Results 31 to 40 of about 578 (154)

RaPID Selection of Backbone Macrocyclic Peptides Targeting Akt2

Angewandte Chemie, Volume 138, Issue 21, 18 May 2026.
Backbone macrocyclic peptide library (BMP) library was screened against Akt2 via RaPID to discover potent BMPPakti‐3 (IC50 = 34 nM). ABSTRACT Backbone‐cyclic peptides (BMPs) are an attractive class of molecules appeared in diverse natural bioactive products. However, mRNA display technology coupled with ribosomal synthesis is intrinsically inapplicable
Koki Shinbara, Ekishin Yanagi, Ayaka Aizawa, Takayuki Katoh, Hiroaki Suga   +4 more
wiley   +2 more sources

Repurposing the McoTI-II Rigid Molecular Scaffold in to Inhibitor of ‘Papain Superfamily’ Cysteine Proteases

Pharmaceuticals, 2020
Clan C1A or ‘papain superfamily’ cysteine proteases are key players in many important physiological processes and diseases in most living systems. Novel approaches towards the development of their inhibitors can open new avenues in translational medicine.
Manasi Mishra, Vigyasa Singh, Meenakshi B. Tellis, Rakesh S. Joshi, Shailja Singh   +4 more
doaj   +1 more source

Cyclotides as drug design scaffolds [PDF]

Current Opinion in Chemical Biology, 2017
Cyclotides are ultra-stable peptides derived from plants. They are around 30 amino acids in size and are characterized by their head-to-tail cyclic backbone and cystine knot. Their exceptional stability and tolerance to sequence substitutions has led to their use as frameworks in drug design.
Craik, David J., Du, Junqiao
openaire   +4 more sources

Chemical Synthesis, Backbone Cyclization and Oxidative Folding of Cystine-knot Peptides — Promising Scaffolds for Applications in Drug Design

Molecules, 2012
Cystine-knot peptides display exceptional structural, thermal, and biological stability. Their eponymous motif consists of six cysteine residues that form three disulfide bonds, resulting in a notably rigid structural core.
Olga Avrutina, Michael Reinwarth, Harald Kolmar, Daichi Nasu   +3 more
doaj   +1 more source

Inhibition of human prolyl oligopeptidase activity by the Cyclotide Psysol 2 isolated from Psychotria solitudinum [PDF]

, 2020
Cyclotides are head-to-tail cyclized peptides comprising a stabilizing cystine-knot motif. To date, they are well known for their diverse bioactivities such as anti-HIV and immunosuppressive properties.
Clark, Richard J., Giralt Lledó, Ernest, Gruber, Christian W., Hellinger, Roland, Koehbach, Johannes, Tarragó Clua, Maria Teresa, Puigpinós, Albert   +6 more
core   +2 more sources

Scorpion Toxins Specific for Potassium (K+) Channels: A Historical Overview of Peptide Bioengineering

Toxins, 2012
Scorpion toxins have been central to the investigation and understanding of the physiological role of potassium (K+) channels and their expansive function in membrane biophysics.
Zachary L. Bergeron, Jon-Paul Bingham
doaj   +1 more source

Dynamic scenario of membrane binding process of kalata b1. [PDF]

PLoS ONE, 2014
Kalata B1 (kB1), a cyclotide that has been used in medical applications, displays cytotoxicity related to membrane binding and oligomerization. Our molecular dynamics simulation results demonstrate that Trp19 in loop 5 of both monomeric and tetrameric ...
Wanapinun Nawae, Supa Hannongbua, Marasri Ruengjitchatchawalya   +2 more
doaj   +1 more source

Cycloviolacin H4, a hydrophobic cyclotide from Viola hederaceae

, 2006
Cycloviolacin H4, a new macrocyclic miniprotein comprising 30 amino acid residues, was isolated from the underground parts of the Australian native violet Viola hederaceae. Its sequence, cyclo-(CAESCVWIPCTVTALLGCSCSNNVCYNGIP), was determined by nanospray
Michelle L. Colgrave, Colurave, ML, Craik, D. J., Colgrave, M. L., Craik, DJ, Univ Queensland, Australian Res Council, Special Res Ctr Funct & Appl Genom, Inst Mol Biosci, Brisbane, Qld 4072, Australia., Bin Chen, Wang, CN, David J. Craik, Conan Wang, Chen, B, Chen, B., Wang, C. N., Craik, DJ   +12 more
core   +1 more source

Comprehensive Mapping of Cyclotides from Viola philippica by Using Mass Spectrometry-Based Strategy

Molecules
Cyclotides are plant cyclic peptides with exceptional stability and diverse bioactivity, making them promising candidates for biomedical applications. Therefore, the study of cyclotides has attracted increasing attention in recent years.
Liyan Yu, Hailiang Pan, Xiaohang Chen, Shan Gong, Qipeng Zhang, Yandong Zhang, Zhajun Zhan   +6 more
doaj   +1 more source

A bifunctional asparaginyl endopeptidase efficiently catalyzes both cleavage and cyclization of cyclic trypsin inhibitors

Nature Communications, 2020
Asparaginyl endopeptidases (AEPs) catalyze the cyclization step during the biosynthesis of cyclic peptides in plants. Here, the authors report a recombinantly produced AEP that catalyzes the backbone cyclization of a linear cyclotide precursor and an ...
Junqiao Du, Kuok Yap, Lai Yue Chan, Fabian B. H. Rehm, Fong Yang Looi, Aaron G. Poth, Edward K. Gilding, Quentin Kaas, Thomas Durek, David J. Craik   +9 more
doaj   +1 more source