Results 71 to 80 of about 155,737 (137)

Antimicrobial peptides for novel antiviral strategies in the current post‐COVID‐19 pandemic

Journal of Peptide Science, Volume 30, Issue 1, January 2024.
This review describes the main physicochemical characteristics of antimicrobial peptides, with particular focus on peptides derived from amphibian skin. Summarizing the various antiviral activities of these peptides and the underlying mechanism, this review emphasizes the high potential of these small molecules for the development of new antiviral ...
Maria Rosa Loffredo, Lucia Nencioni, Maria Luisa Mangoni, Bruno Casciaro   +3 more
wiley   +1 more source

Fixed stoichiometry analysis of kalata B1, the prototypical cyclotide, assuming a monomer-tetramer equilibrium.

, 2013
NMRdyn was used to perform a search over different association constants. The overall Akaike's Information Criteria (AIC) score was used to judge the goodness of the fit, with the aim of obtaining the minimum AIC score.
Conan K. Wang (198148), David J. Craik (13753), Horst Joachim Schirra (271310)   +2 more
core   +1 more source

Biosynthesis of the cyclotide Kalata B1 using protein splicing tools

, 2005
Cyclotides are a new emerging family of large cyclic polypeptides ({approx}30 residues long) that share a disulfide-stabilized core (3 disulfide bonds) with an unusual knotted structure (Fig. 1A) [1].
Camarero, J. A., Kimura, R., Krishnan, K.   +2 more
core  

Orally active peptidic bradykinin B1 receptor antagonists engineered from a cyclotide scaffold for inflammatory pain treatment

, 2012
Edible: By grafting natural peptide antagonists onto the cyclotide kalata B1, orally active peptides were engineered, which are potentially useful therapeutics for the treatment of inflammatory pain.
Wong, Chi-Hang., Rowlands, Dewi K., Nguyen, Giang K. T., Wong, Clarence T. T., Li, Hoi-Yeung, Tam, James P., Lo, Theodore W. C.   +6 more
core   +1 more source

Generation of transgenic rice expressing cyclotide precursor Oldenlandia affinis kalata B1 protein [PDF]

, 2017
Golden apple snail (Pomacea canaliculata) is a devastating pest on rice that causes heavy economic losses in South East Asia. In this study, we transformed mature seed-derived rice callus with plasmid containing Oldenlandia affinis kalata B1 (Oak1) gene ...
Lai, Kok Song, Lim, Yi Yi
core  

Chemical Synthesis and Folding Pathways of Large Cyclic Polypeptides:  Studies of the Cystine Knot Polypeptide Kalata B1^†

, 2016
Kalata B1 is a member of a new family of polypeptides, isolated from plants, which have a cystine knot structure embedded within an amide-cyclized backbone.
Paul F. Alewood (1520788), Norelle L. Daly (457317), David J. Craik (13753), Steve Love (2950989)   +3 more
core   +1 more source

Predicted membrane binding modes (left) and lipophilicity profiles (right) for kalata B1 (A), cycloviolacin O2 (B) and kalata B8 (C) in their native cyclic conformations and in hypothetically unfolded conformations.

, 2014
The outer phosphate layer of a phospholipid membrane is represented by a red line in each case. Strained backbone regions with little structural mobility are indicated in blue. Backbone regions with a defined secondary structure are colored in yellow and
Sungkyu Park (544757), Ulf Göransson (544759), Adam A. Strömstedt (544758)   +2 more
core   +1 more source

Discovery, isolation and structural characterization of cyclotides from Viola sumatrana miq [PDF]

, 2016
Cyclotides are cyclic peptides from plants in the Violaceae, Rubiaceae, Fabaceae, Cucurbitaceae, and Solanaceae families. They are sparsely distributed in most of these families, but appear to be ubiquitous in the Violaceae, having been found in every ...
Colgrave, Michelle L., Niyomploy, Ploypat, Chan, Lai Yue, Craik, David J., Sangvanich, Polkit, Poth, Aaron G.   +5 more
core   +1 more source

The role of conserved Glu residue on cyclotide stability and activity: A structural and functional study of kalata B12, a naturally occurring Glu to Asp mutant

, 2011
Cyclotides are a family of plant defense proteins with a unique cyclic backbone and cystine knot. Their remarkable stability under harsh thermal, enzymatic, and chemical conditions, combined with their range of bioactivities, including anti-HIV activity,
Harvey, Peta J., Conan K. L. Wang, K. Johan Rosengren, Clark, Richard J., David J. Craik, Rosengren, K. Johan, Masa Cemazar, Peta J. Harvey, Craik, David J., Cemazar, Masa, Richard J. Clark, Wang, Conan K. L.   +11 more
core   +1 more source

Isolation, solution structure, and insecticidal activity of Kalata B2, a circular protein with a twist: Do Mobius strips exist in nature?

, 2005
A large number of macrocyclic miniproteins with diverse biological activities have been isolated from the Rubiaceae, Violaceae, and Cucurbitaceae plant families in recent years.
Scanlon, Martin J., Norman, David G., Stevens, Jackie, Anderson, Marilyn A., Rosengren, K. Johan, Waine, Clement, Plan, Manuel, Daly, Norelle L., Craik, David J., Jennings, Cameron V.   +9 more
core   +1 more source