Results 71 to 80 of about 1,205 (188)
Cyclotides Chemosensitize Glioblastoma Cells to Temozolomide
, 2022 Glioblastoma multiforme (GBM) is the most aggressive cancer originating in the brain, with a median survival of 12 months. Most patients do not respond to or develop resistance to the only effective chemotherapeutic drug, temozolomide (TMZ), used to ...
Paul Alan Cox (8956049) +9 more
core +1 more source
Navigating a 1E+60 Chemical Space of Peptide/Peptoid Oligomers
Molecular Informatics, Volume 44, Issue 1, January 2025.Herein we report a virtual library of 1E+60 members, a common estimate for the size of the drug‐like chemical space. The library consists of linear or cyclic oligomers forming molecules within the size range of peptide drugs. We demonstrate ligand‐based virtual screening using a genetic algorithm.
Markus Orsi, Jean‐Louis Reymond
wiley +1 more source
Chemical Synthesis and Functional Analysis of VarvA Cyclotide
Molecules, 2018 Cyclotides are circular peptides found in various plant families. A cyclized backbone, together with multiple disulfide bonds, confers the peptides’ exceptional stability against protease digestion and thermal denaturation.
Claudio A. Álvarez +6 more
doaj +1 more source
Topical Delivery Systems for Plant‐Derived Antimicrobial Agents: A Review of Current Advances
International Journal of Biomaterials, Volume 2025, Issue 1, 2025.Plant‐derived compounds have attracted considerable attention in the field of antimicrobial therapy. This interest is primarily due to their natural origin and historical evidence of their use in traditional medicine systems. These derivatives are a rich reservoir of chemical diversity that has a promising potential for the development and production ...
Mohammad Hashem Hashempur +10 more
wiley +1 more source
Exogenous plant hormones and cyclotide expression in Viola uliginosa (Violaceae)
Phytochemistry, 2015 Plants from Violaceae produce cyclotides, peptides characterized by a circular peptide backbone and a cystine knot. This signature motif gives stability that can harness a wide spectrum of biological activities, with implications in plant defense and with applications in medicine and biotechnology.
Slazak, Blazej +4 more
openaire +3 more sources
Frontiers in Plant Science, 2019 The perennial leguminous herb Clitoria ternatea (butterfly pea) has attracted significant interest based on its agricultural and medical applications, which range from use as a fodder and nitrogen fixing crop, to applications in food coloring and ...
Georgianna K. Oguis +3 more
doaj +1 more source
Display Technologies for Expanding the Pharmaceutical Applications of Cyclotides
Israel Journal of Chemistry, Volume 64, Issue 8-9, September 2024.Abstract Cyclotides are ultra‐stable peptides originally discovered in plants based on their medicinal applications. Their natural function is as host defence agents. They are amenable to chemical synthesis for use as scaffolds for drug design applications.
Jing Xie +4 more
wiley +1 more source
Protein Grafting Techniques: From Peptide Epitopes to Lasso‐Grafted Neobiologics
ChemPlusChem, Volume 89, Issue 8, August 2024.The idea of grafting small peptide pharmacophores onto larger protein scaffolds, thus harvesting the advantages of both, has given rise to a variety of protein engineering strategies that are reviewed herein. We also describe our own “Lasso‐Grafting” approach, which combines traditional grafting concepts with mRNA display to streamline the production ...
Mikio Imai, Kilian Colas, Hiroaki Suga
wiley +1 more source
Design and therapeutic applications of cyclotides
, 2009 Cyclotides are plant-derived peptides with a cyclic backbone and knotted topology of disulfide bonds. Their extreme stability and natural sequence variation has led to the suggestion that they might be useful as scaffolds to stabilize bioactive sequences.
Daly, Norelle L., Craik, David J.
core +1 more source
Strategies of plants to overcome abiotic and biotic stresses
Biological Reviews, Volume 99, Issue 4, Page 1524-1536, August 2024.ABSTRACT In their environment, plants are exposed to a multitude of abiotic and biotic stresses that differ in intensity, duration and severity. As sessile organisms, they cannot escape these stresses, but instead have developed strategies to overcome them or to compensate for the consequences of stress exposure.
Baoguo Du +3 more
wiley +1 more source