Results 201 to 210 of about 16,133 (222)
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Detection of single nucleotide polymorphisms in CYP2B6 gene
2002Publisher Summary Studies with new antibodies of higher sensitivity and specificity have shown that CYP2B6 is expressed in the liver of most or all individuals, but at extremely different levels, ranging from nearly undetectable up to about 80 pmol/mg of microsomal protein, which corresponds to about one-fifth of the total P450 content of the liver ...
Ulrich M, Zanger +3 more
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Association of CYP2B6 G15631T polymorphism with acute leukemia susceptibility
Leukemia Research, 2009The Cytochrome P450 (CYP) enzymes constitute one of the biggest gene families and play a vital role in the metabolism of endogenous biomolecules, drugs and xenobiotics. One of the members of this family, CYP2B6, plays a very important role in metabolizing carcinogens and medications. CYP2B6G15631T gene polymorphism reduces CYP2B6 enzyme activity.
Berköz, Mehmet, YALIN, S
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A CYP2B6-humanized mouse model and its potential applications
Drug Metabolism and Pharmacokinetics, 2018CYP2B6 is a human microsomal cytochrome P450 enzyme with broad substrate selectivity. CYP2B6 is the only functional member of the human CYP2B gene subfamily, which differs from the situation in rodents, such as mouse, where multiple functional Cyp2b genes are expressed.
Lei, Li, Qing-Yu, Zhang, Xinxin, Ding
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Pharmacogenetic screening: HLA-B(*) 5701 vs. CYP2B6 G516T.
HIV medicine, 2011link_to_subscribed_fulltext
To, SWC +6 more
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Stereoselectivity in metabolism of ifosfamide by CYP3A4 and CYP2B6
Xenobiotica, 2006The aim was to identify the hepatic cytochromes P450 (CYPs) responsible for the enantioselective metabolism of ifosfamide (IFA). The 4-hydroxylation, N2- and N3-dechloroethylation of IFA enantiomers were monitored simultaneously in the same metabolic systems using GC/MS and pseudoracemate techniques.
H, Lu, J J, Wang, K K, Chan, P A, Philip
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Which CYP2B6 Variants Have Functional Consequences for Cyclophosphamide Bioactivation?
Drug Metabolism and Disposition, 2012We read with interest the recent publications by [Ariyoshi et al. (2011)][1] and [Raccor et al. (2011)][2]. The role of a number of cytochrome P450 (P450) isozymes in the 4-hydroxylation of cyclophosphamide has been debated for several years.
Nuala A, Helsby, Malcolm D, Tingle
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Role of Human CYP2B6 in S-Mephobarbital N-Demethylation
Drug Metabolism and Disposition, 1999The role of cytochrome P-450s (CYPs) in S-mephobarbital N-demethylation was investigated by using human liver microsomes and cDNA-expressed CYPs. Among the 10 cDNA-expressed CYPs studied (CYP1A1, CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CYP3A4), only CYP2B6 could catalyze S-mephobarbital N-demethylation.
K, Kobayashi +6 more
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CYP2B6 Genotype Alters Abstinence Rates in a Bupropion Smoking Cessation Trial
Biological Psychiatry, 2007Larry W Hawk +2 more
exaly
Human hepatic CYP2B6 developmental expression: The impact of age and genotype
Biochemical Pharmacology, 2009Ronald N Hines
exaly