Results 131 to 140 of about 45,621 (284)

PERSONALIZED APPROACH TO TREATMENT OF CHRONIC INFLAMMATORY DISEASES OF THE UPPER GASTROINTESTINAL TRACT IN CHILDREN WITH CYP2C19 POLYMORPHISM ACCOUNT

Медицинский вестник Юга России, 2015
Purpose: the personification approach to the choice of antisecretory drugs in chronic gastroduodenitis, gastroesophagealreflux disease in children.Materials and methods: The study involved 70 children (12-14 years) with chronic inflammatory diseases of ...
E. V. Dudnikova, N. U. Azievа, A. S. Badian, M. S. Chernova, L. D. Azievа   +4 more
doaj   +1 more source

Strategy for Identifying Rational Sensitivity Analysis Using PBPK Modeling for Precipitant Drug–Drug Interaction Predictions

Clinical Pharmacology &Therapeutics, Volume 119, Issue 2, Page 314-317, February 2026.
Physiology Based Pharmacokinetic (PBPK) modeling is an established essential tool for predicting and/or analyzing drug–drug interactions (DDI). Uncertainty and variability associated with in vitro determined DDI‐related parameters have often been considered a limitation for predicting PBPK‐DDIs.
Kunal S. Taskar, Pradeep Sharma, Karen Rowland Yeo   +2 more
wiley   +1 more source

Acute and long-term effects of brivaracetam and brivaracetam-diazepam combinations in an experimental model of status epilepticus. [PDF]

, 2017
ObjectiveTo evaluate acute and long-term effects of intravenous brivaracetam (BRV) and BRV + diazepam (DZP) combination treatment in a rat model of self-sustaining status epilepticus (SSSE).MethodsRats were treated with BRV (10 mg/kg) 10 min after ...
Alldredge, Biton, Brophy, Chen, Coeytaux, DeLorenzo, FDA, Gezalian, Gillard, Glauser, Griffin, Klein, Klein, Klein, Klitgaard, Klitgaard, Matagne, Matagne, Mazarati, Mazarati, Mazarati, Naylor, Nicolas, Reagan-Shaw, Ryvlin, Sanchez, Silbergleit, Stockis, Suchomelova, Treiman, Trinka, Wasterlain, Wood   +32 more
core   +1 more source

Gut Microbial Variations Associated With Proton Pump Inhibitor Use in the Boston Puerto Rican Health Study

Pharmacology Research &Perspectives, Volume 14, Issue 1, February 2026.
ABSTRACT Proton pump inhibitors (PPI), used to treat gastrointestinal disorders, are associated with alterations in the gut microbiome. However, this is understudied in Puerto Ricans who have unique lifestyle characteristics. Puerto Ricans, including participants of the Boston‐Puerto Rican Health Study (BPRHS), report high PPI use.
Deepika Dinesh, Xochitl C. Morgan, Hanseul Kim, Tammy M. Scott, Mahdi Garelnabi, Jong Soo Lee, Kelsey M. Mangano, Long H. Nguyen, Curtis Huttenhower, Katherine L. Tucker, Natalia Palacios   +10 more
wiley   +1 more source

Polymorphic drug metabolising enzymes:Assessment of activities by phenotyping and genotyping in clinical pharmacology [PDF]

, 2001
Drug effects (pharmacodynamics) are determined by drug concentration at target site and the affinity of the drug for a target. Pharmacogenetics describes inherited differences in drug metabolising enzyme activities and differences in drug transporters ...
Tamminga, Willem Jan
core   +2 more sources

CYP3A and CYP2C19 activity in urine in relation to CYP3A4, CYP3A5, and CYP2C19 polymorphisms in Russian peptic ulcer patients taking omeprazole

Pharmacogenomics and Personalized Medicine, 2018
Natalia P Denisenko,1–3 Dmitriy A Sychev,2 Zhanna M Sizova,3 Valeriy V Smirnov,4,5 Kristina A Ryzhikova,1 Zhannet A Sozaeva,1 Elena A Grishina1 1Research Center, Russian Medical Academy of Continuous Professional Education, Ministry of Healthcare ...
Denisenko NP, Sychev DA, Sizova ZM, Smirnov VV, Ryzhikova KA, Sozaeva ZA, Grishina EA   +6 more
doaj  

Efavirenz and CYP2C9 Genetic Polymorphisms Reduce CYP2C9 Activity in Healthy Participants

Clinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT Efavirenz's effects on cytochrome P450 2C9 (CYP2C9) activity have not been formally characterized in vivo. We conducted the first clinical drug–drug interaction (DDI) study to test the effect of chronic efavirenz dosing on CYP2C9 activity, using tolbutamide as a selective probe.
Jason D. Kim, Ingrid F. Metzger, Jessica Bo Li Lu, Todd C. Skaar, Zeruesenay Desta   +4 more
wiley   +1 more source

Platelet Function Testing in Patients with Acute Ischemic Stroke: An Observational Study [PDF]

, 2017
Background: The measurement of platelet reactivity in patients with stroke undergoing antiplatelet therapies is not commonly performed in clinical practice.
Bigliardi, Guido, Dell'Acqua, Maria Luisa, FERRARO, Diana, Lelli, Nicoletta, Mimmi, Stefano, NICHELLI, Paolo Frigio, Pentore, Roberta, Picchetto, Livio, Rosafio, Francesca, Trenti, Tommaso, Vandelli, Laura, Zini, Andrea   +11 more
core   +1 more source

Acanthospermum hispidum and Its Metabolite Stigmasterol Modulates Anti‐Inflammatory Antagonism of COX‐1 and TGF‐β

Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.
This study evaluates the anti‐inflammatory effect of Acanthospermum hispidum (AH) leaves and confirms its traditional use on diseases linked to inflammation. AH ethanol extract presents a dose‐dependent increase in anti‐inflammatory activity on the different times examined (T30 – T150). Also, stigmasterol present in AH shows potent antagonist influence
Onome Mary Adeboye, Abimbola Sowemimo, Muyiwa Samuel Fageyinbo, Oluwasegun Adedokun, Abdul Basit, Opeyemi Joshua Olatunji, Epole Ngolle Ntungwe   +6 more
wiley   +1 more source

Carboplatin/taxane-induced gastrointestinal toxicity: a pharmacogenomics study on the SCOTROC1 trial [PDF]

, 2016
Carboplatin/taxane combination is first-line therapy for ovarian cancer. However, patients can encounter treatment delays, impaired quality of life, even death because of chemotherapy-induced gastrointestinal (GI) toxicity.
Brown, R., Glass, S., He, Y.J., Hoskins, J.M., McLeod, H.L., Motsinger-Reif, A., Paul, J., Winham, S.J.   +7 more
core   +1 more source