Results 51 to 60 of about 1,652 (193)
Frontiers in Plant Science, 2017 Cyclotides are a family of plant proteins that are characterized by a cyclic backbone and a knotted disulfide topology. Their cyclic cystine knot (CCK) motif makes them exceptionally resistant to thermal, chemical, and enzymatic degradation.
Sungkyu Park +7 more
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Frontiers in Pharmacology, 2017 Cyclotides are plant derived, cystine-knot stabilized peptides characterized by their natural abundance, sequence variability and structural plasticity. They are abundantly expressed in Rubiaceae, Psychotrieae in particular.
Mohsen Fahradpour +8 more
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Discovery of insecticidal cyclotides from the African plants Allexis batangae and Allexis obanensis
Industrial Crops and ProductsCyclotides are plant-derived cyclic peptides recognized for their crucial role in host defense against insects and fungal pathogens. They are characterized by an ultra-stable head-to-tail cyclic backbone and a cystine knot formed by three conserved ...
Negin Khatibi +7 more
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The Potential of the Cyclotide Scaffold for Drug Development
Biomedicines, 2019 Cyclotides are a novel class of micro-proteins (≈30–40 residues long) with a unique topology containing a head-to-tail cyclized backbone structure further stabilized by three disulfide bonds that form a cystine knot.
Julio A. Camarero, Maria Jose Campbell
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Harnessing cyclotides to design and develop novel peptide GPCR ligands
, 2020 Cyclotides are plant-derived cyclic, disulfide-rich peptides with a unique cyclic cystine knot topology that confers them with remarkable structural stability and resistance to proteolytic degradation.
Muratspahić, Edin +3 more
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Cyclotides Isolated From Violet Plants of Cameroon Are Inhibitors of Human Prolyl Oligopeptidase
Frontiers in Pharmacology, 2021 Traditional medicine and the use of herbal remedies are well established in the African health care system. For instance, Violaceae plants are used for antimicrobial or anti-inflammatory applications in folk medicine.
Jasmin Gattringer +5 more
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Induction and destruction of folding motifs in cyclotides by cyclic cystine knots
Chemical Physics Impact, 2023 Multivariate roles of cyclic cystine knots (CCK) present in cyclotides are well known. More than often this marvellous combination of disulphide linkages embedded in a macrocyclic backbone is seen to induce and stabilize otherwise unfavourable secondary ...
Jayapriya Venkatesan, Durba Roy
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Frontiers in Cellular and Infection Microbiology, 2020 Despite the continuous emergence of multi-drug resistant pathogens, the number of new antimicrobials reaching the market is critically low. Natural product peptides are a rich source of bioactive compounds, and advances in mass spectrometry have achieved
Nicole C. Parsley +2 more
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ChemBioChem, Volume 27, Issue 8, April 2026.Split intein mediated circular ligation of peptide and proteins mediated selection of 7‐mer cyclic peptide library for binding Amyloid‐β oligomers identified cyclic peptide sequences that greatly inhibited Aβ42 aggregation when cyclized in vitro and grafted as a loop sequence on proteinogenic scaffolds.
ByungUk Lee +3 more
wiley +1 more source
Nematicidal Activity of Cyclotides: Toxicity Against Caenorhabditis elegans
, 2023 Cyclotides are a unique family of stable and cyclic mini-proteins found in plants that have nematicidal and anthelmintic activities. They are distributed across the Rubiaceae, Violaceae, Fabaceae, Cucurbitaceae, and Solanaceae plant families, where they ...
Yen-Hua Huang (409275) +15 more
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