Results 51 to 60 of about 155,737 (137)

Host-Defense Activities of Cyclotides

Toxins, 2012
Cyclotides are plant mini-proteins whose natural function is thought to be to protect plants from pest or pathogens, particularly insect pests. They are approximately 30 amino acids in size and are characterized by a cyclic peptide backbone and a cystine
David J. Craik
doaj   +1 more source

How Does the Sweet Violet (Viola odorata L.) Fight Pathogens and Pests – Cyclotides as a Comprehensive Plant Host Defense System

Frontiers in Plant Science, 2018
Cyclotides are cyclic plant polypeptides of 27–37 amino acid residues. They have been extensively studied in bioengineering and drug development contexts. However, less is known about the relevance of cyclotides for the plants producing them.
Blazej Slazak, Blazej Slazak, Małgorzata Kapusta, Adam A. Strömstedt, Aneta Słomka, Marta Krychowiak, Mohammadreza Shariatgorji, Per E. Andrén, Jerzy Bohdanowicz, Elżbieta Kuta, Ulf Göransson   +10 more
doaj   +1 more source

Identification of candidates for cyclotide biosynthesis and cyclisation by expressed sequence tag analysis of Oldenlandia affinis

BMC Genomics, 2010
Background Cyclotides are a family of circular peptides that exhibit a range of biological activities, including anti-bacterial, cytotoxic, anti-HIV activities, and are proposed to function in plant defence.
Suda Jan, Kaas Quentin, McCallum Emily J, Qin Qiaoping, Saska Ivana, Craik David J, Mylne Joshua S   +6 more
doaj   +1 more source

Chemical Proteomics for Target Discovery of Head-to-Tail Cyclized Mini-Proteins

Frontiers in Chemistry, 2017
Target deconvolution is one of the most challenging tasks in drug discovery, but a key step in drug development. In contrast to small molecules, there is a lack of validated and robust methodologies for target elucidation of peptides.
Roland Hellinger, Kathrin Thell, Mina Vasileva, Taj Muhammad, Sunithi Gunasekera, Daniel Kümmel, Ulf Göransson, Christian W. Becker, Christian W. Gruber, Christian W. Gruber   +9 more
doaj   +1 more source

Engineering agatoxin, a cystine-knot peptide from spider venom, as a molecular probe for in vivo tumor imaging.

PLoS ONE, 2013
BackgroundCystine-knot miniproteins, also known as knottins, have shown great potential as molecular scaffolds for the development of targeted therapeutics and diagnostic agents.
Sarah J Moore, Cheuk Lun Leung, Heidi K Norton, Jennifer R Cochran   +3 more
doaj   +1 more source

Biosynthesis of the Cyclotide Kalata B1 using Protein Splicing Tools [PDF]

, 2010
Cyclotides are a new emerging family of large cyclic polypeptides ({approx}30 residues long) that share a disulfide-stabilized core (3 disulfide bonds) with an unusual knotted structure (Fig. 1A) [1]. Cyclotides contrast with other circular polypeptides in that they have a highly defined three-dimensional structure, and despite their small size, can be
Kimura, R., Krishnan, K., Camarero, J. A.   +2 more
openaire   +1 more source

Structure of kalata B1 and cyclotide mutants.

, 2013
The structure of kalata B1 is shown in cartoon form (A). The six conserved cysteines are labeled with Roman numerals and the cystine knot disulfide connectivity (CI-CIV, CII-CV and CIII-CVI) is indicated.
Karin Lengen (426885), Yen-Hua Huang (409275), Manuel Garcia-Käufer (426886), Kathrin Thell (426884), Roman Huber (426887), Christian W. Gruber (176571), Carsten Gründemann (426883), David J. Craik (13753), Gernot Schabbauer (426813)   +8 more
core   +1 more source

Cyclic Peptides for Drug Development

Angewandte Chemie, Volume 136, Issue 3, January 15, 2024.
Cyclic peptides combine a number of favorable properties that make them attractive for drug development. Today, more than 40 therapeutics based on cyclic peptides are in use, and new, powerful technologies for their development suggest that this number could grow rapidly.
Xinjian Ji, Alexander L. Nielsen, Christian Heinis   +2 more
wiley   +2 more sources

Trypsin inhibition by macrocyclic and open-chain variants of the squash inhibitor MCoTI-II [PDF]

, 2005
MCoTl-I and MCoTl-II from the seeds of Momordica cochinchinensis are inhibitors of trypsin-like proteases and the only known members of the large family of squash inhibitors that are cyclic and contain an additional loop connecting the amino- and the ...
Avrutina, Olga, Gabrijelcic-Geiger, Dusica, Le Nguyen, Dung, Schmoldt, H. U., Sommerhoff, Christian P., Kolmar, Harald, Gabrijelcic-Geiger, D., Le Nguyen, D., Schmoldt, Hans-Ulrich, Diederichsen, Ulf   +9 more
core   +1 more source

Protein Structure Determination by Racemic and Quasi‐Racemic X‐Ray Crystallography

ChemBioChem, Volume 27, Issue 4, 25 February 2026.
Racemic mixtures of protein enantiomers facilitate formation of diffraction‐quality crystals in centrosymmetric space groups that have quantized phases which simplify structure solution. Quasi‐racemic mixtures of a protein and its mirror image isomorph similarly facilitate formation of highly ordered crystals.
Stephen B. H. Kent
wiley   +1 more source