Results 41 to 50 of about 1,205 (188)
Plant cyclotides disrupt epithelial cells in the midgut of lepidopteran larvae. [PDF]
Proc Natl Acad Sci U S A, 2008 Several members of the Rubiaceae and Violaceae plant families produce a series of cyclotides or macrocyclic peptides of 28–37 aa with an embedded cystine knot. The cyclic peptide backbone together with the knotted and strongly braced structure confers exceptional chemical and biological stability that has attracted attention for potential ...
Barbeta BL +4 more
europepmc +7 more sources
Genome-wide in silico and in vitro mining to develop a novel cyclotide-based marker system in plants
Biotechnology & Biotechnological Equipment, 2023 Cyclotides are cysteine-rich cyclic peptides that have various activities and applications. Mining at the whole-genome scale facilitates the profiling and development of cyclotide-based markers. However, the characterization of cyclotide subfamilies at a
Arwa Salah +3 more
doaj +1 more source
Discovery of insecticidal cyclotides from the African plants Allexis batangae and Allexis obanensis
Industrial Crops and ProductsCyclotides are plant-derived cyclic peptides recognized for their crucial role in host defense against insects and fungal pathogens. They are characterized by an ultra-stable head-to-tail cyclic backbone and a cystine knot formed by three conserved ...
Negin Khatibi +7 more
doaj +1 more source
BMC Genomics, 2010 Background Cyclotides are a family of circular peptides that exhibit a range of biological activities, including anti-bacterial, cytotoxic, anti-HIV activities, and are proposed to function in plant defence.
Suda Jan +6 more
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, 2015 It has been 20 years since the cyclic cystine-knotted compounds, called cyclotides, tied our knot with the violets. This chapter, above all, is a lucid summary of the twists, turns, knots, and rings in the relationship that followed.
Ulf Göransson +5 more
core +1 more source
Frontiers in Plant Science, 2019 Viola is a large genus with worldwide distribution and many traits not currently exemplified in model plants including unique breeding systems and the production of cyclotides. Here we report de novo genome assembly and transcriptomic analyses of the non-
Anne L. Sternberger +7 more
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Understanding the Diversity and Distribution of Cyclotides from Plants of Varied Genetic Origin [PDF]
Journal of Natural Products, 2017 Cyclotides are a large family of naturally occurring plant-derived macrocyclic cystine-knot peptides, with more than 400 having been identified in species from the Violaceae, Rubiaceae, Cucurbitaceae, Fabaceae, and Solanaceae families. Nevertheless, their specialized distribution within the plant kingdom remains poorly understood.
Anjaneya S. Ravipati +7 more
openaire +4 more sources
Cyclotides Suppress Human T-Lymphocyte Proliferation by an Interleukin 2-Dependent Mechanism.
PLoS ONE, 2013 Cyclotides are a diverse and abundant group of ribosomally synthesized plant peptides containing a unique cyclic cystine-knotted topology that confers them with remarkable stability. Kalata B1, a representative member of this family of mini-proteins, has
Carsten Gründemann +8 more
doaj +1 more source
Discovery of the cyclotide caripe 11 as a ligand of the cholecystokinin-2 receptor
Scientific Reports, 2022 The cholecystokinin-2 receptor (CCK2R) is a G protein-coupled receptor (GPCR) that is expressed in peripheral tissues and the central nervous system and constitutes a promising target for drug development in several diseases, such as gastrointestinal ...
Mohammad Sadegh Taghizadeh +8 more
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Química Nova, 2009 Natural peptides are outstanding as the most promising macromolecules in the search for new drugs, especially those of cyclic nature. The higher plants revealed a very peculiar composition of their cyclic peptides, which distinguish themselves by a "head-
Douglas Gatte Picchi +4 more
doaj +1 more source