Results 161 to 170 of about 2,702,703 (186)

Different promoter usage for CYP19 gene expression in buffalo ovary and placenta

General and Comparative Endocrinology, 2009
Aromatase is the key enzyme for estrogen biosynthesis and is coded by CYP19 gene. The expression of CYP19 gene is regulated in tissue-specific manner by alternate use of different promoters. In this study, we have analyzed tissue-specific expression and their regulation of CYP19 gene in preovulatory and postovulatory stages of buffalo (Bubalus bubalis)
Monika vashisht
exaly   +3 more sources

A Novel Polymorphism of the CYP19 Gene is Associated with Essential Hypertension in China

Clinical Laboratory, 2016
Aromatase which is encoded by the CYP19 gene is a key enzyme in the conversion of androgen to estrogen and plays an important role in the balance of the gender hormone levels. The gender hormone has a causal role in the development of cardiovascular disease.
Yan-zhen, Fu, Bei, Wang, Tong-yi, Ma, Ding, Huang, Fen, Liu, Lan-chun, Dong, Ting, Wang, Jie-ya, Meng   +7 more
openaire   +2 more sources

Polymorphisms in the CYP19 Gene that Influence Bone Mineral Density

Pharmacogenomics, 2007
Osteoporosis is a prevalent disease with a strong genetic component. Estrogens play a critical role in bone homeostasis. The aromatization of androgenic precursors is the main source of estrogens in men and postmenopausal women. Thus, aromatase is an attractive osteoporosis candidate gene. In this paper the influence of aromatase activity and aromatase
openaire   +2 more sources

Novel Promoter I.8 and Promoter Usage in the CYP19 (Aromatase) Gene

Reproductive Sciences, 2008
To date, 10 promoters were reported to regulate the expression of the human aromatase (CYP19) gene, giving rise to transcripts with an identical coding region but tissue-specific first exons comprising unique 5'-untranslated regions. We describe the identification and characterization of a new CYP19 exon I, designated exon I.8, in a 5'-rapid ...
Masashi, Demura, Scott, Reierstad, Joy E, Innes, Serdar E, Bulun   +3 more
openaire   +2 more sources

Phylogeny, expression and enzyme activity of zebrafish cyp19 (P450 aromatase) genes

The Journal of Steroid Biochemistry and Molecular Biology, 2001
The cyp19 encodes P450 aromatase, the enzyme catalyzing the conversion of estrogens from androgens. Estrogens affect the dimorphic, anatomical, functional and behavioral aspects of development of both males and females. In zebrafish, two cyp19 genes, cyp19a and cyp19b were found. They are expressed in ovary and brain, respectively. Expression of cyp19b
S K, Tong, E F, Chiang, P H, Hsiao, B, Chung   +3 more
openaire   +2 more sources

Association of CYP19 Gene Polymorphism with Vertebral Fractures in Japanese Postmenopausal Women

Biochemical Genetics, 2011
This study investigates aromatase gene polymorphism, which might influence bone strength in terms of mineral density and quality. We explored the relationship between CYP19 polymorphisms and vertebral fractures in postmenopausal Japanese women. In addition, we compared estrogen and testosterone levels in Japanese postmenopausal women with and without ...
Yasuko, Koudu, Tsuneko, Onouchi, Takayuki, Hosoi, Toshiyuki, Horiuchi   +3 more
openaire   +2 more sources

Polymorphisms in the CYP19 gene confer increased risk for Alzheimer disease

Neurology, 2004
Brain aromatase may be neuroprotective by increasing the local estrogen levels in injured neurons. Aromatase is encoded by the CYP19 gene located at 15q21.1, a chromosomal region in linkage disequilibrium (LD) with Alzheimer disease (AD) in this sample.To investigate whether nine single-nucleotide polymorphisms (SNP) spanning the CYP19 gene were ...
S, Iivonen, E, Corder, M, Lehtovirta, S, Helisalmi, A, Mannermaa, S, Vepsäläinen, T, Hänninen, H, Soininen, M, Hiltunen   +8 more
openaire   +2 more sources

Human aromatase (CYP19) pharmacogenomics: Gene resequencing and functional genomics

Clinical Pharmacology & Therapeutics, 2005
Background/Aims CYP19 is a key enzyme in estrogen biosynthesis. CYP19 inhibitors are used to treat breast cancer. We set out to identify and characterize genetic polymorphisms in CYP19 as a step toward pharmacogenomic studies of aromatase inhibitors.
C MA, A ADJEI, O SALAVAGGIONE, L WANG, B ECKLOFF, E WIEBEN, A ADJEI, R WEINSHILBOUM   +7 more
openaire   +1 more source

Sexual Partner Preference Requires a Functional Aromatase (Cyp19) Gene in Male Mice

Hormones and Behavior, 2002
Sexual motivation, sexual partner preference, and sexual performance represent three different aspects of sexual behavior that are critical in determining the reproductive success of a species. Although the display of sexual behavior is under strict hormonal control in both sexes, the relative roles of androgen and estrogen receptors in activating the ...
Bakker, Julie, Honda, S., Harada, N., Balthazart, Jacques   +3 more
openaire   +3 more sources

[A polymorphism study of the CYP19 gene in endometrial cancer patients].

Voprosy onkologii, 2000
A strong connection is known to exist between initiation/promotion of endometrial cancer and excess of estrogens. Therefore, participation of certain alleles of genetic polymorphisms in steroid biosynthesis or metabolism may be responsible for predisposition to the disease. The present study, comparing CYP19 (aromatase) gene polymorphism in 85 patients
L M, Bershteĭn, E N, Imianitov, E N, Suspitsyn, M Iu, Grigor'ev, E P, Sokolov, A V, Togo, K P, Khanson, T E, Poroshina, V B, Gamaiunova, D A, Vasil'ev, A Iu, Kovalevskiĭ, O N, Volkov   +11 more
openaire   +1 more source