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Monocyte-derived cells express CYP27A1 and convert vitamin D3 into its active metabolite

Biochemical and Biophysical Research Communications, 2006
CYP27A1 catalyses hydroxylations in the biosynthesis of bile acids and the bioactivation of vitamin D3. We investigated the expression of CYP27A1 in human monocytes, monocyte-derived macrophages, and dendritic cells on mRNA and protein levels as well as ...
Marina Kreutz, Michael Rehli, Joachim Hahn   +2 more
exaly   +2 more sources

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The tumor-repressing effect of CYP27A1 on renal cell carcinoma by 27-HC arising from cholesterol metabolism.

FASEB Journal, 2022
Hao Zeng
exaly  

CYP27A1 inhibits proliferation and migration of clear cell renal cell carcinoma via activation of LXRs/ABCA1

Experimental Cell Research, 2022
Wei Jiao, Zhijuan Liang, Ye Liang
exaly  

Cholestasis as a dominating symptom of patients with CYP27A1 mutations: An analysis of 17 Chinese infants

Journal of Clinical Lipidology, 2021
She Wang, Huijun Wang
exaly  

The Interaction Effect of 27-Hydroxycholesterol Metabolism Disorder and CYP27A1 Single Nucleotide Polymorphisms in Mild Cognitive Impairment: Evidence from a Case–Control Study

Molecular Nutrition and Food Research, 2023
Rong Xiao, Wenjing Feng, Huiyan Yu
exaly  

A case of cerebrotendinous xanthomatosis with brain and spinal involvement without tendon xanthomas: Identification of a novel mutation of the CYP27A1 gene

Journal of Clinical Lipidology, 2022
Konstantinos Kalafatakis, Katerina Zekiou, Christos Stenos   +2 more
exaly  

CYP27A1 inhibits bladder cancer cells proliferation by regulating cholesterol homeostasis

Cell Cycle, 2019
Guofeng Ma, Ye Liang
exaly  

Metabolism of Vitamin D by Human CYP27A1

Biochemical and Biophysical Research Communications, 2000
Toshiyuki Sakaki, Kuniyo Inouye, K Inouye   +2 more
exaly  

Expression of human CYP27A1 in for the efficient hydroxylation of cholesterol, vitamin D3 and 7-dehydrocholesterol

Journal of Biotechnology, 2016
Frank Hannemann, Rita Bernhardt, Adrian Gerber   +2 more
exaly  

Clinical and molecular diagnosis of cerebrotendinous xanthomatosis with a review of the mutations in the CYP27A1 gene

Neurological Sciences, 2006
Gian Nicola Gallus
exaly