Results 81 to 90 of about 155,737 (137)

Disulfide mapping of the cyclotide kalata B1. Chemical proof of the cystic cystine knot motif.

The Journal of biological chemistry, 2003
The cyclotides are a recently discovered family of plant proteins that have the fascinating structural feature of a continuous cyclic backbone and, putatively, a knotted arrangement of their three conserved disulfide bonds. We here show definite chemical proof of the I-IV, II-V, III-VI knotted disulfide connectivity of the prototypic cyclotide kalata ...
Goransson, Ulf, Craik, David J.
openaire   +4 more sources

Linearization of a naturally occurring circular protein maintains structure but eliminates hemolytic activity

, 2003
Cyclotides are a recently discovered family of disulfide rich proteins from plants that contain a circular protein backbone. They are exceptionally stable, as exemplified by their use in native medicine of the prototypic cyclotide kalata B1.
Sando, L., Clark, R. J., Daly, N. L., Craik, D. J., Barry, D. G.   +4 more
core   +1 more source

Structural and functional characterization of chimeric cyclotides from the Möbius and trypsin inhibitor subfamilies

, 2017
Cyclotides are plant-derived host defense peptides displaying exceptional stability due to their cyclic cystine knot comprising three intertwined disulfide bonds and a cyclic backbone. Their six conserved cysteine residues are separated by backbone loops
Schroeder, Christina I., Swedberg, Joakim E., Henriques, Sonia Troeira, Huang, Yen-Hua, Craik, David J., Abdul Ghani, Hafiza   +5 more
core   +1 more source

Structural plasticity of the cyclic-cystine-knot framework: implications for biological activity and drug design

, 2006
The cyclotide family of plant proteins is of interest because of their unique topology, which combines a head-to-tail cyclic backbone with an embedded cystine knot, and because their-remarkable chemical and biological properties make them ideal ...
Clark, R. J., Daly, N. L., Craik, D. J.
core   +1 more source

Exploring Immune Modulatory Effects of Cyclotide-Enriched Viola tricolor Preparations. [PDF]

Planta Med, 2023
Retzl B, Zimmermann-Klemd AM, Winker M, Nicolay S, Gründemann C, Gruber CW.   +5 more
europepmc   +1 more source

Produktion von Cyclotiden in pflanzlichen Zellkulturen von Oldenlandia affinis

, 2009
Within the frame of this research work, a process for production of cyclotides by plant cell cultures could be established. Cyclotides are possible agents for pharmaceutical industry, due to their high stability and their bioactive effects.
Seydel, Peter
core  

Biosynthesis of the Cyclotide Kalata B1 using a Protein Splicing Unit

, 2005
Cyclotides are a newly emerging family of large backbone cyclic polypeptides ({approx}30 residues long) characterized by a disulfide-stabilized core (3 disulfide bonds) with an unusual knotted structure.
Tran, A T, Kimura, R H, Camarero, J A
core  

Using the Cyclotide Scaffold for Targeting Biomolecular Interactions in Drug Development. [PDF]

Molecules, 2022
Jacob B, Vogelaar A, Cadenas E, Camarero JA.   +3 more
europepmc   +1 more source

Cyclotides as novel plant-derived scaffolds for orally active cyclic peptide therapeutics. [PDF]

Mol Cells
Hyun Y.
europepmc   +1 more source

Plant-based production of an orally active cyclotide for the treatment of multiple sclerosis. [PDF]

Transgenic Res, 2023
Jackson MA, Xie J, Nguyen LTT, Wang X, Yap K, Harvey PJ, Gilding EK, Craik DJ.   +7 more
europepmc   +1 more source