Results 11 to 20 of about 1,205 (188)

The life cycle of cyclotides : biosynthesis and turnover in plant cells [PDF]

Plant Cell Reports, 2020
Key message Turnover rates have implications for understanding cyclotide biology and improving plant cell culture-based production systems. Cyclotides are a family of polypeptides recognized for a broad spectrum of bioactivities. The cyclic, cystine knot
Haugmo, Tobias,, Göransson, Ulf,, Badyra, Bogna, Slazak, Blazej,, Göransson, Ulf, Badyra, Bogna,, Slazak, Blazej, Haugmo, Tobias   +7 more
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Discovery and applications of the plant cyclotides

Toxicon, 2010
The cyclotides are a family of plant-derived proteins that occur in plants from the Violaceae (violet), Rubiaceae (coffee) and Cucurbitaceae (cucurbit) families and have a diverse range of biological activities, including uterotonic, anti-HIV ...
Craik, David J.
core   +8 more sources

Screening for Cyclotides in Sri Lankan Medicinal Plants: Discovery, Characterization, and Bioactivity Screening of Cyclotides from Geophila repens

Journal of Natural Products, 2022
[Image: see text] Cyclotides are an intriguing class of structurally stable circular miniproteins of plant origin with numerous potential pharmaceutical and agricultural applications.
Kapusta, Małgorzata, Chamari M. Hettiarachchi, Rajendran, Sanjeevan,, Supun Mohotti, Emilia Wilmowicz, Gunasekera, Sunithi,, Sunithi Gunasekera, Strömstedt, Adam A.,, Kapusta, Malgorzata, Sanjeevan Rajendran, Blazej Slazak, Göransson, Ulf,, Muhammad, Taj,, Kapusta, Malgorzata,, Wilmowicz, Emilia,, Adam A. Strömstedt, Taj Muhammad, Mohotti, Supun,, Rajendran, Sanjeevan, Mohotti, Supun, Slazak, Blazej,, Göransson, Ulf, Strömstedt, Adam A., Hettiarachchi, Chamari M., Wilmowicz, Emilia, Ulf Göransson, Muhammad, Taj, Gunasekera, Sunithi, Hettiarachchi, Chamari M.,, Slazak, Blazej, Małgorzata Kapusta   +30 more
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Kalata B1 Enhances Temozolomide Toxicity to Glioblastoma Cells [PDF]

Biomedicines
Glioblastoma (GBM) is the most aggressive cancer originating in the brain, but unfortunately combination treatments with resection, radiation, and chemotherapy are relatively ineffective. Therefore, novel methods of adjuvant therapy are critically needed.
Samantha L. Gerlach, James S. Metcalf, Rachael A. Dunlop, Sandra Anne Banack, Cheenou Her, Viswanathan V. Krishnan, Ulf Göransson, Sunithi Gunasekera, Blazej Slazak, Paul Alan Cox   +9 more
doaj   +2 more sources

Peptides from plants and microorganisms: a defense strategy for biotic and abiotic stresses [PDF]

Frontiers in Plant Science
Antimicrobial peptides (AMPs) from plants and microorganisms have emerged as promising tools due to their multifunctional roles in plant defense. These small, bioactive molecules, such as thionins, systemins, defensins, cyclotides, hevein-like peptides ...
Dung Minh Ha-Tran, Dung Minh Ha-Tran, Chieh-Chen Huang, Chieh-Chen Huang, Chieh-Chen Huang   +4 more
doaj   +2 more sources

Molecular Dynamics Simulations Cyclotide Kalata B1 Interactions with Lipid Bilayers [PDF]

Molecules
Cyclotides are exceptionally stable plant peptides whose biological activity is widely attributed to interactions with lipid membranes, yet the molecular mechanisms underlying these interactions remain incompletely resolved.
Neville Y. Forlemu, Eric N. Njabon, Ajay Mallia, Simon Mwongela, Sairam Tangirala   +4 more
doaj   +2 more sources

15N cyclotides by whole plant labeling

Peptide Science, 2008
Cyclotides are 28-37 amino acid peptides incorporating three disulfide bonds and a cyclic backbone. Their cyclic and knotted topology renders them immune to denaturation by heat or organic solvents and highly resistant to proteolysis.
Mylne, Joshua S., Craik, David J.
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Discovery of cyclotides from Australasian plants [PDF]

Australian Journal of Chemistry, 2020
This article is part of a special issue celebrating the contributions of Professor Paul Alewood to peptide science. We begin by providing a summary of collaborative projects between the Alewood and Craik groups at The University of Queensland and ...
Kan, Meng-Wei, Craik, David J.
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Plant Antimicrobial Peptides and Their Main Families and Roles: A Review of the Literature [PDF]

Current Issues in Molecular Biology
Antimicrobial peptides (AMPs) are constituent molecules of the innate defense system and are naturally produced by all organisms. AMPs are characterized by a relatively low molecular weight (less than 10 kDa) and a variable number of cysteine residues ...
Samuel Salomão Silva de Oliveira, Milena Bellei Cherene, Gabriel Bonan Taveira, Érica de Oliveira Mello, André de Oliveira Carvalho, Valdirene Moreira Gomes   +5 more
doaj   +2 more sources

Antimicrobial peptides: emerging next-generation strategy for sustainable plant disease management [PDF]

Frontiers in Antibiotics
Plant diseases reduce agricultural productivity worldwide, and this decline is further accelerated by climate variability, monoculture cultivation systems, and the excessive use of synthetic agrochemicals.
Dipayan Das, Tasqeen Khan, Jinkee Kalita, Sarvesh Rustagi, Sujogya Kumar Panda, Niraj Singh, Yugal Kishore Mohanta   +6 more
doaj   +2 more sources