Results 111 to 120 of about 294 (139)
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Total Synthesis of rac‐Cylindrospermopsin
ChemInform, 2005AbstractFor Abstract see ChemInform Abstract in Full Text.
Barry B. Snider, Chaoyu Xie
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Distribution of 14C cylindrospermopsin in vivo in the mouse
Environmental Toxicology, 2001AbstractRadiolabelled 14C cylindrospermopsin (CYN) has been prepared and used to investigate the distribution and excretion of CYN in vivo in male Quackenbush mice. At a dose of 0.2 mg/kg (i.e., approx. median lethal dose) the following mean (SD) urinary and faecal recoveries (cumulative) were obtained, respectively: (0–6 hours, n=4) 48.2 (29.3)%, 11.9
Norris, R.G.L. +5 more
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Evaluation of the intestinal permeability and cytotoxic effects of cylindrospermopsin
Toxicon, 2014Cylindrospermopsin is a freshwater and widespread cyanotoxin considered hazardous for human health. Climate change and eutrophication are the main factors influencing the increasing presence of cylindrospermopsin producers that can contaminate human and animal drinking waters, leading to a rise in ecological and human risk.
Diego A. Fernández +6 more
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ChemInform Abstract: The Cylindrospermopsin Alkaloids
ChemInform, 2012AbstractReview: 209 refs.
Daniel M. Evans, Patrick J. Murphy
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Synthetic Studies on a Model of Cylindrospermopsin
Synlett, 2007A new strategy for the synthesis of cylindrospermopsin is described using an intramolecular Mannich reaction to form ring A. Guanylation of the piperidine nitrogen and reaction on an activated double bond generates ring B.
Yves Troin, Helene Henon
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Hepatic xenobiotic metabolism of cylindrospermopsin in vivo in the mouse
Toxicon, 2002Cylindrospermopsin (CYN) is a hepatotoxin isolated from the blue-green alga Cylindrospermopsis raciborskii. The role of both glutathione (GSH) and the cytochrome P450 enzyme system (P450) in the mechanism of toxicity of CYN has been previously investigated in in vitro systems. We have investigated the role of GSH and P450 in vivo in mice.
Norris, R. +7 more
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Sorption of the cyanobacterial toxins cylindrospermopsin and anatoxin-a to sediments
Water Research, 2011The occurrence of the cyanobacterial toxins anatoxin-a (ATX) and cylindrospermopsin (CYN) in surface waters has been reported throughout the world. Beside degradation, sorption is an important pathway for toxin elimination if these resources are used for drinking water production via sediment passage.
Klitzke, Sondra +2 more
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Cylindrospermopsin effects on protein profile of HepG2 cells
Toxicology Mechanisms and Methods, 2016Human hepatoma cells (HepG2) were exposed to purified cylindrospermopsin (CYN), a potent toxicant for eukaryotic cells produced by several cyanobacteria. Exposure to 10 μg l-1 of CYN for 24 h resulted in alteration of expression of 48 proteins, from which 26 were identified through mass spectrometry.
Samuel, Liebel +5 more
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Natural Photodegradation of the Cyanobacterial Toxins Microcystin and Cylindrospermopsin
Environmental Science & Technology, 2010Microcystins (MC) and cylindrospermopsin (CYN) are potent toxins produced by diverse cyanobacterial genera found in waterbodies throughout the world. In the present study, and in order to achieve a better understanding of the fate of cyanobacterial toxins in the environment, we assessed the photodegradation of MC and CYN along the water column and by ...
Lars, Wörmer +4 more
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Biodegradation of the cyanotoxin cylindrospermopsin
Synopsis Blooms of the cyanobacterium Cylindrospermopsis raciborskii have become a reoccurring feature of our waterways and storages worldwide. These blooms have the potential to threaten the health of both humans and animals through the contamination of recreational and drinking water supplies. C.openaire +2 more sources