Results 121 to 130 of about 36,503 (286)

Both CYP2C19 and PON1 Q192R Genotypes Influence Platelet Response to Clopidogrel by Thrombelastography in Patients with Acute Coronary Syndrome

Cardiovascular Therapeutics, 2019
Objective. The objective of this study is to explore the relationships of the effects of CYP2C19 and PON1 Q192R polymorphism on the activity of clopidogrel and the risk of high platelet responsiveness (HPR) by thrombelastography in patients with acute ...
Wenxing Peng, Xiujin Shi, Xiaoyu Xu, Yang Lin   +3 more
doaj   +1 more source

Gene variants with suicidal risk in a sample of subjects with chronic migraine and affective temperamental dysregulation [PDF]

, 2012
BACKGROUND: Risk factors for suicide are at least partially heritable and functional polymorphisms of targeted genes have been suggested to be implicated in the pathogenesis of this phenomenon.
BORRO, Marina, D. A. Lamis, GENTILE, Giovanna, GIRARDI, Paolo, LALA, NOEMI, M. Innamorati, MARTELLETTI, Paolo, NEGRO, ANDREA, POMPILI, Maurizio, SERAFINI, Gianluca, SIMMACO, Maurizio   +10 more
core  

CYP2C19 and CYP2C9 geno- and phenotypes in healthy Swedish and Korean subjects [PDF]

, 2011
Cytochrome P450s (CYPs) are responsible for approximately 75% of the phase Idependent drug metabolism. Several important polymorphisms in these enzymes are known to affect the individual drug response.
Ramsjö, Margareta
core   +1 more source

Development and Verification of Virtual Population Models for Predicting Drug Pharmacokinetics in Ethnic North American Populations

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Ethnic variabilities can affect the outcome of drug pharmacokinetics (PK) and drug–drug interactions (DDI). This work aimed to develop four North American (NA) sub‐populations: White, African American, Asian American, and Hispanic_Latino suitable for physiologically based pharmacokinetic (PBPK) modeling and simulations.
Udoamaka Ezuruike, Jean Dinh, Eman El‐Khateeb, Alex Blenkinsop, Oliver Hatley, Iain Gardner   +5 more
wiley   +1 more source

Polymorphisms in genes involved in the absorption, distribution, metabolism, and excretion of drugs in the Kazakhs of Kazakhstan [PDF]

, 2016
A list of SNPs that were not found in heterozygous or homozygous variants.
Aisha N. Iskakova, Akbota M. Aitkulova, Aliya A. Romanova, Elena V. Zholdybayeva, Erlan M. Ramanculov, Nurgul S. Sikhayeva   +5 more
core   +5 more sources

CYP2C19 and CYP2D6 genotypes in Pacific peoples [PDF]

British Journal of Clinical Pharmacology, 2016
The study of pharmacogenetic variants in populations which reside in Oceania has been focused mainly on CYP2C19 and CYP2D6. Statements about the high prevalence of CYP2C19 no function genotype in ‘Pacific Islanders’ can be found in the literature. This review article summarizes the published information about these pharmacogenes in this geographical ...
openaire   +3 more sources

Efficacy and Safety of Vonoprazan and High‐Dose Amoxicillin Dual Therapy for Rescue Treatment of Helicobacter pylori Infection: A Multicenter Randomized Controlled Trial

United European Gastroenterology Journal, EarlyView.
ABSTRACT Background Vonoprazan and amoxicillin dual therapy has demonstrated favorable efficacy in the initial treatment of Helicobacter pylori (H. pylori) infection. This study aimed to evaluate the efficacy and safety of vonoprazan and high‐dose amoxicillin (VHA) dual therapy for H. pylori rescue treatment. Methods This was an open label, multicenter,
Ju Zhang, Xinzhao Wang, Shujie Song, Xiaoming Zhu, Ting Lv, Lingling Wang, Lei Lei, Yuhui Wang, Yali Lei, Yating Wang, Xiaojing Zhu, Lifeng Zhang, Min Chen, Yongquan Shi   +13 more
wiley   +1 more source

Eletriptan in the management of acute migraine. An update on the evidence for efficacy, safety, and consistent response [PDF]

, 2016
Migraine is a multifactorial, neurological and disabling disorder, also characterized by several autonomic symptoms. Triptans, selective serotonin 5-HT1B/1D agonists, are the first-line treatment option for moderate-to-severe headache attacks.
Capi, Matilde, Curto, Martina, De Andrés, Fernando, Gentile, Giovanna, Lionetto, Luana, Martelletti, Paolo, Negro, Andrea   +6 more
core   +1 more source

Defining Treatment‐Resistant Bipolar Depression: Recommendations From the ISBD Task Force

Bipolar Disorders, EarlyView.
ABSTRACT Objective Despite the availability of approved treatments, a substantial proportion of patients with bipolar disorder experience treatment‐resistant bipolar depression (TRBD), characterized by persistent depressive symptoms unresponsive to standard therapies. However, a universally accepted definition of TRBD is lacking.
Eduard Vieta, Roger S. McIntyre, Trisha Suppes, Tamsyn E. Van Rheenen, Balwinder Singh, Kamilla Woznica Miskowiak, Allan H. Young, Lakshmi N. Yatham, Kyooseob Ha, Michael Berk, Holly A. Swartz, Chantal Henry, Maja Pantovic Stefanovic, Gerard Anmella Diaz, Aysegul Ozerdem, Wiesław J. Cubała, Diego Hidalgo‐Mazzei, Mauricio Tohen, Isabella Pacchiarotti, Paula Villela Nunes, Carlos Lopez‐Jaramillo, Ana Gonzalez‐Pinto, Paolo Brambilla, Robert Post, Jair C. Soares, Michael Bauer, Ana C. Andreazza, Xavier Justes Fradera, Montserrat Cosials‐Lopez, Giovanna Fico   +29 more
wiley   +1 more source

Status epilepticus in older adults: A critical review

Epilepsia, EarlyView.
Abstract Older adults (≥60 years of age) have the highest incidence of status epilepticus (SE) among adults and experience the highest morbidity and mortality. SE incidence increases with age in adulthood. A recent study from Austria estimated an incidence of 89.6/100 000 and 67.6/100 000 person‐years adjusted for age and sex in women and men aged >60 ...
Matthew R. Woodward, Michael J. Armahizer, Tina I. Wang, Neeraj Badjatia, Emily L. Johnson, Emily J. Gilmore   +5 more
wiley   +1 more source