Results 81 to 90 of about 1,652 (193)

Display Technologies for Expanding the Pharmaceutical Applications of Cyclotides

Israel Journal of Chemistry, Volume 64, Issue 8-9, September 2024.
Abstract Cyclotides are ultra‐stable peptides originally discovered in plants based on their medicinal applications. Their natural function is as host defence agents. They are amenable to chemical synthesis for use as scaffolds for drug design applications.
Jing Xie, Meng‐Wei Kan, Simon J. de Veer, Conan Wang, David J. Craik   +4 more
wiley   +1 more source

Peptídeos cíclicos de biomassa vegetal: características, diversidade, biossíntese e atividades biológicas Cyclic peptide from plant biomass: chemical features and diversity, biosynthesis and biological activities

Química Nova, 2009
Natural peptides are outstanding as the most promising macromolecules in the search for new drugs, especially those of cyclic nature. The higher plants revealed a very peculiar composition of their cyclic peptides, which distinguish themselves by a "head-
Douglas Gatte Picchi, Wanessa Fernanda Altei, Mônica Sue Saito, Vanderlan da Silva Bolzani, Eduardo Maffud Cilli   +4 more
doaj   +1 more source

Natural functions and structure-activity relationships of cyclotides

, 2015
Cyclotides have a diverse range of biological activities that have both pharmaceutical and agricultural applications. Here we examine the range of activities seen in natural cyclotides and describe the structure-activity relationship (SAR) studies that ...
Georgianna Kae Oguis, Kan, Meng-Wei, Oguis, Georgianna Kae, Meng-Wei Kan, David J. Craik, Craik, David J.   +5 more
core   +1 more source

Protein Grafting Techniques: From Peptide Epitopes to Lasso‐Grafted Neobiologics

ChemPlusChem, Volume 89, Issue 8, August 2024.
The idea of grafting small peptide pharmacophores onto larger protein scaffolds, thus harvesting the advantages of both, has given rise to a variety of protein engineering strategies that are reviewed herein. We also describe our own “Lasso‐Grafting” approach, which combines traditional grafting concepts with mRNA display to streamline the production ...
Mikio Imai, Kilian Colas, Hiroaki Suga
wiley   +1 more source

Identification of Cyclotides From Butterfly Pea () Petals and Its Biological Activities

Natural Product Communications
Background Cyclotides are macrocyclic peptides characterized by a head-to-tail cyclized backbone and a cyclic cystine knot motif, and are found in the petals of butterfly pea ( Clitoria ternatea ). Objective Clitoria ternatea cv. “Theparatpailin 63” is a
Naoki Ikeda, Hikari Matsumura, Arisa Kajiwara, Yukihiko Nakagawa, Machiko Kondo, Ken-ichi Kubo, Akihisa Tsuji, Fang-Sik Che   +7 more
doaj   +1 more source

Classes, Databases, and Prediction Methods of Pharmaceutically and Commercially Important Cystine-Stabilized Peptides

Toxins, 2018
Cystine-stabilized peptides represent a large family of peptides characterized by high structural stability and bactericidal, fungicidal, or insecticidal properties.
S M Ashiqul Islam, Christopher Michel Kearney, Erich Baker   +2 more
doaj   +1 more source

Anti-HIV Cyclotides from the Chinese Medicinal Herb Viola yedonensis

, 2008
Cyclotides are macrocyclic plant peptides characterized by a knotted arrangement of three disulfide bonds. They display a range of interesting bioactivities, including anti-HIV and insecticidal activities.
Ireland, David C., Colgrave, Michelle L., Goransson, Ulf, Craik, David J., Gustafson, Kirk R., Wang, Conan K. L.   +5 more
core   +1 more source

Strategies of plants to overcome abiotic and biotic stresses

Biological Reviews, Volume 99, Issue 4, Page 1524-1536, August 2024.
ABSTRACT In their environment, plants are exposed to a multitude of abiotic and biotic stresses that differ in intensity, duration and severity. As sessile organisms, they cannot escape these stresses, but instead have developed strategies to overcome them or to compensate for the consequences of stress exposure.
Baoguo Du, Robert Haensch, Saleh Alfarraj, Heinz Rennenberg   +3 more
wiley   +1 more source

Discovery of cyclotides from Australasian plants

, 2020
This article is part of a special issue celebrating the contributions of Professor Paul Alewood to peptide science. We begin by providing a summary of collaborative projects between the Alewood and Craik groups at The University of Queensland and ...
Kan, Meng-Wei, Craik, David J.
core   +1 more source

Molecular farming for sustainable production of clinical‐grade antimicrobial peptides

Plant Biotechnology Journal, Volume 22, Issue 8, Page 2282-2300, August 2024.
Summary Antimicrobial peptides (AMPs) are emerging as next‐generation therapeutics due to their broad‐spectrum activity against drug‐resistant bacterial strains and their ability to eradicate biofilms, modulate immune responses, exert anti‐inflammatory effects and improve disease management. They are produced through solid‐phase peptide synthesis or in
Shahid Chaudhary, Zahir Ali, Magdy Mahfouz   +2 more
wiley   +1 more source