticides and transgenic maize expressing Bacillus thuringiensis (Bt) toxins. Although additional transgenes have confirmed insecticidal activity, limited research has been conducted in ...
Seung Ho Chung +7 more
wiley +1 more source