Results 151 to 160 of about 2,702,703 (186)

Association of the CYP17 gene and CYP19 gene polymorphisms with risk of endometriosis in Japanese women. [PDF]

Human Reproduction, 2002
To investigate whether polymorphisms of CYP17 and CYP19 genes are associated with the risk of endometriosis, we analysed the frequency and distribution of a single nucleotide polymorphism at the 5' untranslated region of the CYP17 gene, and a tetranucleotide (TTTA) tandem repeat polymorphism and a 3 bp insertion (I)/deletion (D) polymorphism in intron ...
Jo Kitawaki, Hiroaki Ishihara, Hideo Honjo   +2 more
exaly   +3 more sources

CYP19 gene: a genetic modifier of polycystic ovary syndrome phenotype

Fertility and Sterility, 2010
To evaluate the possible contribution of the (TTTA)n polymorphism of aromatase gene (CYP19) to the hyperandrogenic phenotype of polycystic ovary syndrome (PCOS).Case-control study.Endocrine outpatients' clinic of a tertiary university hospital.One hundred eighty women with PCOS and 160 healthy controls of reproductive age.Blood sampling for genotype ...
Ioannis Georgiou, Agathocles Tsatsoulis, Nectaria Xita   +2 more
exaly   +4 more sources

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CYP19 gene polymorphism in endometrial cancer patients

Journal of Cancer Research and Clinical Oncology, 2001
Initiation/promotion of endometrial cancer is known to be associated with estrogenic influence. Therefore, it is possible that some allelic polymorphisms of the genes involved in steroidogenesis or steroid metabolism contribute to endometrial cancer susceptibility.Here, we compared CYP19 (aromatase) gene polymorphism in 85 endometrial cancer patients ...
Evgeny N Suspitsin, Evgeny N Imyanitov, T E Poroshina   +2 more
exaly   +3 more sources

Characterization of duplicated zebrafish cyp19 genes

Journal of Experimental Zoology, 2001
AbstractThe zebrafish has recently been developed as a good genetic model system. We report here the use of zebrafish to study the regulation of estrogen biosynthesis. The CYP19 gene encodes cytochrome P450 aromatase, which catalyzes the synthesis of estrogens. Two cyp19 genes, termed cyp19a and cyp19b, have been isolated from zebrafish.
Chiang, E.F.L., Yan, Y.L., Tong, S.K., Hsiao, P.H., Guiguen, Yann, Postlethwait, John, Chung, B.C.   +6 more
openaire   +3 more sources

Genetic Profiling of CYP19 Gene Haplotype in Holstein Bulls

Indian Journal of Forensic Medicine & Toxicology, 2021
The CYP19 gene is a protein-coding gene that stimulates the transmutation of androgens to estrogens,aromatase activity is related to haplotypes of the CYP19 gene, therefore this study aimed to detect haplotypesof the CYP19 gene in the Holstein bulls. This study, conducted from October 2018 to June 2019.
null Hassan Nima Habib, null Khalaf A.H.Al-Rishdy, null Murthda F.AL-Hellou   +2 more
openaire   +1 more source

The (TTTA)n polymorphism of aromatase (CYP19) gene is associated with age at menarche. [PDF]

Human Reproduction, 2010
Twin studies have shown that age at menarche may be subject to hereditary influences but the specific determinants are unknown. Estrogens are known to have an important role in menarche. Since the enzyme aromatase is responsible for the conversion of androgens to estrogens, the aromatase (CYP19) gene could be a candidate gene for the regulation of ...
N Xita, A Tsatsoulis
exaly   +4 more sources

Organization of the Human Aromatase P450 (CYP19) Gene

Seminars in Reproductive Medicine, 2004
The human CYP19 (p450arom) gene is located in the 21.2 region on the long arm of chromosome 15 (15q21.2). This gene spans a region that consists of a 30 kb coding region and a 93 kb regulatory region ( approximately 123 kb total length). Its regulatory region contains at least 10 distinct promoters regulated in a tissue- or signaling pathway-specific ...
Serdar E, Bulun, Kazuto, Takayama, Takashi, Suzuki, Hironobu, Sasano, Bertan, Yilmaz, Siby, Sebastian   +5 more
openaire   +2 more sources

CYP17 and CYP19 gene polymorphisms in women affected with endometriosis

Fertility and Sterility, 2009
To investigate whether CYP17 T>C polymorphism and polymorphisms C1558T and Val80 of CYP19 are related to endometriosis.Clinical study.Women affected with endometriosis (n = 104) and control group (n = 86). The diagnosis of endometriosis was confirmed by the histologic examination of the endometriotic lesions.In patients affected with endometriosis, we ...
VIETRI, Maria Teresa, CIOFFI, Michele, SESSA M, SIMEONE S, BONTEMPO, Paola, TRABUCCO E, ARDOVINO M, COLACURCI, Nicola, MOLINARI, Anna Maria, COBELLIS, Luigi   +9 more
openaire   +2 more sources

A Candidate Gene Study of CYP19 (Aromatase) and Male Sexual Orientation

Behavior Genetics, 2004
Aromatase cytochrome P450 (CYP19), which is necessary for the conversion of androgens to estrogens, plays an important role in the sexual differentiation of the brain. To investigate whether differences in the gene encoding the aromatase enzyme influence sexual orientation in men, we conducted linkage, association, and expression analyses in a large ...
Caroline M Nievergelt, Brian Mustanski, Dean Hamer   +2 more
exaly   +3 more sources

Aromatase activity and CYP19 gene expression in breast cancers

The Journal of Steroid Biochemistry and Molecular Biology, 1996
The aromatase enzyme complex is responsible for the conversion of C19 androgens to oestrogens. Aromatase expression in oestrogen-responsive breast cancers may be an important mechanism of autocrine regulation in tumour growth. To evaluate whether aromatase cytochrome P450 (P450arom) transcript levels within breast tumours were correlated to the enzyme ...
Sourdaine, Pascal, Mullen, Peter, White, Roger, Telford, June, Parker, Malcolm, Miller, William   +5 more
openaire   +3 more sources