Results 61 to 70 of about 155,737 (137)
Plant Biotechnology Journal, Volume 24, Issue 1, Page 31-43, January 2026.Summary In plant molecular farming, recombinant products include traditional protein targets, such as antibodies, antigens, and enzymes, but also increasingly refers to high‐value peptides, and small molecules produced by heterologous enzymatic pathways.
Maxim D. Harding, Frank Sainsbury
wiley +1 more source
Advances in the Role of Antimicrobial Peptides in the Management of Sexually Transmitted Infections
Journal of Clinical Laboratory Analysis, Volume 39, Issue 11, June 2025.The article reviews recent advancements in the use of antimicrobial peptides (AMPs) for the treatment and prevention of sexually transmitted infections (STIs), with a particular focus on research progress in combating infections such as gonorrhea, HIV, HSV, and Chlamydia, as well as the challenges and future directions in this field.
Shuangwen Xiao +4 more
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Review on the o‐Aminoaniline Moiety in Peptide and Protein Chemistry
ChemBioChem, Volume 26, Issue 9, May 5, 2025.The ability to prepare functional peptides and protein molecules is essential to understand fundamental biological processes and develop novel therapeutics for numerous diseases. In this review, Hong et al. document the development of o‐aminoaniline derivatives for chemical protein synthesis, peptide C‐terminus diversification, and cyclic peptide ...
Ziyong Z. Hong
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Acyclic permutants of naturally occurring cyclic proteins - Characterization of cystine knot and beta-sheet formation in the macrocyclic polypeptide kalata B1 [PDF]
, 2000 Kalata B1 is a prototypic member of the unique cyclotide family of macrocyclic polypeptides in which the major structural features are a circular peptide backbone, a triple stranded beta-sheet, and a cystine knot arrangement of three disulfide bonds. The
Daly, NL +3 more
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Display Technologies for Expanding the Pharmaceutical Applications of Cyclotides
Israel Journal of Chemistry, Volume 64, Issue 8-9, September 2024.Abstract Cyclotides are ultra‐stable peptides originally discovered in plants based on their medicinal applications. Their natural function is as host defence agents. They are amenable to chemical synthesis for use as scaffolds for drug design applications.
Jing Xie +4 more
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Protein Grafting Techniques: From Peptide Epitopes to Lasso‐Grafted Neobiologics
ChemPlusChem, Volume 89, Issue 8, August 2024.The idea of grafting small peptide pharmacophores onto larger protein scaffolds, thus harvesting the advantages of both, has given rise to a variety of protein engineering strategies that are reviewed herein. We also describe our own “Lasso‐Grafting” approach, which combines traditional grafting concepts with mRNA display to streamline the production ...
Mikio Imai, Kilian Colas, Hiroaki Suga
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, 2022 Journal of the International AIDS Society, Volume 25, Issue S3, August 2022.
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Molecular farming for sustainable production of clinical‐grade antimicrobial peptides
Plant Biotechnology Journal, Volume 22, Issue 8, Page 2282-2300, August 2024.Summary Antimicrobial peptides (AMPs) are emerging as next‐generation therapeutics due to their broad‐spectrum activity against drug‐resistant bacterial strains and their ability to eradicate biofilms, modulate immune responses, exert anti‐inflammatory effects and improve disease management. They are produced through solid‐phase peptide synthesis or in
Shahid Chaudhary +2 more
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Structure and Activity of Reconstructed Pseudo‐Ancestral Cyclotides
ChemMedChem, Volume 19, Issue 14, July 15, 2024.Ancestral sequence reconstruction was used to predict two ancestral cyclotides, Ancy‐m and Ancy‐b. These two predicted ancestors maintained their stability and activities. Meanwhile, Ancy‐b had an improved folding yield over the prototypical bracelet cyclotide.
Zhihao Jiang +4 more
wiley +1 more source
, 2016 The cyclotides constitute a recently discovered family of plant-derived peptides that have the unusual features of a head-to-tail cyclized backbone and a cystine knot core.
David J. Craik (13753) +1 more
core +1 more source