Results 81 to 90 of about 1,205 (188)
A Continent of Plant Defense Peptide Diversity: Cyclotides in AustralianHybanthus(Violaceae) [PDF]
The Plant Cell, 2005 AbstractCyclotides are plant-derived miniproteins that have the unusual features of a head-to-tail cyclized peptide backbone and a knotted arrangement of disulfide bonds. It had been postulated that they might be an especially large family of host defense agents, but this had not yet been tested by field data on cyclotide variation in wild plant ...
Simonsen, S. M. +6 more
openaire +5 more sources
Plant thionins: structure, biological functions and potential use in biotechnology
Вавиловский журнал генетики и селекции, 2018 Antimicrobial peptides (AMPs) are important components of defense system in both plants and animals. They represent an ancient mechanism of innate immunity providing rapid first line of defense against pathogens.
T. I. Odintsova +2 more
doaj +1 more source
Molecular farming for sustainable production of clinical‐grade antimicrobial peptides
Plant Biotechnology Journal, Volume 22, Issue 8, Page 2282-2300, August 2024.Summary Antimicrobial peptides (AMPs) are emerging as next‐generation therapeutics due to their broad‐spectrum activity against drug‐resistant bacterial strains and their ability to eradicate biofilms, modulate immune responses, exert anti‐inflammatory effects and improve disease management. They are produced through solid‐phase peptide synthesis or in
Shahid Chaudhary +2 more
wiley +1 more source
Structure and Activity of Reconstructed Pseudo‐Ancestral Cyclotides
ChemMedChem, Volume 19, Issue 14, July 15, 2024.Ancestral sequence reconstruction was used to predict two ancestral cyclotides, Ancy‐m and Ancy‐b. These two predicted ancestors maintained their stability and activities. Meanwhile, Ancy‐b had an improved folding yield over the prototypical bracelet cyclotide.
Zhihao Jiang +4 more
wiley +1 more source
ChemBioChem, Volume 25, Issue 3, February 1, 2024.The biosynthetic pathway for the peptide natural product omphalotin A of the agaricomycete Omphalotus olearius can be exploited for the production of non‐natural, multiply backbone N‐methylated peptide macrocycles in the yeast Pichia pastoris (Komagataella phaffii).
Emmanuel Matabaro +5 more
wiley +1 more source
Characterizing circular peptides in mixtures: sequence fragment assembly of cyclotides from a violet plant by MALDI-TOF/TOF mass spectrometry [PDF]
, 2012 Cyclotides are a very abundant class of plant peptides that display significant sequence variability around a conserved cystine-knot motif and a head-to-tail cyclized backbone conferring them with remarkable stability.
Alireza Ghassempour +13 more
core +1 more source
Letters in Animal BiologyAntimicrobial peptides (AMPs) are a class of short, usually positively charged, polypeptides which are widely used to overcome the threat of the antimicrobial resistance. The potential of the AMPs is increasing as a new class of antibiotics.
Asif Ali +10 more
doaj +1 more source
Cyclotides as natural anti-HIV agents
, 2008 Cyclotides are disulfide rich macrocyclic plant peptides that are defined by their unique topology in which a head-to-tail cyclized backbone is knotted by the interlocking arrangement of three disulfide bonds.
Ireland, David C. +9 more
core +1 more source
Cyclic Peptides for Drug Development
Angewandte Chemie, Volume 136, Issue 3, January 15, 2024.Cyclic peptides combine a number of favorable properties that make them attractive for drug development. Today, more than 40 therapeutics based on cyclic peptides are in use, and new, powerful technologies for their development suggest that this number could grow rapidly.
Xinjian Ji +2 more
wiley +1 more source
Pharmaceutical applications of cyclotides
, 2019 Cyclotides are cyclic peptides, present in several plant families, that show diverse biological properties. Structurally, cyclotides share a distinctive head-to-tail circular knotted topology of three disulfide bonds.
Franco, Octávio L. +2 more
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