Results 191 to 195 of about 9,202 (195)
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β‐Cryptoxanthin uptake in THP‐1 macrophages upregulates the CYP27A1 signaling pathway
Molecular Nutrition & Food Research, 2013ScopeMitochondrial sterol 27‐hydroxylase (CYP27A1), a mediator of cholesterol homeostasis, is reported to exhibit antiatherogenic properties. Many studies suggested that all‐transretinoic acid can be used to treat atherosclerosis through retinoic acid receptor (RAR)‐mediated upregulation of CYP27A1 expression.
Hongfei, Fu +7 more
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Mast cells express CYP27A1 and CYP27B1 in epithelial skin cancers and psoriasis
European Journal of Dermatology, 2015Ultraviolet (UV) radiation and the vitamin D system are involved in immunosuppression in the skin. Previous in vitro and animal studies suggest a role for mast cells in these mechanisms.To study vitamin D3 metabolizing enzymes, CYP27A1 and CYP27B1, in mast cells in epithelial skin cancers and psoriasis.Biopsies were collected from the non-lesional and ...
Kaukinen Antti +2 more
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Regulation of human CYP27A1 by estrogens and androgens in HepG2 and prostate cells
Archives of Biochemistry and Biophysics, 2007The regulation of the human CYP27A1 gene by estrogens and androgens was studied in human liver-derived HepG2 and prostate cells. Our results show that the promoter activity, enzymatic activity and mRNA levels of CYP27A1 in HepG2 cells are downregulated by estrogen in presence of ERalpha or ERbeta.
Wanjin, Tang +2 more
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CYP27A1 driven metabolic control in macrophages regulates the tumor microenvironment
Krebs ist nach wie vor eine globale Gesundheitsherausforderung und mit fast 10 Millionen Todesfällen im Jahr 2020 die zweithäufigste Todesursache weltweit. Obwohl Immuntherapien wie die Immun-Checkpoint-Blockade bei einigen Patientinnen und Patienten zu besseren Ergebnissen geführt haben, liegen die Ansprechraten bei soliden Tumoren selten über 40 ...openaire +1 more source
2P-0453 Expression of CYP27A1 and caveolin-1 enhances cholesterol efflux
Atherosclerosis Supplements, 2003D. Sviridov +5 more
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