Results 51 to 60 of about 578 (154)
Engineered biosynthesis of cyclotides [PDF]
New Zealand Journal of Botany, 2020 A system based on cyanobacterial split inteins, SICLOPPs (Split Intein Circular Ligation of Proteins and Peptides), has been used to synthesise a small natively cyclic plant protein, kalata B1, and cyclised versions of the natively linear therapeutic peptides ziconotide and leconotide.
Thomas N. G. Handley +8 more
openaire +4 more sources
Molecular Dynamics Simulations Cyclotide Kalata B1 Interactions with Lipid Bilayers
MoleculesCyclotides are exceptionally stable plant peptides whose biological activity is widely attributed to interactions with lipid membranes, yet the molecular mechanisms underlying these interactions remain incompletely resolved.
Neville Y. Forlemu +4 more
doaj +1 more source
Plant Biotechnology Journal, Volume 24, Issue 1, Page 31-43, January 2026.Summary In plant molecular farming, recombinant products include traditional protein targets, such as antibodies, antigens, and enzymes, but also increasingly refers to high‐value peptides, and small molecules produced by heterologous enzymatic pathways.
Maxim D. Harding, Frank Sainsbury
wiley +1 more source
Schematic illustration of cyclotide structure.
, 2014 A 3D illustration of the cyclotide structure showing the CCK motif (with cysteines labeled I–IV), and the inter-cysteine loops (labeled 1–6). The CCK motif is characterized by a cyclic peptide backbone and the knotted disulfide bonds (I–IV, II–V, III–VI),
Sungkyu Park (544757) +2 more
core +1 more source
Cyclotides as novel plant-derived scaffolds for orally active cyclic peptide therapeutics
Molecules and Cells: Cyclotides are a group of plant-derived small peptides, characterized by a head-to-tail cyclic backbone and 3 conserved cysteine knots. The unique structure endows cyclotides with exceptional chemical stability and intrinsic cell-penetrating capacities,
Youbong Hyun
doaj +1 more source
Frontiers in Plant Science, 2019 Viola is a large genus with worldwide distribution and many traits not currently exemplified in model plants including unique breeding systems and the production of cyclotides. Here we report de novo genome assembly and transcriptomic analyses of the non-
Anne L. Sternberger +7 more
doaj +1 more source
Repositioning Antimicrobial Peptides Against WHO‐Priority Fungi
Advanced Science, Volume 12, Issue 37, October 6, 2025.The growing burden of drug‐resistant fungal infections, driven by pathogens such as Candida auris, Cryptococcus neoformans, and Aspergillus fumigatus, underscores the urgent need for novel antifungal therapies. This review explores antimicrobial peptides as promising agents with membrane‐disruptive activity, immunomodulatory properties, and delivery ...
Cesar Augusto Roque‐Borda +12 more
wiley +1 more source
The Potential of the Cyclotide Scaffold for Drug Development
Biomedicines, 2019 Cyclotides are a novel class of micro-proteins (≈30–40 residues long) with a unique topology containing a head-to-tail cyclized backbone structure further stabilized by three disulfide bonds that form a cystine knot.
Julio A. Camarero, Maria Jose Campbell
doaj +1 more source
Proposed EU NGT legislation in light of plant genetic variation
Plant Biotechnology Journal, Volume 23, Issue 10, Page 4261-4270, October 2025.Summary The European Commission (EC) proposal for New Genomic Techniques (NGTs) of July 2023 specifies that Category 1 NGT (NGT1) plants, which are considered equivalent to conventional plants, that is those obtainable by conventional plant breeding or mutagenesis, may differ from the recipient or parental plant by no more than 20 insertions, which ...
Alan H. Schulman +6 more
wiley +1 more source
, 2016 Herein, we report for the first time the design and synthesis of a novel cyclotide able to efficiently inhibit HIV-1 viral replication by selectively targeting cytokine receptor CXCR4.
Helen Ha (1545223) +7 more
core +1 more source