Results 81 to 90 of about 3,601 (247)

In-vitro Toxicity Study of Cylindrospermopsin on Wistar Rats [PDF]

, 2019
Naturally derived cyanotoxin, Cylindrospermopsin (CYN) found in fresh water systems poses a threat to human health worldwide. Cylindrospermopsin (CYN) is most potent cyanotoxin which affects the functions of kidney and liver.
Abeysiri, H.A.S.N., Manage, S.P., Suresh, T.S., Manage, P.M., Abinaiyan, I., Wanigasuriya, K., Dilrukshi, K.T.   +6 more
core   +1 more source

Peroxynitrite is key to Cylindrospermopsin-mediated MASLD to MASH progression via triggering TXNIP binding to NLRP3 and subsequent inflammasome activation.

Toxicology and Applied Pharmacology
Harmful algal bloom (HAB) toxins are shown to be associated with Metabolic dysfunction-associated steatohepatitis (MASH) progression. Several studies link the HAB toxin microcystin to hepatic inflammasome activation, but the role of cylindrospermopsin ...
P. Saha, Dipro Bose, Subhajit Roy, M. More, Ayushi Trivedi, Bryan W. Brooks, Shuo Xiao, Wing K. Syn, A. M. Diehl, Saurabh Chatterjee   +9 more
semanticscholar   +1 more source

Occurrence of the cyanobacterial toxin cylindrospermopsin in northeast Germany [PDF]

Environmental Toxicology, 2007
AbstractThe frequent occurrence of the cyanobacterial toxin cylindrospermopsin (CYN) in the (sub)tropics has been largely associated with cyanobacteria of the order Nostocales of tropical origin, in particular Cylindrospermopsis raciborskii. C. raciborskii is currently observed to spread northwards into temperate climatic zones.
Jutta, Fastner, Jacqueline, Rücker, Anke, Stüken, Karina, Preussel, Brigitte, Nixdorf, Ingrid, Chorus, Antje, Köhler, Claudia, Wiedner   +7 more
openaire   +2 more sources

Induction of p53-Regulated Gene Expression in Human Cell Lines Exposed to the Cyanobacterial Toxin Cylindrospermopsin

, 2007
Cylindrospermopsin (CYN) is a cyanobacterial toxin that induces a range of genotoxic indicators in a variety of models. The possible involvement of the tumor suppressor protein p53 in cylindrospermopsin-induced gene expression was examined in cultured ...
Shaw, Glen, Shaw, Glendon, Bain, Peter, Patel, Bharat   +3 more
core   +1 more source

Multimodal Cross‐Attentive Graph‐Based Framework for Predicting In Vivo Endocrine Disruptors

Advanced Science, Volume 13, Issue 21, 13 April 2026.
A multimodal cross‐attentive graph neural network integrates molecular graphs with androgen and estrogen adverse outcome pathway (AOP)–anchored in vitro assay signals to predict in vivo endocrine disruption. By fusing information on Tier‐1 AOP logits with chemical structures, the framework achieves high accuracy and provides assay‐traceable ...
Eder Soares de Almeida Santos, Gustavo Felizardo Santos Sandes, Artur Christian Garcia da Silva, Holli‐Joi Martin, Eugene N. Muratov, Rodolpho de Campos Braga, Bruno Junior Neves   +6 more
wiley   +1 more source

Cylindrospermopsin: A Decade of Progress on Bioaccumulation Research [PDF]

Marine Drugs, 2010
Cylindrospermopsin (CYN) is rapidly being recognised as one of the most globally important of the freshwater algal toxins. The ever-expanding distribution of CYN producers into temperate zones is heightening concern that this toxin will represent serious human, as well as environmental, health risks across many countries.
openaire   +4 more sources

First report of the cyanobacterial toxin cylindrospermopsin in New Zealand

, 2001
Cylindrospermopsin, a hepatotoxin produced by cyanobacteria, has been unambiguously detected in cyanobacteria collected from a recreational lake in the Wellington region of New Zealand.
Quilliam, Michael A., Stirling, David J., David J. Stirling, Michael A. Quilliam   +3 more
core   +1 more source

Cellular responses of Prochilodus lineatus hepatocytes after cylindrospermopsin exposure [PDF]

, 2011
Cylindrospermopsin is a potent toxicant for eukaryotic cells produced by several cyanobacteria. Recently, primary hepatocyte cultures of Neotropical fish have been established, demonstrating to be a quite efficient in vitro model for cellular toxicology ...
Ramsdorf, W.A., M.M. Cestari, Liebel, S., Cestari, M.M., Magalhães, V.F., B.M. Esquivel, Oliveira Ribeiro, C.A., Esquivel, B.M., Filipak Neto, F., Garcia, J.R.E., S. Liebel, Silva, R.C., R.C. Silva, W.A. Ramsdorf, F. Filipak Neto, J.R.E. Garcia, V.F. Magalhães, C.A. Oliveira Ribeiro   +17 more
core   +1 more source

Interactive effects of cyanobacterial metabolites aeruginosin-98B, anabaenopeptin-B and cylindrospermopsin on physiological parameters and novel in vivo fluorescent indicators in Chironomus aprilinus larvae.

Science of the Total Environment
We aimed to determine the effects of single cyanobacterial metabolites aeruginosin-B (AER-B), anabaenopeptin-B (ANA-B), cylindrospermopsin (CYL), their binary and ternary mixtures on biomarkers of Chironomus aprilinus larvae: oxygen consumption, fat body
A. Bownik, B. Pawlik-Skowrońska, Donald Włodkowic, Tomasz Mieczan   +3 more
semanticscholar   +1 more source

Statewide Intensification of Harmful Algal Blooms Across California Lakes and Reservoirs

GeoHealth, Volume 10, Issue 4, April 2026.
Abstract Monitoring cyanobacteria is crucial for assessing water quality, safeguarding public health, and understanding ecosystem dynamics impacted by harmful algal blooms. This study explores the potential of satellite remote sensing (SRS) to assess risks of cyanotoxin exposure in California's recreational waters from 2002 to 2011 and 2016 to 2023 ...
Brittany N. Barreto Martinez, Erin L. Hestir, Marc W. Beutel, Christine M. Lee   +3 more
wiley   +1 more source