Results 11 to 20 of about 578 (154)
Journal of Evidence-Based Complementary & Alternative Medicine, 2012 In recent years, a number of peptides containing a cyclic structural fold have been described. Among them, the cyclotides family was widely reported in different plant tissues, being composed of small cyclic peptides containing 6 conserved cysteine ...
Michelle F. S. Pinto +6 more
doaj +3 more sources
Host-Defense Activities of Cyclotides [PDF]
Toxins, 2012 Cyclotides are plant mini-proteins whose natural function is thought to be to protect plants from pest or pathogens, particularly insect pests. They are approximately 30 amino acids in size and are characterized by a cyclic peptide backbone and a cystine
David J. Craik
doaj +6 more sources
Cyclotide isolation and characterization
, 2012 Cyclotides are disulfide-rich cyclic peptides produced by plants with the presumed natural function of defense agents against insect pests. They are present in a wide range of plant tissues, being ribosomally synthesized via precursor proteins that are ...
David J. Craik +7 more
core +6 more sources
T20K: An Immunomodulatory Cyclotide on Its Way to the Clinic
International Journal of Peptide Research and Therapeutics, 2018 Cyclotides represent a new class of natural plant compounds, which could be considered ideal “template” molecules for drug design. Their structure is characterized by a circular cystine-knot motif, comprising an amino acid chain stabilized by three ...
Carsten Gründemann +2 more
exaly +2 more sources
Cyclotide interactions with the nematode external surface [PDF]
Antimicrobial Agents and Chemotherapy, 2010 Cyclotides are a large family of cyclic cystine knot-containing plant peptides that have anthelminthic activities against Haemonchus contortus and Trichostrongylus colubriformis, two important gastrointestinal nematodes of sheep.
Colgrave, Michelle L. +7 more
core +7 more sources
Biosynthesis of a Fully Functional Cyclotide inside Living Bacterial Cells [PDF]
ChemBioChem, 2007 The cyclotide MCoTI-II is a powerful trypsin inhibitor recently isolated from the seeds of Momordica cochinchinensis, a plant member of cucurbitaceae family. We report for the first time the in vivo biosynthesis of natively-folded MCoTI-II inside live E.
Julio A Camarero, Alexander Shekhtman
exaly +1 more source
A Cyclotide Isolated from Noisettia orchidiflora (Violaceae)
Planta Medica, 2018 Biologically active cyclotides have been found on some flowering plants species and are involved in the role of the plant protection. As part of studies focusing on peptides from Brazilian plant species, we are reporting the detection by LC-MS of several
Meri Emili F Pinto +2 more
exaly +3 more sources
Applied Microbiology and Biotechnology, 2007 Cyclotides, a family of disulfide-rich mini-proteins, show a wide range of biological activities, making them interesting targets for pharmaceutical and agrochemical applications, but little is known about their natural function and the events that ...
Dörnenburg, H. +3 more
core +6 more sources
Discovery of the cyclotide caripe 11 as a ligand of the cholecystokinin-2 receptor
Scientific Reports, 2022 The cholecystokinin-2 receptor (CCK2R) is a G protein-coupled receptor (GPCR) that is expressed in peripheral tissues and the central nervous system and constitutes a promising target for drug development in several diseases, such as gastrointestinal ...
Mohammad Sadegh Taghizadeh +8 more
doaj +1 more source
, 2021 Cyclotide-induced membrane disruption is studied at the microsecond timescale by Dissipative Particle Dynamics (DPD) to quantitatively estimate a kinetic rate constant for membrane lipid extraction with a “sandwich” interaction model where two bilayer ...
Karina, van den Broek +4 more
core +1 more source