Results 91 to 100 of about 1,652 (193)
Structure and Activity of Reconstructed Pseudo‐Ancestral Cyclotides
ChemMedChem, Volume 19, Issue 14, July 15, 2024.Ancestral sequence reconstruction was used to predict two ancestral cyclotides, Ancy‐m and Ancy‐b. These two predicted ancestors maintained their stability and activities. Meanwhile, Ancy‐b had an improved folding yield over the prototypical bracelet cyclotide.
Zhihao Jiang +4 more
wiley +1 more source
ChemBioChem, Volume 25, Issue 3, February 1, 2024.The biosynthetic pathway for the peptide natural product omphalotin A of the agaricomycete Omphalotus olearius can be exploited for the production of non‐natural, multiply backbone N‐methylated peptide macrocycles in the yeast Pichia pastoris (Komagataella phaffii).
Emmanuel Matabaro +5 more
wiley +1 more source
Cyclotides Suppress Human T-Lymphocyte Proliferation by an Interleukin 2-Dependent Mechanism.
PLoS ONE, 2013 Cyclotides are a diverse and abundant group of ribosomally synthesized plant peptides containing a unique cyclic cystine-knotted topology that confers them with remarkable stability. Kalata B1, a representative member of this family of mini-proteins, has
Carsten Gründemann +8 more
doaj +1 more source
Discovery and Characterization of Cyclotides from Rinorea Species
, 2018 Cyclotides are macrocyclic cystine-knotted peptides most commonly found in the Violaceae plant family. Although Rinorea is the second-largest genera within the Violaceae family, few studies have examined whether or not they contain cyclotides. To further
Lai Yue Chan (468091) +11 more
core +1 more source
Cyclic Peptides for Drug Development
Angewandte Chemie, Volume 136, Issue 3, January 15, 2024.Cyclic peptides combine a number of favorable properties that make them attractive for drug development. Today, more than 40 therapeutics based on cyclic peptides are in use, and new, powerful technologies for their development suggest that this number could grow rapidly.
Xinjian Ji +2 more
wiley +1 more source
Discovery and characterization of cyclotides from Rinorea species
, 2018 Cyclotides are macrocyclic cystine-knotted peptides most commonly found in the Violaceae plant family. Although Rinorea is the second-largest genera within the Violaceae family, few studies have examined whether or not they contain cyclotides. To further
Harvey, Peta J. +5 more
core +1 more source
Cyclotides: disulfide-rich peptide toxins in plants
, 2019 Cyclotides are a plant-derived family of peptides that comprise approximately 30 amino acid residues, a cyclic backbone and a cystine knot. Due to their unique structure, cyclotides are exceptionally stable to heat or proteolytic degradation and are ...
Du, Qingdan +2 more
core +1 more source
Joseph Rudinger memorial lecture: discovery and applications of cyclotides
, 2013 Cyclotides are plant-derived peptides of approximately 30 amino acids that have the characteristic structural features of a head-to-tail cyclized backbone and a cystine knot arrangement of their three conserved disulfide bonds.
David J Craik, Craik, David J.
core +1 more source
Chemical Synthesis and Functional Analysis of VarvA Cyclotide
Molecules, 2018 Cyclotides are circular peptides found in various plant families. A cyclized backbone, together with multiple disulfide bonds, confers the peptides’ exceptional stability against protease digestion and thermal denaturation.
Claudio A. Álvarez +6 more
doaj +1 more source
Lysine-rich cyclotides: a new subclass of circular knotted proteins from violaceae
, 2015 Cyclotides are macrocyclic proteins produced by plants for host defense. Although, they occur sparsely in other plant cyclotides have been detected in every Violaceae plant species so far screened.
Colgrave, Michelle L. +13 more
core +1 more source