Results 101 to 110 of about 45,621 (284)

Clinical considerations in transitioning patients with epilepsy from clonazepam to clobazam: a case series. [PDF]

, 2014
IntroductionIn treating refractory epilepsy, many clinicians are interested in methods used to transition patients receiving clonazepam to clobazam to maintain or increase seizure control, improve tolerability of patients' overall drug therapy regimens ...
Chung, Steve, Kuzniecky, Ruben, Perry, Michael Scott, Sankar, Raman, Sinha, Saurabh   +4 more
core   +1 more source

Integrated Anatomical, Chemical, Biological and Computational Studies Approach of Myrcia sylvatica (G. Mey) DC. A Multifaceted Insight Into a Promising Amazonian Species

Flavour and Fragrance Journal, EarlyView.
This study presents an integrated anatomical, chemical, biological, and computational analysis of Myrcia sylvatica, revealing key bioactive compounds with antioxidant and toxicological potential, and identifying spathulenol and globulol as promising acetylcholinesterase inhibitors with favourable pharmacokinetic properties. ABSTRACT Myrcia sylvatica (G.
Eliza de Jesus Barros dos Santos, Zelina Ataíde Correia, Ely Simone Cajueiro Gurgel, Leonardo Souza da Costa, Mabrouk Horchani, Hayet Edziri, Ravendra Kumar, Anderson de Santana Botelho, Karyme do Socorro de Souza Vilhena, Eloisa Helena de Aguiar Andrade, Mozaniel Santana de Oliveira   +10 more
wiley   +1 more source

Importância prognóstica do alelo CYP2C19*2 após uma síndrome coronária aguda: dados de um centro nacional [PDF]

, 2012
BACKGROUND: Clopidogrel requires oxidation dependent on the cytochrome P450 enzyme 2C19 (CYP2C19) to form its active metabolite. The importance of loss-of-function alleles (particularly CYP2C19*2, 681G>A) in poor platelet response to clopidogrel is well ...
Ferreira, MJ, Freitas, M, Gonçalves, F, Lourenço, M, Marques, G, Monteiro, P, Monteiro, S, Pego, J, Providência, LA, Reboredo, A, Ribeiro, G, Tavares, C, Teixeira, R   +12 more
core  

CYP2C9 and CYP2C19: Deep Mutational Scanning and Functional Characterization of Genomic Missense Variants

Clinical and Translational Science, 2020
Single nucleotide variants in the open reading frames (ORFs) of pharmacogenes are important causes of interindividual variability in drug response. The functional characterization of variants of unknown significance within ORFs remains a major challenge ...
Lingxin Zhang, V. Sarangi, Irene Moon, Jia Yu, Duan Liu, Sandhya Devarajan, J. Reid, K. Kalari, Liewei Wang, R. Weinshilboum   +9 more
semanticscholar   +1 more source

Impact of CYP2C19 Genotype Variants on PCSK9 Inhibitor Efficacy in Lipid‐Lowering Among Patients With Symptomatic Intracranial Atherosclerotic Stenosis

Lipids, EarlyView.
ABSTRACT Ischemic stroke is frequently associated with symptomatic intracranial atherosclerotic stenosis (sICAS), is a leading cause of global disability and mortality. Current guidelines recommend dual antiplatelet and intensive statin therapies. Proprotein convertase subtilisin 9/kexin type 9 (PCSK9) inhibitors have emerged as a potent lipid‐lowering
Chao Zhao, Nuan Wang, Di Shi, Hao Zhou, Dan Chen, Guofang Chen   +5 more
wiley   +1 more source

Investigating Real-World Clopidogrel Pharmacogenetics in Stroke Using a Bioresource Linked to Electronic Medical Records [PDF]

, 2017
Clopidogrel efficacy is influenced by genetic variation of CYP2C19, however few studies have considered stroke patients. We used electronic medical records (EMR) linked to a bioresource to examine real-world implications of clopidogrel pharmacogenetics ...
Doney, Alex S. F., Flynn, Rob, MacDonald, Thomas M., Morant, Steve, Palmer, Colin N. A., Tornio, Aleksi, Velten, Elena   +6 more
core   +2 more sources

ASSESSMENT OF THE CLOPIDOGREL ACTION WITH REGARD TO CYP2C19 GENE POLYMORPHISMS IN PATIENTS WITH CORONARY ARTERY DISEASE AFTER IMPLANTATION OF DES STENTS

Евразийский Кардиологический Журнал, 2019
Aim of the work to assess the impact of CYP2C19 polymorphisms, including those of CYP2C19*1, CYP2C19*2, CYP2C19*3 and CYP2C19*17 on clopidogrel response variability in patients undergoing percutaneous coronary intervention (PCI) following DES ...
J. K. Uzokov, B. A. Alyavi, A. X. Abdullaev   +2 more
doaj  

A novel AllGlo probe-quantitative PCR method for detecting single nucleotide polymorphism in CYP2C19 to evaluate the antiplatelet activity of clopidogrel

Scientific Reports
CYP2C19 gene has multiple single nucleotide polymorphism (SNP), which is the major determinant for clopidogrel treatment responses. Therefore, CYP2C19 SNP detection is essential for predicting clopidogrel efficacy.
Hongwei Li, Yizhen Fang, Yongquan Chen, Yuning Lin, Zanxi Fang, Zhiyuan Lin, Huabin Xie, Zhongying Zhang   +7 more
doaj   +1 more source

Both CYP2C19 and PON1 Q192R Genotypes Influence Platelet Response to Clopidogrel by Thrombelastography in Patients with Acute Coronary Syndrome

Cardiovascular Therapeutics, 2019
Objective. The objective of this study is to explore the relationships of the effects of CYP2C19 and PON1 Q192R polymorphism on the activity of clopidogrel and the risk of high platelet responsiveness (HPR) by thrombelastography in patients with acute ...
Wenxing Peng, Xiujin Shi, Xiaoyu Xu, Yang Lin   +3 more
doaj   +1 more source

In vitro inhibitory effect of lysionotin on the activity of cytochrome P450 enzymes

Pharmaceutical Biology, 2020
Context Lysionotin, a major extraction of Lysionotus pauciflorus Maxim (Gesneriaceae), has a variety of pharmacological properties commonly used in the treatment of lung disease.
Yang Li, Jing Qin, Hong Wu, Yongmei Xu, Li Zhang, Keren Su, Ying Cui, Haiping Wang   +7 more
doaj   +1 more source