Results 41 to 50 of about 1,652 (193)
A new “era” for cyclotide sequencing [PDF]
Peptide Science, 2010 AbstractIn recent years, the discovery of a large family of macrocyclic peptides, the cyclotides, has revealed Nature's ingenuity in molecular drug design. The incorporation of a cyclic peptide backbone and a knotted arrangement of disulfide bridges into their structures confers extraordinary chemical, thermal, and enzymatic stability on these ...
Colgrave, Michelle L. +3 more
openaire +4 more sources
Cyclotide host-defense tailored for species and environments in violets from the Canary Islands
Scientific Reports, 2021 Cyclotides are cyclic peptides produced by plants. Due to their insecticidal properties, they are thought to be involved in host defense. Violets produce complex mixtures of cyclotides, that are characteristic for each species and variable in different ...
Blazej Slazak +8 more
doaj +1 more source
PLoS ONE, 2014 Cyclotides are a family of plant-derived proteins that are characterized by a cyclic backbone and a knotted disulfide topology. Their cyclic cystine knot (CCK) motif makes them exceptionally resistant to thermal, chemical, and enzymatic degradation ...
Sungkyu Park +2 more
doaj +1 more source
Enabling Efficient Folding and High-Resolution Crystallographic Analysis of Bracelet Cyclotides
Molecules, 2021 Cyclotides have attracted great interest as drug design scaffolds because of their unique cyclic cystine knotted topology. They are classified into three subfamilies, among which the bracelet subfamily represents the majority and comprises the most ...
Yen-Hua Huang +6 more
doaj +1 more source
Frontiers in Molecular Biosciences, 2022 Aggregation of β-amyloid (Aβ) peptide is one of the hallmarks of Alzheimer’s disease (AD) which results in chronic and progressive neurodegeneration of the brain.
Neha V. Kalmankar +4 more
doaj +1 more source
The involvement of cyclotides in mutual interactions of violets and the two-spotted spider mite
Scientific Reports, 2022 Plants employ different chemicals to protect themselves from herbivory. These defenses may be constitutive or triggered by stress. The chemicals can be toxic, act as repellents, phagosuppressants and/or phago-deterrents.
Blazej Slazak +11 more
doaj +1 more source
Cyclotides Chemosensitize Glioblastoma Cells to Temozolomide
, 2022 Glioblastoma multiforme (GBM) is the most aggressive cancer originating in the brain, with a median survival of 12 months. Most patients do not respond to or develop resistance to the only effective chemotherapeutic drug, temozolomide (TMZ), used to ...
Paul Alan Cox (8956049) +9 more
core +1 more source
Cyclotides: From Structure to Function [PDF]
Chemical Reviews, 2019 This Review explores the class of plant-derived macrocyclic peptides called cyclotides. We include an account of their discovery, characterization, and distribution in the plant kingdom as well as a detailed analysis of their sequences and structures, biosynthesis and chemical synthesis, biological functions, and applications.
Simon J. de Veer +2 more
openaire +5 more sources
Molecular Peptide Grafting as a Tool to Create Novel Protein Therapeutics
Molecules, 2023 The study of peptides (synthetic or corresponding to discrete regions of proteins) has facilitated the understanding of protein structure–activity relationships. Short peptides can also be used as powerful therapeutic agents.
Anton A. Komar
doaj +1 more source
RaPID Selection of Backbone Macrocyclic Peptides Targeting Akt2
Angewandte Chemie, Volume 138, Issue 21, 18 May 2026.Backbone macrocyclic peptide library (BMP) library was screened against Akt2 via RaPID to discover potent BMPPakti‐3 (IC50 = 34 nM). ABSTRACT Backbone‐cyclic peptides (BMPs) are an attractive class of molecules appeared in diverse natural bioactive products. However, mRNA display technology coupled with ribosomal synthesis is intrinsically inapplicable
Koki Shinbara +4 more
wiley +2 more sources