Results 41 to 50 of about 578 (154)
Computational Design of Hypothetical New Peptides Based on a Cyclotide Scaffold as HIV gp120 Inhibitor. [PDF]
PLoS ONE, 2015 Cyclotides are a family of triple disulfide cyclic peptides with exceptional resistance to thermal/chemical denaturation and enzymatic degradation. Several cyclotides have been shown to possess anti-HIV activity, including kalata B1 (KB1).
Apiwat Sangphukieo +4 more
doaj +1 more source
Induction and destruction of folding motifs in cyclotides by cyclic cystine knots
Chemical Physics Impact, 2023 Multivariate roles of cyclic cystine knots (CCK) present in cyclotides are well known. More than often this marvellous combination of disulphide linkages embedded in a macrocyclic backbone is seen to induce and stabilize otherwise unfavourable secondary ...
Jayapriya Venkatesan, Durba Roy
doaj +1 more source
, 2010 Cyclotides are disulfide-rich plant proteins that are exceptional in their cyclic Structure; their N and C termini are joined by a peptide bond, forming a continuous circular backbone, which is reinforced by three interlocked disulfide bonds.
Gruber, Christian W. +6 more
core +1 more source
An Ultrapotent and Selective Cyclic Peptide Inhibitor of Human Factor XIIa in a Cyclotide Scaffold
, 2021 Cyclotides are plant-derived peptides with complex structures shaped by their head-to-tail cyclic backbone and cystine knot core. These structural features underpin the native bioactivities of cyclotides, as well as their beneficial properties as ...
Yen-Hua Huang (409275) +23 more
core +1 more source
Cyclotides: Overview and Biotechnological Applications [PDF]
ChemBioChem, 2017 AbstractCyclotides are globular microproteins with a unique head‐to‐tail cyclized backbone, stabilized by three disulfide bonds forming a cystine knot. This unique circular backbone topology and knotted arrangement of three disulfide bonds makes them exceptionally stable to chemical, thermal, and biological degradation compared to other peptides of ...
Andrew Gould, Julio A. Camarero
openaire +2 more sources
, 2009 Cyclotides are a novel family of plant-derived defense peptides that are biosynthetically produced via the processing of cyclotide precursor (CP) proteins containing one, two or three cyclotide domains.
Hu, M +5 more
core +1 more source
Exogenous plant hormones and cyclotide expression in Viola uliginosa (Violaceae)
, 2015 Plants from Violaceae produce cyclotides, peptides characterized by a circular peptide backbone and a cystine knot. This signature motif gives stability that can harness a wide spectrum of biological activities, with implications in plant defense and ...
Jacobsson, Erik, +7 more
core +1 more source
ChemBioChem, Volume 27, Issue 8, April 2026.Split intein mediated circular ligation of peptide and proteins mediated selection of 7‐mer cyclic peptide library for binding Amyloid‐β oligomers identified cyclic peptide sequences that greatly inhibited Aβ42 aggregation when cyclized in vitro and grafted as a loop sequence on proteinogenic scaffolds.
ByungUk Lee +3 more
wiley +1 more source
Genome-wide in silico and in vitro mining to develop a novel cyclotide-based marker system in plants
, 2023 Cyclotides are cysteine-rich cyclic peptides that have various activities and applications. Mining at the whole-genome scale facilitates the profiling and development of cyclotide-based markers. However, the characterization of cyclotide subfamilies at a
Reda Mohamed Gaafar (14663215) +3 more
core +1 more source
Protein Structure Determination by Racemic and Quasi‐Racemic X‐Ray Crystallography
ChemBioChem, Volume 27, Issue 4, 25 February 2026.Racemic mixtures of protein enantiomers facilitate formation of diffraction‐quality crystals in centrosymmetric space groups that have quantized phases which simplify structure solution. Quasi‐racemic mixtures of a protein and its mirror image isomorph similarly facilitate formation of highly ordered crystals.
Stephen B. H. Kent
wiley +1 more source