Results 1 to 10 of about 49,005 (303)
Enantioselective analysis of metoprolol in plasma of hypertensive patients undergoing long-term therapy: Insights for personalized medicine [PDF]
BioImpactsIntroduction: Metoprolol is therapeutically formulated as a racemate with stereoselective pharmacokinetics influenced by CYP2D6 polymorphism. Understanding enantioselective disposition is critical for optimizing therapy in hypertensive patients ...
Behrouz Seyfinejad +4 more
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Frequency of CYP2D6*3 and *4 and metabolizer phenotypes in three mestizo Peruvian populations [PDF]
Pharmacia, 2021 Wild type genotypes (CYP2D6) and their allelic variants have been described in a sample of a Peruvian mestizo population. The global allele frequency was 0.015 for CYP2D6*3 and 0.051 for CYP2D6*4. The percentages of genotypes described were 97% CYP2D6*1/*
Angel T. Alvarado +10 more
doaj +3 more sources
In vitro study on the effect of peucedanol on the activity of cytochrome P450 enzymes
Pharmaceutical Biology, 2021 Context Peucedanol is a major extract of Peucedanum japonicum Thunb. (Apiaceae) roots, which is a commonly used herb in paediatrics. Its interaction with cytochrome P450 enzymes (CYP450s) would lead to adverse effects or even failure of therapy ...
Cun Zhang +4 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Aims: The CYP2D6*41 variant is the second or third frequent reduced function allele in Chinese with a frequency of around 3–4%, while it is the major reduced function allele in Indians, Saudi Arabians and Caucasians with frequencies of around 10–20%. The
Ye Jin +6 more
doaj +1 more source
Is CYP2D6 phenotype predictable from CYP2D6 genotype? [PDF]
Microchemical Journal, 2018 Abstract Genetic polymorphism of cytochrome P450s results in clinically significant modifications in patients' drug metabolizing capacities. CYP2D6 has a crucial role in the elimination of several clinically important drugs (antiarrhythmics, beta-adrenergic blockers, psychopharmacons and analgesics); however, the prediction of the phenotypic ...
Ádám Ferenc Kiss +6 more
openaire +2 more sources
CPT: Pharmacometrics & Systems Pharmacology, 2021 The cytochrome P450 (CYP) 2D6 enzyme exhibits large interindividual differences in metabolic activity. Patients are commonly assigned a CYP2D6 phenotype based on their CYP2D6 genotype, but there is a lack of consensus on how to translate genotypes into ...
Trine Frederiksen +4 more
doaj +1 more source
Does ethnicity impact CYP2D6 genotype–phenotype relationships?
Clinical and Translational Science, 2023 Polymorphism of the CYP2D6 gene leads to substantial interindividual variability in CYP2D6 enzyme activity. Despite improvements in prediction of CYP2D6 activity based on genotype information, large interindividual variability within CYP2D6 genotypes ...
Trine Frederiksen +4 more
doaj +1 more source
Development and validation of a next-generation sequencing panel for clinical pharmacogenetics [PDF]
Farmacia Hospitalaria, 2020 La rápida implantación clínica de las técnicas de secuenciación masiva en paralelo se debe a su capacidad para secuenciar un gran número de regiones genéticas con un coste menor a las técnicas convencionales.
Luis Ramudo-Cela +5 more
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Pharmacogenomic testing and its future in community pharmacy [PDF]
, 2020 Although it is common to see pharmacogenomic testing used North America and Australia, it is not yet part of practice in the UK. With the promise of genomic screening becoming part of the NHS, pharmacists must equip themselves with a knowledge of how the
Wright, David, Youssef, Essra
core +1 more source
PharmVar GeneFocus: CYP2D6 [PDF]
Clinical Pharmacology & Therapeutics, 2019 The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly polymorphic human CYP2D6 gene locus. CYP2D6 genetic variation impacts the metabolism of numerous drugs and, thus, can impact drug efficacy and safety. This GeneFocus provides a comprehensive overview and summary of CYP2D6 genetic variation and describes how the ...
Charity Nofziger +12 more
openaire +2 more sources