Results 81 to 90 of about 879 (125)

Total Synthesis of (±)-Cylindrospermopsin

Journal of the American Chemical Society, 2000
The first total synthesis of the novel hepatotoxin (±)-cylindrospermopson (1) has been accomplished in 20 steps from 4-methoxy-3-methylpyridine (12) in 3.5% overall yield. The substituted piperidine A ring 19 was generated stereospecifically by a four-step sequence using the addition of trimethylsilylethynylmagnesium bromide to 12 to give 16 and ...
Chaoyu Xie, Maria T. C. Runnegar, Barry B. Snider   +2 more
openaire   +1 more source

Syntheses of the cylindrospermopsin alkaloids

Tetrahedron, 2006
Abstract An intramolecular 1,3-dipolar cycloaddition has efficiently constructed the A-ring portions of the cylindrospermopsin alkaloids. A nitro-aldol addition of an elaborated nitroalkane to a pyrimidine aldehyde followed by an intramolecular reductive guanidinylation has enabled the syntheses of all three alkaloids in this family in 18–19 steps ...
Ryan E. Looper, Maria T.C. Runnegar, Robert M. Williams   +2 more
openaire   +1 more source

Interlaboratory comparison trial on cylindrospermopsin measurement

Analytical Biochemistry, 2004
The hepatotoxin cylindrospermopsin (CYN) is a potent inhibitor of protein synthesis in mammalian cells. It is produced by freshwater cyanobacterial blooms in countries such as Australia, the United States, Israel, Thailand, and Brazil. An interlaboratory comparison was organized as a first step to evaluate the measurement of CYN in lyophilized ...
Andrea, Törökné, Maria, Asztalos, Maria, Bánkiné, Heike, Bickel, Georg, Borbély, Shmuel, Carmeli, Geoffrey A, Codd, Jutta, Fastner, Qiong, Huang, Andrew, Humpage, James S, Metcalf, Erzsebet, Rábai, Assaf, Sukenik, Gyula, Surányi, Gabor, Vasas, Viktor, Weiszfeiler   +15 more
openaire   +2 more sources

Genotoxicity investigation of a cyanobacterial toxin, cylindrospermopsin

Toxicon, 2002
Cylindrospermopsin (CYN), a potent cyanobacterial hepatotoxin produced by Cylindrospermopsis raciborskii and other cyanobacteria, is regularly found in water supplies in many parts of the world, and has been associated with the intoxication of humans and livestock.
Shen, X. Y., Lam, P. K. S., Shaw, G. R., Wickramasinghe, W.   +3 more
openaire   +5 more sources

Biosynthesis of Cylindrospermopsin in Cyanobacteria: Characterization of CyrJ the Sulfotransferase

Journal of Natural Products, 2021
7-Deoxy-desulfo-cylindrospermopsin was purified at small-scale from the supernatant of a culture of the cyanobacterium Oscillatoria sp. PCC 10702. This metabolite was obtained in a pure form using a three-step chromatographic procedure, and its identity was confirmed by liquid chromatography-tandem mass spectrometry (LC-MS/MS).
Annick Méjean, Olivier Ploux
openaire   +2 more sources

HPLC-PDA detection of cylindrospermopsin—opportunities and limits

Water Research, 2002
The cyanobacterial hepatotoxic alkaloid cylindrospermopsin (CYL) is of increased concern to public health due to the spreading of its main producer, Cylindrospermopsis raciborskii, around the globe. Here we present results of an evaluation of the possibility to analyse environmental samples for their content of CYL based on HPLC with photo diode array ...
Martin Welker, Jutta Fastner
exaly   +3 more sources

First occurrence of cylindrospermopsin in freshwater in France

Environmental Toxicology, 2008
AbstractEleven waterbodies in Western France dominated by cyanobacteria of the genera Aphanizomenon and Anabaena were analyzed in September 2006 for microcystins (MC) and cylindrospermopsin (CYN). CYN was detected for the first time in France in four of them in the presence of Aphanizomenon flos‐aquae and in the presence of Anabaena planctonica in the ...
Brient, Luc, Lengronne, Marion, Bormans, Myriam, Fastner, Jutta   +3 more
openaire   +4 more sources

Cytotoxicity Screening for the Cyanobacterial Toxin Cylindrospermopsin

Journal of Toxicology and Environmental Health, Part A, 2009
The cell lines C3A, HepG2, NCI-87, HCT-8, HuTu-80, Caco-2, and Vero were screened for sensitivity to the cyanobacterial toxin cylindrospermopsin (CYN), with the aim of determining the most sensitive cells to be used in cytotoxicity tests. Cell lines were chosen to be representative of the organs targeted by the toxin; liver, kidney, intestine, and were
Froscio, S., Fanok, S., Humpage, A.
openaire   +3 more sources

Toxicity of the cyanobacterial toxin, cylindrospermopsin in mammals

Toxicology, 2000
Griffith Health Faculty ; No Full ...
Seawright, A. A., Norris, R. L., Shaw, G. R., Moore, M., Burgess, V.   +4 more
openaire   +3 more sources

Total Synthesis of rac‐Cylindrospermopsin

ChemInform, 2005
AbstractFor Abstract see ChemInform Abstract in Full Text.
Barry B. Snider, Chaoyu Xie
openaire   +1 more source