Results 131 to 140 of about 36,503 (286)
CYP2C19 genotype status and intragastric pH during dosing with lansoprazole or rabeprazole [PDF]
Kyoichi Adachi+9 more
openalex +1 more source
ABSTRACT Ketamine, a well‐established dissociative anesthetic, has recently gained significant attention for its rapid‐acting antidepressant effects, particularly in treatment‐resistant depression. In this study, we developed and validated a state‐of‐the‐art liquid chromatography–tandem mass spectrometry (LC–MS/MS) method for the bioanalysis of ...
Jan Thomann+5 more
wiley +1 more source
CYP2C19*2 polimorfismo y resistencia a clopidogrel [PDF]
Viroj Wiwanitkit, Beuy Joob
openaire +4 more sources
ABSTRACT Pyriproxyfen (PPX) is an analog of the juvenile hormone from insects. Following our previous studies, for the ex vivo short‐term effect, we chose 10−9 M pyriproxyfen to analyze the morphology of spermatogenesis wave cells. In silico docking and ADMET (Absorption, Distribution, Metabolism, Excretion, Toxicity) studies were carried out to ...
Bruna Antunes Zaniboni+5 more
wiley +1 more source
Polymorphisms of cytochrome P450 (CYP) enzymes can affect enzymatic activity, drug metabolism and drug interactions. Although the potential for drug interactions is especially important when co-administering drugs with strong inductive or inhibitory ...
Chiaki Kamiya+8 more
doaj
Omeprazole and CYP2C19 polymorphism: effects of long‐term treatment on gastrin, pepsinogen I, and chromogranin A in patients with acid related disorders [PDF]
M. Sagar+5 more
openalex +1 more source
Omega-3 Polyunsaturated Fatty Acids in Treatment of Patients with Coronary Heart Disease and Type 2 Diabetes Mellitus [PDF]
Increased platelet aggregation is one of the major risk factors for cardiovascular events. However, recent studies have demonstrated the inhibition of platelet aggregation by omega-3 PUFAs.
Aisulu T. Mussagalieva, MD, PhD+1 more
core
CYP2D6 and CYP2C19 genotypes of patients with terodiline cardiotoxicity identified through the yellow card system [PDF]
Gary A. Ford, Susan M. Wood, Ann K. Daly
openalex +1 more source
Opportunities and Challenges of Population Pharmacogenomics
ABSTRACT Pharmacological responses can vary significantly among patients from different ethnogeographic backgrounds. This variability can, at least in part, be attributed to population‐specific genetic patterns in genes involved in drug absorption, distribution, metabolism, and excretion, as well as in genes associated with drug‐induced toxicity ...
Yitian Zhou+3 more
wiley +1 more source
Embedding Pharmacogenetics Into Clinical Practice to Improve Patient Outcomes
ABSTRACT Pharmacogenomics, the use of germline genomic data to guide prescription to improve effective and safer medication, holds promise as a clinical intervention. To date in most health systems, there has been limited uptake of pharmacogenomic testing confined to a few single drug–gene associations.
John Henry McDermott+3 more
wiley +1 more source