Results 111 to 120 of about 35,596 (239)

Current Status of Research on Losartan in Tumour Therapy

Journal of Cellular and Molecular Medicine, Volume 30, Issue 1, January 2026.
ABSTRACT Losartan, a widely prescribed antihypertensive agent, has attracted growing interest as a potential adjuvant in cancer therapy due to its affordability, established safety profile and pleiotropic effects. Emerging preclinical evidence demonstrates that losartan can effectively modulate the tumour microenvironment (TME) by inhibiting ...
Han Wang, Shuang Yuan, Hongjing Wang
wiley   +1 more source

The Frequency of CYP2C9 and VKORC1 Gene Polymorphic Alleles in Georgian Population

, 2016
D Mozaffarian, J Menon, M Salman, G Md, S Khan, J Dickerman, A Rettie, G Tai, Nada Boina, Schwarz Ui, M Ritchie, T Moyer, O' Kane, D Baudhuin, L, I Jukic, J Saour, A Shereen, B Saour, L Mammo, M Wadelius, M Pirmohamed, S Sanderson, J Emery, J Higgins, L Cavallari, T Langaee, K Momary, N Shapiro, E Nutescu, W Coty, M Shahin, S Kimmel   +32 more
openalex   +1 more source

CYP2C9 Pharmacogenomics: Recent Update and Clinical Relevance [PDF]

, 2006
Su‐Jun Lee, Jae‐Gook Shin
openalex   +1 more source

CYP2C9 Inducer [PDF]

, 2020
openaire   +1 more source

Pharmacovigilance‐Based Identification and Mechanistic Exploration of Periodontitis‐Related Drugs

Journal of Clinical Periodontology, Volume 53, Issue 1, Page 117-126, January 2026.
ABSTRACT Background Periodontitis is a common chronic inflammatory disease. However, drug‐related risks and underlying molecular mechanisms remain underexplored from large real‐world data. Methods We first mined the US Food and Drug Administration Adverse Event Reporting System (FAERS) database to identify drugs disproportionately associated with ...
Wuda Huoshen, Junkai Xiong, Xunmi Ma, Heng Wang, Panyu Cheng, Xinyu Chen, Ge Shuai, Yi Chen, Xinyue Zhang, Chen Sun, Chunhui Li, Rui Shi   +11 more
wiley   +1 more source

Quantitative Treatments for Explaining the Mechanism and Kinetics of Catalytic Electron Transfers in Murburn Processes, Particularly Involving Heme Enzymes Like (Per)oxidases and P450s

BioMed Research International, Volume 2026, Issue 1, 2026.
The seminal Michaelis–Menten theorization for biological catalysis was based on “transition state” (TS), involving the formation of a topologically complementary substrate (S) and enzyme (E) complex (ES) at the “active site” of the latter. Rudolph Marcus put forth the theory of outer sphere electron transfer (ET) in a “donor–acceptor” TS complex, which
Kelath Murali Manoj, Daniel Andrew Gideon, Philip Moses Samuel, Suhotra Das, Nahit Gencer   +4 more
wiley   +1 more source

Effect of CYP2C9 gene polymorphisms on response to treatment with sulfonylureas in a cohort of Egyptian type 2 diabetes mellitus patients [PDF]

, 2012
Randa Salam, Reham Zeyada, Noha A. Osman
openalex   +1 more source

Association of Breast Cancer with Single Nucleotide Polymorphism of CYP2C9 Gene for Women Patients in Baghdad, Iraq

, 2023
Mohammed R. Al-Lami, Falah S. Al-Fartusie, Dheaa SH. Zageer   +2 more
openalex   +2 more sources

In Vitro Evaluation and Network Pharmacology Analysis of the Antimicrobial Activity of Pistacia lentiscus

International Journal of Dentistry, Volume 2026, Issue 1, 2026.
Background Chios mastic gum, a natural resin derived from the mastic tree, has a history of traditional use for its beneficial effects on the gastrointestinal system, its anti‐inflammatory properties, and its antimicrobial activity. Objective This study aimed to integrate network pharmacology and standardized in vitro analyses to elucidate the ...
Aparna Ganeshkumar, Ram Sabarish, Nadha Shakir, Divya Shree Sankar, Adelyn Jerusha Franklin, Nagalakshmi Gandhi, Kennedy Kumar, Amjad Abu Hasna   +7 more
wiley   +1 more source

Single‐Cell RNA‐seq Reveals Deubiquitination Genes as Prognostic Markers in Hepatocellular Carcinoma

International Journal of Genomics, Volume 2026, Issue 1, 2026.
Background Hepatocellular carcinoma (HCC) carries a dismal prognosis, yet the contribution of deubiquitination—an essential posttranslational regulator—to its progression remains poorly defined. Methods Single‐cell RNA‐seq profiles of 13 treatment‐naïve HCC tumors were integrated with 374 TCGA and 243 ICGC bulk RNA‐seq cohorts.
Xuening Lv, Chaozhou Chen, Shuxian Zhang, Feng Liang, Qing Zhang, Irfan Ahmad   +5 more
wiley   +1 more source