Results 131 to 140 of about 36,503 (286)

CYP2C19 genotype status and intragastric pH during dosing with lansoprazole or rabeprazole [PDF]

open access: bronze, 2000
Kyoichi Adachi   +9 more
openalex   +1 more source

Development and Validation of a Rapid LC–MS/MS Method for Plasma Analysis of Ketamine, Norketamine, Dehydronorketamine, and Hydroxynorketamine

open access: yesBiomedical Chromatography, Volume 39, Issue 9, September 2025.
ABSTRACT Ketamine, a well‐established dissociative anesthetic, has recently gained significant attention for its rapid‐acting antidepressant effects, particularly in treatment‐resistant depression. In this study, we developed and validated a state‐of‐the‐art liquid chromatography–tandem mass spectrometry (LC–MS/MS) method for the bioanalysis of ...
Jan Thomann   +5 more
wiley   +1 more source

Pyriproxyfen Disrupts the Ongoing Spermatogenesis Wave in Danio rerio Potentially Mediated by Voltage‐Dependent Calcium Channels and Protein Kinase C

open access: yesJournal of Applied Toxicology, Volume 45, Issue 9, Page 1705-1719, September 2025.
ABSTRACT Pyriproxyfen (PPX) is an analog of the juvenile hormone from insects. Following our previous studies, for the ex vivo short‐term effect, we chose 10−9 M pyriproxyfen to analyze the morphology of spermatogenesis wave cells. In silico docking and ADMET (Absorption, Distribution, Metabolism, Excretion, Toxicity) studies were carried out to ...
Bruna Antunes Zaniboni   +5 more
wiley   +1 more source

Effect of co-administered inducer or inhibitor on omeprazole pharmacokinetics based on CYP2C19 genotype

open access: yesJournal of Pharmacological Sciences, 2019
Polymorphisms of cytochrome P450 (CYP) enzymes can affect enzymatic activity, drug metabolism and drug interactions. Although the potential for drug interactions is especially important when co-administering drugs with strong inductive or inhibitory ...
Chiaki Kamiya   +8 more
doaj  

Omega-3 Polyunsaturated Fatty Acids in Treatment of Patients with Coronary Heart Disease and Type 2 Diabetes Mellitus [PDF]

open access: yes, 2012
Increased platelet aggregation is one of the major risk factors for cardiovascular events. However, recent studies have demonstrated the inhibition of platelet aggregation by omega-3 PUFAs.
Aisulu T. Mussagalieva, MD, PhD   +1 more
core  

Opportunities and Challenges of Population Pharmacogenomics

open access: yesAnnals of Human Genetics, Volume 89, Issue 5, Page 384-397, September 2025.
ABSTRACT Pharmacological responses can vary significantly among patients from different ethnogeographic backgrounds. This variability can, at least in part, be attributed to population‐specific genetic patterns in genes involved in drug absorption, distribution, metabolism, and excretion, as well as in genes associated with drug‐induced toxicity ...
Yitian Zhou   +3 more
wiley   +1 more source

Embedding Pharmacogenetics Into Clinical Practice to Improve Patient Outcomes

open access: yesAnnals of Human Genetics, Volume 89, Issue 5, Page 398-405, September 2025.
ABSTRACT Pharmacogenomics, the use of germline genomic data to guide prescription to improve effective and safer medication, holds promise as a clinical intervention. To date in most health systems, there has been limited uptake of pharmacogenomic testing confined to a few single drug–gene associations.
John Henry McDermott   +3 more
wiley   +1 more source

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