Results 71 to 80 of about 1,652 (193)
Frontiers in Plant Science, 2019 Viola is a large genus with worldwide distribution and many traits not currently exemplified in model plants including unique breeding systems and the production of cyclotides. Here we report de novo genome assembly and transcriptomic analyses of the non-
Anne L. Sternberger +7 more
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Decoding small peptides: Regulators of plant growth and stress resilience
Journal of Integrative Plant Biology, Volume 67, Issue 3, Page 596-631, March 2025.This review explores how small peptides act as key regulators of plant growth, development, and stress responses. It highlights recent advances in small peptide identification and their roles in enhancing plant resilience to environmental challenges, offering new perspectives for improving crop productivity.
Fei Xiao, Huapeng Zhou, Honghui Lin
wiley +1 more source
Native Chemical Ligation: A Boon to Peptide Chemistry
Molecules, 2014 The use of chemical ligation within the realm of peptide chemistry has opened various opportunities to expand the applications of peptides/proteins in biological sciences.
Parashar Thapa +3 more
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Exploring the sequence diversity of cyclotides from Vietnamese Viola species
, 2020 is the largest genus in the Violaceae plant family and is known for its ubiquitous natural production of cyclotides. Many species are used as medicinal herbs across Asia and are often consumed by humans in teas for the treatment of diseases, including ...
Chan, Lai Y. +6 more
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Recombinant Production of The Cyclotide Kalata B1 by Conditional Split Inteins
ChemBioChem, Volume 26, Issue 4, February 16, 2025.A workflow to generate cyclic peptides from easily obtainable precursor proteins was established. The peptide is embedded in a split intein system that can be expressed in E. coli and purified via IMAC. Simply mixing the two precursor proteins starts conversion at will, yielding cyclic peptides.
Abdulkadir Yayci +3 more
wiley +1 more source
Chemical Proteomics for Target Discovery of Head-to-Tail Cyclized Mini-Proteins
Frontiers in Chemistry, 2017 Target deconvolution is one of the most challenging tasks in drug discovery, but a key step in drug development. In contrast to small molecules, there is a lack of validated and robust methodologies for target elucidation of peptides.
Roland Hellinger +9 more
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Navigating a 1E+60 Chemical Space of Peptide/Peptoid Oligomers
Molecular Informatics, Volume 44, Issue 1, January 2025.Herein we report a virtual library of 1E+60 members, a common estimate for the size of the drug‐like chemical space. The library consists of linear or cyclic oligomers forming molecules within the size range of peptide drugs. We demonstrate ligand‐based virtual screening using a genetic algorithm.
Markus Orsi, Jean‐Louis Reymond
wiley +1 more source
Chemical and Biological Production of Cyclotides [PDF]
, 2015 Cyclotides are fascinating naturally occurring micro-proteins (≈30 residues long) present in several plant families, and display various biological properties such as protease inhibitory, anti-microbial, insecticidal, cytotoxic, anti-HIV and hormone-like activities.
Yilong, Li, Tao, Bi, Julio A, Camarero
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Medicines, 2019 Background: Novel strategies to increase the efficacy of antiretroviral (ARV) drugs will be of crucial importance. We hypothesize that membranes of HIV-1-infected cells and enveloped HIV-1 particles may be preferentially targeted by the phytopeptide ...
Samantha L. Gerlach +7 more
doaj +1 more source
Topical Delivery Systems for Plant‐Derived Antimicrobial Agents: A Review of Current Advances
International Journal of Biomaterials, Volume 2025, Issue 1, 2025.Plant‐derived compounds have attracted considerable attention in the field of antimicrobial therapy. This interest is primarily due to their natural origin and historical evidence of their use in traditional medicine systems. These derivatives are a rich reservoir of chemical diversity that has a promising potential for the development and production ...
Mohammad Hashem Hashempur +10 more
wiley +1 more source