Results 81 to 90 of about 578 (154)

Variations in cyclotide expression in Viola species

, 2004
Cyclotides, a family of approximately 50 mini-proteins isolated from various Violaceae and Rubiaceae plants, are characterized by their circular peptide backbone and six conserved cysteine residues arranged in a cystine knot motif. Cyclotides show a wide
Herrmann, A., Claeson, Per,, Claeson, P., Bohlin, Lars,, Herrmann, Anders,, Bohlin, L., Svangard, E., Craik, D. J., Trabi, Manuela, Craik, David J, Trabi, M., Goransson, U., Göransson, Ulf,, Svangård, Erika,   +13 more
core   +1 more source

Structure and Activity of Reconstructed Pseudo‐Ancestral Cyclotides

ChemMedChem, Volume 19, Issue 14, July 15, 2024.
Ancestral sequence reconstruction was used to predict two ancestral cyclotides, Ancy‐m and Ancy‐b. These two predicted ancestors maintained their stability and activities. Meanwhile, Ancy‐b had an improved folding yield over the prototypical bracelet cyclotide.
Zhihao Jiang, Yen‐Hua Huang, Quentin Kaas, David J. Craik, Conan K. Wang   +4 more
wiley   +1 more source

Exploring the Interaction Mechanism Between Cyclopeptide DC3 and Androgen Receptor Using Molecular Dynamics Simulations and Free Energy Calculations

Frontiers in Chemistry, 2018
Androgen receptor (AR) is a key target in the discovery of anti-PCa (Prostate Cancer) drugs. Recently, a novel cyclopeptide Diffusa Cyclotide-3 (DC3), isolated from Hedyotisdiffusa, has been experimentally demonstrated to inhibit the survival and growth ...
Huimin Zhang, Tianqing Song, Yizhao Yang, Chenggong Fu, Jiazhong Li   +4 more
doaj   +1 more source

Promiscuity of Omphalotin A Biosynthetic Enzymes Allows de novo Production of Non‐Natural Multiply Backbone N‐Methylated Peptide Macrocycles in Yeast

ChemBioChem, Volume 25, Issue 3, February 1, 2024.
The biosynthetic pathway for the peptide natural product omphalotin A of the agaricomycete Omphalotus olearius can be exploited for the production of non‐natural, multiply backbone N‐methylated peptide macrocycles in the yeast Pichia pastoris (Komagataella phaffii).
Emmanuel Matabaro, Luca Witte, Fabio Gherlone, Eva Vogt, Hannelore Kaspar, Markus Künzler   +5 more
wiley   +1 more source

In Vivo Activation of the p53 Tumor Suppressor Pathway by an Engineered Cyclotide

, 2016
The overexpression of Hdm2 and HdmX is a common mechanism used by many tumor cells to inactive the p53 tumor suppressor pathway promoting cell survival.
Radhika Borra (1927993), Ahmed Y. Elnagar (1927990), Melissa Millard (275631), Alexander Shekhtman (87269), Subhabrata Majumder (1606492), Julio A. Camarero (1346460), Yanbin Ji (1927987), Tao Bi (1346454), Nouri Neamati (275633)   +8 more
core   +1 more source

Cyclic Peptides for Drug Development

Angewandte Chemie, Volume 136, Issue 3, January 15, 2024.
Cyclic peptides combine a number of favorable properties that make them attractive for drug development. Today, more than 40 therapeutics based on cyclic peptides are in use, and new, powerful technologies for their development suggest that this number could grow rapidly.
Xinjian Ji, Alexander L. Nielsen, Christian Heinis   +2 more
wiley   +1 more source

Cyclotides Suppress Human T-Lymphocyte Proliferation by an Interleukin 2-Dependent Mechanism.

PLoS ONE, 2013
Cyclotides are a diverse and abundant group of ribosomally synthesized plant peptides containing a unique cyclic cystine-knotted topology that confers them with remarkable stability. Kalata B1, a representative member of this family of mini-proteins, has
Carsten Gründemann, Kathrin Thell, Karin Lengen, Manuel Garcia-Käufer, Yen-Hua Huang, Roman Huber, David J Craik, Gernot Schabbauer, Christian W Gruber   +8 more
doaj   +1 more source

Oxidative folding of the cystine knot motif in cyclotide proteins

, 2005
The cyclotides are a large family of plant proteins that have a cyclic backbone and a knotted arrangement of three conserved disulfide bonds. Despite the apparent complexity of their cystine knot motif it is possible to efficiently fold these proteins ...
Daly, NL, Craik, DJ
core   +1 more source

A systematic approach to document cyclotide distribution in plant species from genomic, transcriptomic and peptidomic analysis

, 2013
Cyclotides are a large family of plant peptides characterized by their cyclic cystine knot composed of a circular backbone and three disulfide bonds that impart exceptional stability.
Gruber, Christian W., Göransson, Ulf, Craik, David J., Christian W. Gruber, Debasis Mondal, Ulf Göransson, Quentin Kaas, Kaas, Quentin, Göransson, Ulf,, David J. Craik, Gerlach, Samantha L., Mondal, Debasis, Samantha L. Gerlach   +12 more
core   +1 more source

Interpopulational Variation in Cyclotide Production in Heavy-Metal-Treated Pseudometallophyte (Viola tricolor L.)

Plants
It remains an open question whether violets use universal mechanisms, such as the production of metallothioneins, phytochelatins, and organic acids and/or rely on specific mechanisms like the production of antimicrobial cyclic peptides (cyclotides) for ...
Rebecca Miszczak, Blazej Slazak, Klaudia Sychta, Ulf Göransson, Anna Nilsson, Aneta Słomka   +5 more
doaj   +1 more source