Results 91 to 100 of about 879 (125)

Distribution of 14C cylindrospermopsin in vivo in the mouse

Environmental Toxicology, 2001
AbstractRadiolabelled 14C cylindrospermopsin (CYN) has been prepared and used to investigate the distribution and excretion of CYN in vivo in male Quackenbush mice. At a dose of 0.2 mg/kg (i.e., approx. median lethal dose) the following mean (SD) urinary and faecal recoveries (cumulative) were obtained, respectively: (0–6 hours, n=4) 48.2 (29.3)%, 11.9
Norris, R.G.L., Seawright, A.A., Shaw, Glendon Reginald, Smith, M.J., Chiswell, R.K., Moore, M.R.   +5 more
openaire   +5 more sources

Synthetic Studies on a Model of Cylindrospermopsin

Synlett, 2007
A new strategy for the synthesis of cylindrospermopsin is described using an intramolecular Mannich reaction to form ring A. Guanylation of the piperidine nitrogen and reaction on an activated double bond generates ring B.
Yves Troin, Helene Henon
openaire   +1 more source

ChemInform Abstract: The Cylindrospermopsin Alkaloids

ChemInform, 2012
AbstractReview: 209 refs.
Daniel M. Evans, Patrick J. Murphy
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Hepatic xenobiotic metabolism of cylindrospermopsin in vivo in the mouse

Toxicon, 2002
Cylindrospermopsin (CYN) is a hepatotoxin isolated from the blue-green alga Cylindrospermopsis raciborskii. The role of both glutathione (GSH) and the cytochrome P450 enzyme system (P450) in the mechanism of toxicity of CYN has been previously investigated in in vitro systems. We have investigated the role of GSH and P450 in vivo in mice.
Norris, R., Seawright, A., Shaw, G., Senogles, P., Eaglesham, G., Smith, M., Chiswell, R., Moore, M.   +7 more
openaire   +5 more sources

Sorption of the cyanobacterial toxins cylindrospermopsin and anatoxin-a to sediments

Water Research, 2011
The occurrence of the cyanobacterial toxins anatoxin-a (ATX) and cylindrospermopsin (CYN) in surface waters has been reported throughout the world. Beside degradation, sorption is an important pathway for toxin elimination if these resources are used for drinking water production via sediment passage.
Klitzke, Sondra, Beusch, Christine, Fastner, Jutta   +2 more
openaire   +3 more sources

Cylindrospermopsin effects on protein profile of HepG2 cells

Toxicology Mechanisms and Methods, 2016
Human hepatoma cells (HepG2) were exposed to purified cylindrospermopsin (CYN), a potent toxicant for eukaryotic cells produced by several cyanobacteria. Exposure to 10 μg l-1 of CYN for 24 h resulted in alteration of expression of 48 proteins, from which 26 were identified through mass spectrometry.
Samuel, Liebel, Sonia, Regina Grötzner, Daniele, Dietrich Moura Costa, Marco, Antônio Ferreira Randi, Ciro, Alberto de Oliveira Ribeiro, Francisco, Filipak Neto   +5 more
openaire   +2 more sources

Evaluation of the intestinal permeability and cytotoxic effects of cylindrospermopsin

Toxicon, 2014
Cylindrospermopsin is a freshwater and widespread cyanotoxin considered hazardous for human health. Climate change and eutrophication are the main factors influencing the increasing presence of cylindrospermopsin producers that can contaminate human and animal drinking waters, leading to a rise in ecological and human risk.
Diego A. Fernández, M. Carmen Louzao, Natalia Vilariño, Maria Fraga, Begoña Espiña, Mercedes R. Vieytes, Luis M. Botana   +6 more
openaire   +2 more sources

Biodegradation of the cyanotoxin cylindrospermopsin

Synopsis Blooms of the cyanobacterium Cylindrospermopsis raciborskii have become a reoccurring feature of our waterways and storages worldwide. These blooms have the potential to threaten the health of both humans and animals through the contamination of recreational and drinking water supplies. C.
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Synthesis of Cylindrospermopsin

Synfacts, 2006
R. Williams, R. Looper, M. Runnegar
openaire   +1 more source

In vitro study of mutagenicity of cylindrospermopsin and cytotoxic effects of the combination of microcystin and cylindrospermopsin

Toxicology Letters, 2016
A. Jos, D. Gutiérrez Praena, S. Maisanaba, M. Llana Ruíz Cabello, A. Cameán   +4 more
openaire   +1 more source