Results 61 to 70 of about 1,205 (188)

Proposed EU NGT legislation in light of plant genetic variation

Plant Biotechnology Journal, Volume 23, Issue 10, Page 4261-4270, October 2025.
Summary The European Commission (EC) proposal for New Genomic Techniques (NGTs) of July 2023 specifies that Category 1 NGT (NGT1) plants, which are considered equivalent to conventional plants, that is those obtainable by conventional plant breeding or mutagenesis, may differ from the recipient or parental plant by no more than 20 insertions, which ...
Alan H. Schulman, Frank Hartung, Marinus J.M. Smulders, Jens F. Sundström, Ralf Wilhelm, Odd Arne Rognli, Karin Metzlaff   +6 more
wiley   +1 more source

Plant-based production of an orally active cyclotide for the treatment of multiple sclerosis

Transgenic Research, 2023
AbstractMultiple sclerosis (MS) is a debilitating disease that requires prolonged treatment with often severe side effects. One experimental MS therapeutic currently under development is a single amino acid mutant of a plant peptide termed kalata B1, of the cyclotide family.
Mark A. Jackson, Jing Xie, Linh T. T. Nguyen, Xiaohan Wang, Kuok Yap, Peta J. Harvey, Edward K. Gilding, David J. Craik   +7 more
openaire   +4 more sources

Exploring Plant α‐Amylase Inhibitors: Mechanisms and Potential Application for Insect Pest Control

Biotechnology Journal, Volume 20, Issue 8, August 2025.
Graphical Abstract and Lay Summary In this study, we address the importance of α‐amylases in insect pests, the possible biochemical role of α‐amylase inhibitors in plant resistance to insect pests, the molecular relationships between plant α‐amylase inhibitors and insect α‐amylases, and the biotechnological potential of proteinaceous α‐amylase ...
Marcos Fernando Basso, Arnubio Valencia‐Jiménez, Fabrizio Lo Celso, Isabel Rodrigues Gerhardt, Thomas Joseph V. Higgins, Maria Fatima Grossi‐de‐Sa   +5 more
wiley   +1 more source

Cyclotides prediction in Leptopetalum biflorum based on de novo transcriptome assembly and annotation

Journal of Holistic Integrative Pharmacy
Objective: There is a scarcity of transcriptome sequencing data available for the Leptopetalum biflorum, and numerous cyclotides remain undiscovered.
Xi Liu, Linlin Cai, Zhiming Zhou, Peiming Huang, Zhonglu Ren   +4 more
doaj   +1 more source

Discovery of Cyclotides in the Fabaceae Plant Family Provides New Insights into the Cyclization, Evolution, and Distribution of Circular Proteins

, 2016
Cyclotides are plant proteins whose defining struc-tural features are a head-to-tail cyclized backbone and three interlocking disulfide bonds, which in combination are known as a cyclic cystine knot.
Marilyn A. Anderson (2208346), Norelle L. Daly (457317), David J. Craik (13753), Aaron G. Poth (1478464), Reynold Philip (2208349), Michelle L. Colgrave (368112), Bomai Kerenga (2208352)   +6 more
core   +1 more source

Decoding small peptides: Regulators of plant growth and stress resilience

Journal of Integrative Plant Biology, Volume 67, Issue 3, Page 596-631, March 2025.
This review explores how small peptides act as key regulators of plant growth, development, and stress responses. It highlights recent advances in small peptide identification and their roles in enhancing plant resilience to environmental challenges, offering new perspectives for improving crop productivity.
Fei Xiao, Huapeng Zhou, Honghui Lin
wiley   +1 more source

Discovery of cyclotides in the fabaceae plant family provides new insights into the cyclization, evolution, and distribution of circular proteins

, 2011
Cyclotides are plant proteins whose defining struc-tural features are a head-to-tail cyclized backbone and three interlocking disulfide bonds, which in combination are known as a cyclic cystine knot.
Michelle L. Colgrave, Colgrave, Michelle L., Craik, David J., Marilyn A. Anderson, Poth, Aaron G., Philip, Reynold, Aaron G. Poth, Anderson, Marilyn A., Norelle L. Daly, David J. Craik, Kerenga, Bomai, Reynold Philip, Daly, Norelle L., Bomai Kerenga   +13 more
core   +1 more source

Recombinant Production of The Cyclotide Kalata B1 by Conditional Split Inteins

ChemBioChem, Volume 26, Issue 4, February 16, 2025.
A workflow to generate cyclic peptides from easily obtainable precursor proteins was established. The peptide is embedded in a split intein system that can be expressed in E. coli and purified via IMAC. Simply mixing the two precursor proteins starts conversion at will, yielding cyclic peptides.
Abdulkadir Yayci, Yen‐Hua Huang, Peta J. Harvey, David J. Craik   +3 more
wiley   +1 more source

Discovery, structure, function, and applications of cyclotides: circular proteins from plants [PDF]

Journal of Experimental Botany, 2016
Cyclotides are plant-derived cyclic peptides that have a head-to-tail cyclic backbone and three conserved disulphide bonds that form a cyclic cystine knot motif. They occur in plants from the Violaceae, Rubiaceae, Cucurbitaceae, Fabaceae, and Solanaceae families, typically with 10-100 cyclotides in a given plant species, in a wide range of tissues ...
Joachim Weidmann, David J. Craik
openaire   +5 more sources

Harnessing cyclotides to design and develop novel peptide GPCR ligands

, 2020
Cyclotides are plant-derived cyclic, disulfide-rich peptides with a unique cyclic cystine knot topology that confers them with remarkable structural stability and resistance to proteolytic degradation.
Muratspahić, Edin, Gruber, Christian W., Craik, David J., Koehbach, Johannes   +3 more
core   +1 more source