Results 141 to 150 of about 10,726 (197)

Physiologically Based Pharmacokinetic Model of Brigatinib in Healthy Volunteers and Patients With Cancer. [PDF]

CPT Pharmacometrics Syst Pharmacol
Xu Y, Hu X, Zhao P, Wang L, Ruan Z, Jiang B, Lou H.   +6 more
europepmc   +1 more source

Comparative analysis of sex-based, vendor-based, and species differences in cytochrome P450 metabolism. [PDF]

Sci Rep
Kinatukara N, Xu X, Shah P.
europepmc   +1 more source

Safety, tolerability, pharmacokinetics, and pharmacodynamics of zapnometinib: results from a phase I clinical study. [PDF]

Front Pharmacol
Stenglein S, Volk J, Füll Y, Reh C, Haffner S, Canisius S, Overend T, Planz O.   +7 more
europepmc   +1 more source

Pharmacokinetics, distribution, metabolism, excretion and safety characterization of ZJCK-6-72: novel DYRK1A inhibitor with optimized brain exposure for Alzheimer's disease therapy. [PDF]

Front Pharmacol
Li Z, Chen H, Li X, Yang A, Wang X, Liu S, Ning X, Zhou L, Zheng F, Xun F, Hu B, Cui Y, Yao D, Gao X, Xu Z, Zhao Q.   +15 more
europepmc   +1 more source

Development of an isavuconazole physiologically-based pharmacokinetic model for adult and pediatric populations. [PDF]

J Pharmacokinet Pharmacodyn
Choules MP, Desai A, Kovanda LL, Otsuka Y, Brüggemann RJ, Bonate PL.   +5 more
europepmc   +1 more source

Improving hepatic metabolic function with 3D iPSC-derived human hepatocytes. [PDF]

Cell Biol Toxicol
Pozo Garcia V, Kiamehr M, Versteegden R, Naderlinger E, Jennings P, Verfaillie C, Vos JC, Moco S.   +7 more
europepmc   +1 more source

Prediction of Biomarkers for Hepatocellular Carcinoma Based on Proteomics and Phosphoproteomics. [PDF]

Int J Gen Med
Sun X, Huang H, Zhang Q, Cao X, Zhang D, Wang X, Lu X, Pu C.   +7 more
europepmc   +1 more source

Assessing ADME gene coverage: An observational study on chloroquine therapy for COVID-19. [PDF]

Medicine (Baltimore)
Zaid N, Benchikhi L, El Abboudi N, Khalki L, Badad O, Limami Y, Naya A, Oudghiri M, Himmi B, Zaid Y.   +9 more
europepmc   +1 more source

Simulation of Imatinib Pharmacokinetics in pregnant women with chronic myeloid leukemia in the third trimester. [PDF]

Eur J Clin Pharmacol
Mian P, Lok CAR, Dontje AEWK, Prins JR, Oude Munnink TH, Nieuwenhuizen L, Gordijn SJ, Touw DJ, Malik P.   +8 more
europepmc   +1 more source

Unraveling enantioselective metabolism: Human cytochrome P450s in arachidonic acid biotransformation. [PDF]

Drug Metab Dispos
Isse FA, El-Sherbeni AA, El-Kadi AOS.
europepmc   +1 more source