How Does the Sweet Violet (Viola odorata L.) Fight Pathogens and Pests – Cyclotides as a Comprehensive Plant Host Defense System [PDF]
Frontiers in Plant Science, 2018 Cyclotides are cyclic plant polypeptides of 27–37 amino acid residues. They have been extensively studied in bioengineering and drug development contexts. However, less is known about the relevance of cyclotides for the plants producing them.
Blazej Slazak +10 more
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Do plant cyclotides have potential as immunosuppressant peptides? [PDF]
J Nat Prod, 2012 Cyclotides are an abundant and diverse group of ribosomally synthesized plant peptides containing a cyclic cystine-knotted structure that confers them with remarkable stability. They are explored for their distribution in plants, although little is known
Gründemann C +3 more
europepmc +8 more sources
Distribution of circular proteins in plants: large-scale mapping of cyclotides in the Violaceae [PDF]
Frontiers in Plant Science, 2015 During the last decade there has been increasing interest in small circular proteins found in plants of the violet family (Violaceae). These so-called cyclotides consist of a circular chain of approximately 30 amino acids, including six cysteines forming
Robert eBurman +7 more
doaj +8 more sources
Cyclotides as novel plant-derived scaffolds for orally active cyclic peptide therapeutics [PDF]
Molecules and Cells: Cyclotides are a group of plant-derived small peptides, characterized by a head-to-tail cyclic backbone and 3 conserved cysteine knots. The unique structure endows cyclotides with exceptional chemical stability and intrinsic cell-penetrating capacities,
Youbong Hyun
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Immunolocalization of cyclotides in plant cells, tissues and organ supports their role in host defense [PDF]
Planta, 2016 The distribution of cyclotides was visualized in plant cells, tissues and organs using immunohistochemistry. Finding of cyclotides in tissues potentially vulnerable to pathogen attacks supports their role as defense molecules.
Blażej Slazak +2 more
exaly +2 more sources
Host-Defense Activities of Cyclotides
Toxins, 2012 Cyclotides are plant mini-proteins whose natural function is thought to be to protect plants from pest or pathogens, particularly insect pests. They are approximately 30 amino acids in size and are characterized by a cyclic peptide backbone and a cystine
David J. Craik
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A Comprehensive Review on the Anticancer Activity of Plant Peptides and Their Mechanisms of Action [PDF]
FoodsPlant-derived peptides have become one of the most promising classes of compounds in cancer research due to their specificity, safety, and different therapeutic actions.
Tianyu Hou +5 more
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Journal of Evidence-Based Complementary & Alternative Medicine, 2012 In recent years, a number of peptides containing a cyclic structural fold have been described. Among them, the cyclotides family was widely reported in different plant tissues, being composed of small cyclic peptides containing 6 conserved cysteine ...
Michelle F. S. Pinto +6 more
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The involvement of cyclotides in the heavy metal tolerance of Viola spp. [PDF]
Scientific ReportsThe Violaceae family is rich in metal-tolerant species and species producing cyclic peptides (cyclotides) that are linked to the resistance to biotic factors.
Klaudia Sychta +6 more
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Comprehensive Mapping of Cyclotides from Viola philippica by Using Mass Spectrometry-Based Strategy [PDF]
MoleculesCyclotides are plant cyclic peptides with exceptional stability and diverse bioactivity, making them promising candidates for biomedical applications. Therefore, the study of cyclotides has attracted increasing attention in recent years.
Liyan Yu +6 more
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