Comparison of a Short Linear Antimicrobial Peptide with Its Disulfide-Cyclized and Cyclotide-Grafted Variants against Clinically Relevant Pathogens [PDF]
Microorganisms, 2021 According to the World Health Organization (WHO) the development of resistance against antibiotics by microbes is one of the most pressing health concerns.
Johannes Koehbach +2 more
exaly +4 more sources
Design of a MCoTI-Based Cyclotide with Angiotensin (1-7)-Like Activity
Molecules, 2016 We report for the first time the design and synthesis of a novel cyclotide able to activate the unique receptor of angiotensin (1-7) (AT1-7), the MAS1 receptor.
Subhabrata Majumder +2 more
exaly +4 more sources
Notes on the Treatment of Charged Particles for Studying Cyclotide/Membrane Interactions with Dissipative Particle Dynamics [PDF]
Membranes, 2022 Different charge treatment approaches are examined for cyclotide-induced plasma membrane disruption by lipid extraction studied with dissipative particle dynamics. A pure Coulomb approach with truncated forces tuned to avoid individual strong ion pairing
Felix Bänsch +2 more
exaly +4 more sources
Chemical Synthesis and Functional Analysis of VarvA Cyclotide
Molecules, 2018 Cyclotides are circular peptides found in various plant families. A cyclized backbone, together with multiple disulfide bonds, confers the peptides’ exceptional stability against protease digestion and thermal denaturation.
Claudio A Alvarez +2 more
exaly +4 more sources
A new “era” for cyclotide sequencing [PDF]
Biopolymers, 2010 In recent years, the discovery of a large family of macro cyclic peptides, the cyclotides, has revealed Nature's ingenuity in molecular drug design. The incorporation of a cyclic peptide backbone and a knotted arrangement of disulfide bridges into their ...
Michelle L Colgrave +2 more
exaly +6 more sources
Genome-wide in silico and in vitro mining to develop a novel cyclotide-based marker system in plants
Biotechnology & Biotechnological Equipment, 2023 Cyclotides are cysteine-rich cyclic peptides that have various activities and applications. Mining at the whole-genome scale facilitates the profiling and development of cyclotide-based markers. However, the characterization of cyclotide subfamilies at a
Arwa Salah +3 more
doaj +2 more sources
Using the Cyclotide Scaffold for Targeting Biomolecular Interactions in Drug Development
Molecules, 2022 This review provides an overview of the properties of cyclotides and their potential for developing novel peptide-based therapeutics. The selective disruption of protein–protein interactions remains challenging, as the interacting surfaces are relatively
Binu Jacob +3 more
doaj +2 more sources
Cyclotide host-defense tailored for species and environments in violets from the Canary Islands [PDF]
Scientific Reports, 2021 Cyclotides are cyclic peptides produced by plants. Due to their insecticidal properties, they are thought to be involved in host defense. Violets produce complex mixtures of cyclotides, that are characteristic for each species and variable in different ...
Blazej Slazak +8 more
doaj +2 more sources
BMC Genomics, 2010 Background Cyclotides are a family of circular peptides that exhibit a range of biological activities, including anti-bacterial, cytotoxic, anti-HIV activities, and are proposed to function in plant defence.
Suda Jan +6 more
doaj +2 more sources
Frontiers in Molecular Biosciences, 2022 Aggregation of β-amyloid (Aβ) peptide is one of the hallmarks of Alzheimer’s disease (AD) which results in chronic and progressive neurodegeneration of the brain.
Neha V. Kalmankar +4 more
doaj +2 more sources