Results 51 to 60 of about 1,205 (188)
Do Plant Cyclotides Have Potential As Immunosuppressant Peptides?
, 2016 Cyclotides are an abundant and diverse group of ribosomally synthesized plant peptides containing a cyclic cystine-knotted structure that confers them with remarkable stability. They are explored for their distribution in plants, although little is known
Christian W Gruber (2110414) +3 more
core +1 more source
Chemical Proteomics for Target Discovery of Head-to-Tail Cyclized Mini-Proteins
Frontiers in Chemistry, 2017 Target deconvolution is one of the most challenging tasks in drug discovery, but a key step in drug development. In contrast to small molecules, there is a lack of validated and robust methodologies for target elucidation of peptides.
Roland Hellinger +9 more
doaj +1 more source
Traditional Persian topical medications for gastrointestinal diseases [PDF]
Iranian Journal of Basic Medical Sciences, 2017 Drug delivery across the skin is used for several millennia to ease gastrointestinal (GI) ailments in Traditional Persian Medicine (TPM). TPM topical remedies are generally being applied on the stomach, lower abdomen, lower back and liver to alleviate GI
Laleh Dehghani Tafti +3 more
doaj +1 more source
ChemBioChem, Volume 27, Issue 8, April 2026.Split intein mediated circular ligation of peptide and proteins mediated selection of 7‐mer cyclic peptide library for binding Amyloid‐β oligomers identified cyclic peptide sequences that greatly inhibited Aβ42 aggregation when cyclized in vitro and grafted as a loop sequence on proteinogenic scaffolds.
ByungUk Lee +3 more
wiley +1 more source
Protein Structure Determination by Racemic and Quasi‐Racemic X‐Ray Crystallography
ChemBioChem, Volume 27, Issue 4, 25 February 2026.Racemic mixtures of protein enantiomers facilitate formation of diffraction‐quality crystals in centrosymmetric space groups that have quantized phases which simplify structure solution. Quasi‐racemic mixtures of a protein and its mirror image isomorph similarly facilitate formation of highly ordered crystals.
Stephen B. H. Kent
wiley +1 more source
, 2015 Cyclotides are small disulfide-rich plant peptides. Their unique structural features, intrinsic bioactivities, and enormous sequence diversity make them interesting molecules for pharmaceutical applications.
Gruber, Christian W. +3 more
core +1 more source
Nematicidal Activity of Cyclotides: Toxicity Against Caenorhabditis elegans
, 2023 Cyclotides are a unique family of stable and cyclic mini-proteins found in plants that have nematicidal and anthelmintic activities. They are distributed across the Rubiaceae, Violaceae, Fabaceae, Cucurbitaceae, and Solanaceae plant families, where they ...
Yen-Hua Huang (409275) +15 more
core +1 more source
Plant Biotechnology Journal, Volume 24, Issue 1, Page 31-43, January 2026.Summary In plant molecular farming, recombinant products include traditional protein targets, such as antibodies, antigens, and enzymes, but also increasingly refers to high‐value peptides, and small molecules produced by heterologous enzymatic pathways.
Maxim D. Harding, Frank Sainsbury
wiley +1 more source
Bioinformatics and Biology Insights, 2020 Even before the perception or interaction with pathogens, plants rely on constitutively guardian molecules, often specific to tissue or stage, with further expression after contact with the pathogen.
Carlos André dos Santos-Silva +13 more
doaj +1 more source
Repositioning Antimicrobial Peptides Against WHO‐Priority Fungi
Advanced Science, Volume 12, Issue 37, October 6, 2025.The growing burden of drug‐resistant fungal infections, driven by pathogens such as Candida auris, Cryptococcus neoformans, and Aspergillus fumigatus, underscores the urgent need for novel antifungal therapies. This review explores antimicrobial peptides as promising agents with membrane‐disruptive activity, immunomodulatory properties, and delivery ...
Cesar Augusto Roque‐Borda +12 more
wiley +1 more source