Results 21 to 30 of about 1,205 (188)

Computational screening of AI-derived cyclotides as putative VEGFR2 binders for wound-site angiogenesis [PDF]

Scientific Reports
Chronic wounds represent a longstanding clinical problem due to impaired angiogenesis due to insufficient activation of vascular endothelial growth factor receptor 2 (VEGFR2).
Özlem Karaca Ocak, Nouman Ali
doaj   +2 more sources

Isolation and characterization of cytotoxic cyclotides from Viola tricolor

Peptides, 2010
Many plants of the Violaceae plant family have been used in traditional remedies, and these plants often contain cyclotides, a particular type of plant cyclopeptide that is distinguished by a cyclic cystine knot motif.
Jun Tang, Conan K Wang, Wenyan Xu
exaly   +2 more sources

Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design. [PDF]

Proc Natl Acad Sci U S A, 2013
Cyclotides are plant peptides comprising a circular backbone and three conserved disulfide bonds that confer them with exceptional stability. They were originally discovered in Oldenlandia affinis based on their use in traditional African medicine to ...
Koehbach J, O'Brien M, Muttenthaler M, Miazzo M, Akcan M, Elliott AG, Daly NL, Harvey PJ, Arrowsmith S, Gunasekera S, Smith TJ, Wray S, Göransson U, Dawson PE, Craik DJ, Freissmuth M, Gruber CW.   +16 more
europepmc   +2 more sources

Isolation and characterization of cytotoxic cyclotides from Viola philippica

Peptides, 2011
Cyclotides are a large family of plant peptides characterized by a macrocyclic backbone and knotted arrangement of three disulfide bonds. This unique structure renders cyclotides exceptionally stable to thermal, chemical and enzymatic treatments.
Lai Yue Chan, Norelle L Daly, David J Craik   +2 more
exaly   +2 more sources

Cyclotides: disulfide-rich peptide toxins in plants [PDF]

Toxicon, 2019
Cyclotides are a plant-derived family of peptides that comprise approximately 30 amino acid residues, a cyclic backbone and a cystine knot. Due to their unique structure, cyclotides are exceptionally stable to heat or proteolytic degradation and are ...
Du, Qingdan, Huang, Yen-Hua, Craik, David J.   +2 more
core   +6 more sources

Insecticidal plant cyclotides and related cystine knot toxins

Toxicon, 2007
Cyclotides are small disulphide-rich peptides found in plants from the violet (Violaceae), coffee (Rubiaceae) and cucurbit (Cucurbitaceae) families. They have the distinguishing structural features of a macrocyclic peptide backbone and a cystine knot ...
Craik, D. J, Cemazar, M., Anderson, MA, Gruber, C. W   +3 more
core   +6 more sources

The Influence of Plant Stress Hormones and Biotic Elicitors on Cyclotide Production in Viola uliginosa Cell Suspension Cultures

Plants, 2022
Cyclotides are macrocycle peptides produced by plants from several families, including Violaceae. These compounds have the potential for applications in medicine, bioengineering and crop protection thanks to their multiple biological activities.
Blazej Slazak, Aleksandra Jędrzejska, Bogna Badyra, Reza Shariatgorji, Anna Nilsson, Per E. Andrén, Ulf Göransson   +6 more
doaj   +1 more source

In vitro Inhibition of HIV-1 by Cyclotide-Enriched Extracts of Viola tricolor

Frontiers in Pharmacology, 2022
Since viral infectious diseases continue to be a global health threat, new antiviral drugs are urgently needed. A unique class of therapeutic compounds are antimicrobial peptides (AMPs). They can be found in humans, bacteria and plants.
Carina Conzelmann, Edin Muratspahić, Nataša Tomašević, Jan Münch, Christian W. Gruber   +4 more
doaj   +1 more source

Plant-Derived Cyclotides Modulate κ-Opioid Receptor Signaling [PDF]

Journal of Natural Products, 2021
Cyclotides are plant-derived disulfide-rich peptides comprising a cyclic cystine knot, which confers remarkable stability against thermal, proteolytic, and chemical degradation. They represent an emerging class of G protein-coupled receptor (GPCR) ligands.
Edin Muratspahić, Nataša Tomašević, Shahrooz Nasrollahi-Shirazi, Jasmin Gattringer, Fabiola Susanna Emser, Michael Freissmuth, Christian W. Gruber   +6 more
openaire   +2 more sources

Effects of a plant cyclotide on conformational dynamics and destabilization of β-amyloid fibrils through molecular dynamics simulations

Frontiers in Molecular Biosciences, 2022
Aggregation of β-amyloid (Aβ) peptide is one of the hallmarks of Alzheimer’s disease (AD) which results in chronic and progressive neurodegeneration of the brain.
Neha V. Kalmankar, Bhuvaneshwari Rajendrakumar Gehi, Ramanathan Sowdhamini, Ramanathan Sowdhamini, Ramanathan Sowdhamini   +4 more
doaj   +1 more source