Results 41 to 50 of about 35,596 (239)

Pharmacogenomics of CYP2C9: Functional and Clinical Considerations [PDF]

Journal of Personalized Medicine, 2017
CYP2C9 is the most abundant CYP2C subfamily enzyme in human liver and the most important contributor from this subfamily to drug metabolism. Polymorphisms resulting in decreased enzyme activity are common in the CYP2C9 gene and this, combined with narrow therapeutic indices for several key drug substrates, results in some important issues relating to ...
Ann Daly, Allan Rettie, Douglas Fowler, John Miners   +3 more
openaire   +3 more sources

A Phase 1, Randomized, Placebo‐Controlled, Multiple‐Dose, Double‐Blind Study to Evaluate and Compare the Pharmacokinetics and Safety of Rimegepant in Healthy Adult Japanese and Caucasian Individuals

Clinical Pharmacology in Drug Development, EarlyView.
Abstract This Phase 1, randomized, placebo‐controlled, double‐blind study assessed the pharmacokinetic profile of rimegepant (25, 75, or 150 mg once daily for 14 days) in healthy Japanese and Caucasian adults. Exposures were modestly increased in Japanese participants compared with Caucasian participants following a single dose of rimegepant (Day 1 ...
Rajinder Bhardwaj, Chay Ngee Lim, Yinhua Li, Kyle T. Matschke, Richard Bertz, Robert Croop, Jing Liu   +6 more
wiley   +1 more source

The influence of genotype on warfarin maintenance dose predictions produced using a Bayesian dose individualization tool [PDF]

, 2016
Background A previously established Bayesian dosing tool for warfarin was found to produce biased maintenance dose predictions. In the following study, we aimed to (1) determine if the biased warfarin dose predictions previously observed could be ...
Anderson, Boyle, Burmester, Caraco, Chiquette, Fennerty, Finkelman, Gage, Hamberg, Hamberg, Harper, Hillman, Holbrook, Jonas, Keeling, Kim, Kimmel, Klein, Lenzini, Lund, Matchar, Motykie, Pirmohamed, Pitsiu, Saffian, Sconce, Svec, Tait, Vadher, van Walraven, Verhoef, Voora, Wajima, White, White, Witt, Wright, Wright   +37 more
core   +1 more source

Repeated Intake of Grapefruit Juice Inhibits CYP2B6, CYP2C9, CYP2C19, and CYP3A4 while Lingonberry Powder Does Not Induce Major CYP Enzymes in Humans

Clinical Pharmacology &Therapeutics, EarlyView.
Grapefruit juice is a well‐established inhibitor of cytochrome P450 (CYP) 3A4, but its effects on other CYP enzymes or organic anion transporting polypeptides (OATPs) are not fully characterized in humans. Recently, lingonberry powder was shown to induce murine CYP enzymes. We investigated the effects of lingonberry powder and grapefruit juice on seven
Laura Aurinsalo, Outi Lapatto‐Reiniluoto, Mika Kurkela, Mikko Neuvonen, Eeva Moilanen, Mikko Niemi, Aleksi Tornio, Janne T. Backman   +7 more
wiley   +1 more source

A multi-factorial analysis of response to warfarin in a UK prospective cohort [PDF]

, 2016
Background Warfarin is the most widely used oral anticoagulant worldwide, but it has a narrow therapeutic index which necessitates constant monitoring of anticoagulation response.
A Holbrook, A Rouaud, AE Rettie, AH Maitland-van der Zee, AK Hamberg, AL Jorgensen, AL Jorgensen, Andrea Jorgensen, Anita Hanson, Ann K. Daly, AR Tabrizi, BN Howie, BS Finkelman, C Barnes, Cheng Hock Toh, DR Plowchalk, Eunice J. Zhang, F Takeuchi, F Xu, Farhad Kamali, G D’Andrea, GP Aithal, H Furuya, HY Yuan, J Marchini, JB Saunders, L Poller, M Connock, M Ohara, M Pirmohamed, M Pirmohamed, M Wadelius, M Wadelius, M Wadelius, M Wadelius, MA Crowther, Matthew S. Gillman, MD Caldwell, MI Aguilar, MJ Rieder, MT Lee, Munir Pirmohamed, NA Limdi, P Lenzini, Panos Deloukas, Paula Williamson, PJ Avery, R Loebstein, S Purcell, SE Kimmel, SK Ganesh, Stephane Bourgeois, Suzannah Bumpstead, VC Oliveira Almeida de, WE Nostrand Van, YY Teo   +55 more
core   +3 more sources

Improving Genotype Imputation in High‐Dimensional Pharmacogenomics Using Multiple Imputation: Evaluation with Machine Learning Approaches

Clinical Pharmacology &Therapeutics, EarlyView.
Multiple imputation is well‐established for handling missing data, yet its use in high‐dimensional genetic datasets remains limited. Using pharmacokinetic tuberculosis simulations and SNP data (1000 Genomes Project), we compared machine learning (ML) and traditional approaches (e.g., mean imputation and complete‐case analysis) for imputation and ...
Innocent G. Asiimwe, Tao You, Daniel F. Carr, Munir Pirmohamed, Geraint Davies, Andrea L. Jorgensen, on behalf of the UNITE4TB Consortium   +6 more
wiley   +1 more source

Interaction between variants in the CYP2C9 and POR genes and the risk of sulfonylurea-induced hypoglycaemia:A GoDARTS Study [PDF]

, 2017
Data on the association of CYP2C9 genetic polymorphisms with sulfonylurea (SU)-induced hypoglycaemia (SH) are inconsistent. Recent studies showed that variants in P450 oxidoreductase (POR) gene could affect CYP2C9 activity. In this study, we explored the
Donnelly, Louise A., Dujic, Tanja, Leese, Graham, Palmer, Colin N. A., Pearson, Ewan R., Zhou, Kaixin   +5 more
core   +1 more source

Integrated Anatomical, Chemical, Biological and Computational Studies Approach of Myrcia sylvatica (G. Mey) DC. A Multifaceted Insight Into a Promising Amazonian Species

Flavour and Fragrance Journal, EarlyView.
This study presents an integrated anatomical, chemical, biological, and computational analysis of Myrcia sylvatica, revealing key bioactive compounds with antioxidant and toxicological potential, and identifying spathulenol and globulol as promising acetylcholinesterase inhibitors with favourable pharmacokinetic properties. ABSTRACT Myrcia sylvatica (G.
Eliza de Jesus Barros dos Santos, Zelina Ataíde Correia, Ely Simone Cajueiro Gurgel, Leonardo Souza da Costa, Mabrouk Horchani, Hayet Edziri, Ravendra Kumar, Anderson de Santana Botelho, Karyme do Socorro de Souza Vilhena, Eloisa Helena de Aguiar Andrade, Mozaniel Santana de Oliveira   +10 more
wiley   +1 more source

Pharmacogenetics in type 2 diabetes:Influence on response to oral hypoglycemic agents [PDF]

, 2016
Adem Yesuf Dawed, Kaixin Zhou, Ewan Robert Pearson  Division of Cardiovascular and Diabetes Medicine, Medical Research Institute, University of Dundee, Dundee, Scotland, UK Abstract: Type 2 diabetes is one of the leading causes of morbidity ...
Dawed, Adem Yesuf, Pearson, Ewan Robert, Zhou, Kaixin   +2 more
core   +4 more sources

Modifying Antibiotic Activity of Synthetic Thiadiazine Analogs Against MDR Bacteria and ADMET Analysis

ChemistryOpen, EarlyView.
The study demonstrated that thidiazine compounds potentiated the action of antibiotics. The compounds associated with norfloxacin against S. aureus showed greater significance in relation to the other medications. The indiscriminate use of antibiotics has led to the selection of resistant bacterial strains, significantly reducing the effectiveness of ...
João Arthur de Oliveira Borges, Priscilla Ramos Freitas, Isaac Moura Araújo, Ray Silva de Almeida, Igor José dos Santos Nascimento, João Xavier de Araújo‐Júnior, Edeildo Ferreira da Silva‐Júnior, Thiago Mendonça de Aquino, Francisco Jaime Bezerra Mendonça Junior, Emmanuel Silva Marinho, Hélcio Silva dos Santos, Radosław Kowalski, Grażyna Kowalska, Henrique Douglas Melo Coutinho, Saulo Relison Tintino, Ana Carolina Justino de Araújo   +15 more
wiley   +1 more source