Results 141 to 150 of about 25,089 (208)

A SHAP‐Informed Formal Feature Attribution Framework for Drug–Drug Interaction Risk in Large‐Scale Claims Data

Clinical and Translational Science, Volume 19, Issue 9, September 2026.
ABSTRACT Pairwise drug–drug interaction databases flag co‐prescribed pairs, but they under‐weight multi‐drug combinations that drive adverse drug events in older adults. We studied that gap in Virginia All‐Payer Claims Database records (2016–2019) for adults aged 65–114 years with non‐opioid emergency department visits (n = 1182 cases; 16,105 matched ...
R. Jerome Dixon, Elvin T. Price
wiley   +1 more source

Rifampin-induced fluvastatin toxicity: a case report and review of literature. [PDF]

Oxf Med Case Reports
Farghali A, Mahmoud H, Salem M.
europepmc   +1 more source

Xanomeline and Trospium Chloride: Mechanism of Action, Clinical, and Translational Science

Clinical and Translational Science, Volume 19, Issue 9, September 2026.
ABSTRACT Xanomeline‐trospium chloride (Cobenfy, formerly KarXT) is a first‐in‐class, oral central M1/M4 muscarinic receptor agonist approved for the treatment of schizophrenia in adults. Cobenfy represents a paradigm shift by avoiding direct dopamine D2 receptor blockade and thus significantly reduces the burden of metabolic, extrapyramidal, and ...
Samantha Avila, Ingrid L. Chen
wiley   +1 more source

The association of ABCB1, CYP2C19 and CYP2C9 combined activity with clopidogrel resistance in patients with recurrent ischemic stroke. [PDF]

Pharmacogenomics J
Deiman B, Hermans M, de Rijk M, Bras A, Scharnhorst V.   +4 more
europepmc   +1 more source

Treatment Goals for Primary Biliary Cholangitis, an Australian Perspective

Journal of Gastroenterology and Hepatology, Volume 41, Issue 9, Page 2623-2638, September 2026.
ABSTRACT Primary biliary cholangitis (PBC) is an autoimmune liver disease that targets the small intrahepatic bile ducts with diagnosis based on elevated serum alkaline phosphatase (ALP) levels and the presence of anti‐mitochondrial antibodies. Untreated, it may run a progressive course to cirrhosis and hepatic decompensation, at which point liver ...
Simone I. Strasser, Alexander J. Thompson, Rohit Gupta, John Lubel, Janine French, Beverly Sacks, Martin Weltman   +6 more
wiley   +1 more source

Topliss‐Guided Optimization of Acetanilide‐Based Soluble Epoxide Hydrolase Inhibitors: Exploring the Pentafluorosulfanyl Group as a Potency‐Enhancing Motif

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
Can an amide analog retain the high potency of the classic urea motif in soluble epoxide hydrolase inhibitors? Through a single unconventional switch, the introduction of the underexplored pentafluorosulfanyl group into an amide analog of TPPU, the authors restored high inhibitory potency.
Alba López‐Ruiz, Eugènia Pujol, Cristian Ramos, Valeria Rizzo, Christophe Morisseau, Cristina Val, Tiziana Ginex, Javier Vázquez, Sandra Codony, Andreea L. Turcu, Belén Pérez, Elena Sáez, Antonio Pineda‐Lucena, Bruce D. Hammock, F. Javier Luque, M. Isabel Loza, José Brea, Santiago Vázquez   +17 more
wiley   +1 more source

Cost-Effectiveness of Pharmacogenomics-Guided Treatment in Cardiovascular Disease: An Umbrella Review. [PDF]

Pharmgenomics Pers Med
Janković SM, Milosavljević M, Stević I, Ašić A, Jusić A, Devaux Y, Belančić A, Bektay MY, Pejčić AV.   +8 more
europepmc   +1 more source

Pyridyl‐Thiazole‐Thiosemicarbazones as Antitrypanosomatidae Agents: Design, Synthesis, and In Silico Profiling

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
A novel pyridine–thiazole derivative, Compound 8, exhibited potent dual antitrypanosomatid activity. It demonstrated remarkable in vitro efficacy against Trypanosoma cruzi (IC50 = 1.0 µM) and L. amazonensis (IC50 = 3.9 µM). Molecular docking studies suggested interactions with heme and multiple molecular targets.
Anderson José Firmino Santos da Silva, Daiane Santiago da Cruz Olimpio, Lucas Manoel da Silva Sousa, Graziella Leite Brondani, Tacylla Lima Silva, Wéllyda Belmira de Lira Silva, Natáli Tereza Capistrano Costa, Marcelo Zaldini Hernandes, Policarpo Ademar Sales Junior, Valéria Rêgo Alves Pereira, Ana Cristina Lima Leite   +10 more
wiley   +1 more source

Interactions between cytochrome P450 enzymes and traditional Chinese herbs: A comprehensive review. [PDF]

J Chin Med Assoc
Hsieh YH, Huang ST.
europepmc   +1 more source

Physiologically based pharmacokinetic modeling of fluconazole: interpretation of gender-dependent pharmacokinetics and cytochrome P450 inhibition. [PDF]

Front Pharmacol
Ishida K, Tanna RS, Yang J, Lai Y.
europepmc   +1 more source