Results 81 to 90 of about 18,414 (179)

Stability of Anticoagulation Following Acenocoumarin in Stroke Patients: Role of Pharmacogenomics and Acquired Factors

Annals of Indian Academy of Neurology
Objective: Pharmacogenomics plays an important role in drug metabolism. A stable anticoagulation is important for primary and secondary prevention of cardioembolic stroke and cerebral venous sinus thrombosis (CVST). We report the role of cytochrome P450 (
Ashish Kant Dubey, Jayantee Kalita, Mohammad Firoz Nizami, Surendra Kumar, Usha Kant Misra   +4 more
doaj   +1 more source

Ensemble Docking of FDA‐Approved and Peruvian Phytochemicals Against Monkeypox Virus Telomere‐Binding Protein

ChemistrySelect, Volume 11, Issue 9, 5 March 2026.
ABSTRACT Monkeypox is a reemerging zoonotic disease that has been spreading worldwide. Different approaches are being conducted to find effective treatments for this disease. To accelerate therapeutic discovery, we propose telomere‐binding protein (TBP) as a potential drug target because of its important role during virus maturation.
Edinson Gervacio‐Villarreal, Georcki Ropón‐Palacios, Claudina Sancho, Jhon Pérez‐Silva, Kewin Otazu, Gustavo E. Olivos‐Ramirez, Karolyn Vega‐Chozo, Yaritza L. Ramirez‐Díaz, Manuel E. Chenet‐Zuta, Ivonne Navarro del Aguila, Mario De la Cruz Flores, Cinthia Aguiar, Ihosvany Camps   +12 more
wiley   +1 more source

Cytochrome P450 2C9-CYP2C9 [PDF]

Pharmacogenetics and Genomics, 2010
Derek, Van Booven, Sharon, Marsh, Howard, McLeod, Michelle Whirl, Carrillo, Katrin, Sangkuhl, Teri E, Klein, Russ B, Altman   +6 more
openaire   +2 more sources

Managing High‐Risk Drug Interactions With Nirmatrelvir/Ritonavir: Experience From a Dedicated Pharmacology Advice Service

Clinical and Translational Science, Volume 19, Issue 3, March 2026.
ABSTRACT Nirmatrelvir boosted with ritonavir is a key antiviral against COVID‐19, yet ritonavir's potent CYP3A4 inhibition exposes patients to numerous drug–drug interactions. To make prescribing safer, a national proactive system providing expert pharmacology advice was implemented in France.
Youssef Libiad, Bénédicte Franck, Camille Tron, Sébastien Lalanne, Christelle Boglione‐Kerrien, Fabrice Taïeb, Marie‐Clémence Verdier, Florian Lemaitre   +7 more
wiley   +1 more source

Laying the groundwork: Exploring pesticide exposure and genetic factors in south-eastern Brazilian farmers

Current Research in Toxicology
Brazil is the world leader in pesticide consumption, and its indiscriminate use puts farmers’ health at risk. The CYP2C9 gene encodes the CYP2C9 enzyme, which metabolizes several endogenous substrates and specific xenobiotics, especially pesticides.
Débora Dummer Meira, Victor Nogueira Da Gama Kohls, Matheus Correia Casotti, Luana Santos Louro, Gabriel Mendonça Santana, Thomas Erik Santos Louro, Adriana Madeira Alvares da Silva, Lorena Souza Castro Altoé, Raquel Reis Trabach, Sonia Groisman, Elizeu Fagundes de Carvalho, Jamila Alessandra Perini Machado, Stephanie Seneff, Iúri Drumond Louro   +13 more
doaj   +1 more source

Clinician Satisfaction With Pharmacogenomics Clinical Services at a Multistate Health System

Clinical and Translational Science, Volume 19, Issue 3, March 2026.
ABSTRACT Pharmacogenomics (PGx) utilizes genetic information to optimize medication management. Barriers to PGx implementation include limited confidence and knowledge in applying results, time constraints, and financial barriers. Clinical services across health systems vary greatly with differing consultative PGx service models.
Kristen Jacobsen, Natasha J. Petry, Max Weaver, Ethan Weeder, Amanda Massmann   +4 more
wiley   +1 more source

Knowledge and Attitudes Regarding Pharmacogenetics of Pharmacists in the Netherlands: A National Online Survey Study

Journal of Evaluation in Clinical Practice, Volume 32, Issue 2, March 2026.
ABSTRACT Rationale, Aims and Objectives Pharmacogenetics is considered a promising method to improve pharmacotherapy, yet its implementation in clinical practice is hampered, limiting its potential benefits to the public. Previously, its uptake has been investigated within a variety of healthcare professional groups.
Emma Y. De Brabander, Nicole K. Leibold, Therese van Amelsvoort, Roos van Westrhenen, The PSY‐PGx Consortium, Kristian Kleine Schaars, Sanah Bedi, Allan H. Young, Mario Juruena, Daniel Silman, Urs Heilbronner, Monika Budde, Magnus Ingelman‐Sundberg, Marin Jukic, Martien J. H. Kas, Raj Jagesar, Ramona Moldovan, Markus M. Nöthen, Per Hoffmann, Carina M. Mathey, Alexandra Philipsen, Laura L. Kilarski, Jonathan Laatsch, Noam Shomron, Erik Van der Eycken, Nigel Olisa, Eduard Vieta, Natalia E. Fares‐Otero, Thomas G. Schulze, Therese van Amelsvoort, Bea Campforts, Emma de Brabander, Moritz J. Rossner, Sven P. Wichert, Roos van Westrhenen   +34 more
wiley   +1 more source

Managing the Complex Intersection Between Substance Use Disorders and Infectious Diseases

JACCP: JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY, Volume 9, Issue 3, March 2026.
Karissa Chow, Amanda Binkley, Jessica Meisner, Samantha Huo, Matthew Hinton   +4 more
wiley   +1 more source

The impact of CYP2C9, VKORC1, and CYP4F2 polymorphisms on warfarin dose requirement in Saudi patients

Frontiers in Pharmacology
BackgroundLimited data are available on factors that affect warfarin dose requirement in Saudi patients. Saudis are among the underrepresented ethnic groups in warfarin pharmacogenetics research.
Salha Jokhab, Maha M. AlRasheed, Dana Bakheet, Abdulkareem AlMomen, Nouf AlAboud, Farhad Kamali   +5 more
doaj   +1 more source

Impact of CYP2C9, CYP2C19 and ABCB1 genetic polymorphisms on antiepileptic drug safety and efficacy

Эпилепсия и пароксизмальные состояния
A review of literature data is presented on polymorphic variants of genes responsible for antiepileptic drugs (AEDs) pharmacokinetics: highly polymorphic cytochrome P450 isoenzyme genes CYP2C9 and CYP2C19 as well as the gene ABCB1 encoding transporter ...
N. A. Galankin, Z. G. Tadtaeva, I. S. Sardaryan, A. N. Galustyan, O. A. Gromova   +4 more
doaj   +1 more source