Results 51 to 60 of about 48,854 (243)

An increase in urinary primaquine and a reduction in urinary primaquine-5,6-orthoquinone in the Thai population with CYP2D6 reduced enzyme function

Heliyon
Objectives: Primaquine is metabolized by the cytochrome P450-2D6 enzyme (CYP2D6) to an active primaquine-5,6-orthoquinone (POQ). No relationships of CYP2D6 polymorphisms with the pharmacokinetics of primaquine and POQ were reported in the Thai population.
Waritda Pookmanee, Siriwan Thongthip, Mathirut Mungthin, Chonlaphat Sukasem, Jeeranut Tankanitlert, Pajaree Chariyavilaskul, Supeecha Wittayalertpanya   +6 more
doaj   +1 more source

Effect of CYP2D6 and ABCB1 polymorphisms on pharmacokinetics and efficacy of aripiprazole in pediatric tic disorders

BMC Pediatrics
Background Aripiprazole (ARI) is the first-line treatment for tic disorders (TD). Cytochrome P450(CYP)2D6 (CYP2D6) and ATP-binding cassette, sub-family B, member 1 (ABCB1) transporter are involved in the metabolism of ARI.
Yingying Xin, Liuliu Gao, Sichan Li, Jun Wang, Chen Chen, Yali Tuo, Gang Nie, Ruizhen Li, Dan Sun, Yongli Fu, Yang Wang, Zhisheng Liu   +11 more
doaj   +1 more source

CYP2D6 genotype and adjuvant tamoxifen:meta-analysis of heterogeneous study populations [PDF]

, 2014
The International Tamoxifen Pharmacogenomics Consortium was established to address the controversy regarding cytochrome P450 2D6 (CYP2D6) status and clinical outcomes in tamoxifen therapy. We performed a meta-analysis on data from 4,973 tamoxifen-treated
Altman, R. B., Altman, Russ B., Ambrosone, C. B., Ambrosone, Christine A., Ambrosone, Christine B., Ames, M. M., Beckmann, M. W., Beckmann, Matthias W., Boländer, Julia, Brauch, H., Brauch, Hiltrud, Choi, J. Y., Choi, Ji Yeob, Dieudonné, A. S., Dieudonné, Anne Sophie, Eichelbaum, M., Eichelbaum, Michel, Fasching, P. A., Fasching, Peter A., Ferraldeschi, R., Ferraldeschi, Roberta, Fischer-Bosch, Margarete, Flockhart, D. A., Flockhart, David A., Fritz, Peter, Goetz, M. P., Goetz, Matthew P., Gong, L., Gong, Li, H, Elad Ziv, Hamann, U., Hamann, Ute, Haschke-Becher, E., Haschke-Becher, Elisabeth, Hebert, J. M., Hebert, Joan M., Howell, Anthony, Ingle, J. N., Ingle, James N., Jordan, L. B., Jordan, Lee B., Jordan, V. C., Kiyotani, K., Kiyotani, Kazuma, Klein, T. E., Klein, Teri E., Koelbl, Heinz, Krippl, P., Lambrechts, D., Lambrechts, Diether, Langsenlehner, U., Latif, A., Latif, Ayse, Lee, M. T M, Lorizio, W., Lorizio, Wendy, Mushiroda, T., Mushiroda, Taisei, Nakamura, Y., Neven, P., Neven, Patrick, Newman, W. G., Newman, William G., Nguyen, A. T., Nguyen, Anne T., Park, B. W., Park, Byeong Woo, Province, M. A., Province, Michael A., Purdie, C. A., Purdie, Colin A., Quinlan, P., Quinlan, Philip, Renner, W., Schmidt, M., Schmidt, Marcus, Schroth, W., Schroth, Werner, Schwab, M., Schwab, Matthias, Shin, J. G., Shin, Jae Gook, Simon, Wolfgang, Stingl, J. C., Stingl, Julia C., Strick, Reiner, Suman, V. J., Suman, Vera J., Thompson, A. M., Thompson, Alastair M., Ulmer, Hans Ulrich, Wegman, P., Wegman, Pia, Weinshilboum, R. M., Weinshilboum, Richard M., Whaley, R., Whaley, Ryan, Wingren, S., Wingren, Sten, Winter, S., Winter, Stefan, Wu, A. H B, Wu, Alan H B, Zembutsu, H., Zembutsu, Hitoshi, Zirpoli, G., Ziv, E., Ziv, Elad   +107 more
core   +3 more sources

Metabolism and Metabolic Inhibition of Xanthotoxol in Human Liver Microsomes [PDF]

, 2016
Cytochrome p450 (CYP450) enzymes are predominantly involved in Phase I metabolism of xenobiotics. In this study, the CYP450 isoforms involved in xanthotoxol metabolism were identified using recombinant CYP450s.
Cai, Jiqun, Guo, Feng, Ma, Zhongnv, Shan, Lina, Shi, Xianbao, Zhang, Gang   +5 more
core   +5 more sources

The relationship between plasma concentration of metoprolol and CYP2D6 genotype in patients with ischemic heart disease [PDF]

, 2014
Background Metoprolol is the one of the most commonly used β-blockers in the treatment of ischemic heart disease and it is extensively metabolized in the liver undergoing oxidation by CYP2D6 isoenzyme of cytochrome P450.
Skrętkowicz, Jadwiga, Wojtczak, Anna, Wojtczak, Maciej   +2 more
core   +1 more source

Beyond Cholinesterase Inhibition. Anti-Inflammatory Role and Pharmacological Profile of Current Drug Therapy for Alzheimer's Disease [PDF]

, 2016
Inflammation is a common response of an individual against either exogenous or endogenous damage. The role of inflammation and of inflammatory cells recently emerged also in the pathogenesis of neurodegenerative disorders. Experimental evidences show how
GIUBILEI, Franco
core   +1 more source

Carboplatin/taxane-induced gastrointestinal toxicity: a pharmacogenomics study on the SCOTROC1 trial [PDF]

, 2016
Carboplatin/taxane combination is first-line therapy for ovarian cancer. However, patients can encounter treatment delays, impaired quality of life, even death because of chemotherapy-induced gastrointestinal (GI) toxicity.
Brown, R., Glass, S., He, Y.J., Hoskins, J.M., McLeod, H.L., Motsinger-Reif, A., Paul, J., Winham, S.J.   +7 more
core   +1 more source

Genetic polymorphism of cytochrome p450 (2C19) enzyme in Iranian Turkman ethnic group [PDF]

, 2013
Objective: Different findings indicate that CYP2C plays a clinical role in determining interindividual and interethnic differences in drug effectiveness. The ethnic differences in the frequency of CYP2C19 mutant alleles continue to be a significant study
Ataby, O.A., Mansourian, A.R., Marjani, A., Samai, N.M., Tabari, R.G.   +4 more
core   +2 more sources

Development of Customizable Implementation Guides to Support Clinical Adoption of Pharmacogenomics: Experiences of the Implementing GeNomics In pracTicE (IGNITE) Network

Pharmacogenomics and Personalized Medicine, 2020
Benjamin Q Duong,1 Meghan J Arwood,2 J Kevin Hicks,3 Amber L Beitelshees,4 Francesco Franchi,5 John T Houder,2 Nita A Limdi,6 Kelsey J Cook,7,8 Aniwaa Owusu Obeng,9 Natasha Petry,10 Sony Tuteja,11 Amanda R Elsey,2 Larisa H Cavallari,2 Kristin Wiisanen2 ...
Duong BQ, Arwood MJ, Hicks JK, Beitelshees AL, Franchi F, Houder JT, Limdi NA, Cook KJ, Owusu Obeng A, Petry N, Tuteja S, Elsey AR, Cavallari LH, Wiisanen K   +13 more
doaj  

CYP2D6 activity and the risk of recurrence of Plasmodium vivax malaria in the Brazilian Amazon: a prospective cohort study

Malaria Journal, 2018
Background CYP2D6 pathway mediates the activation of primaquine into active metabolite(s) in hepatocytes. CYP2D6 is highly polymorphic, encoding CYP2D6 isoforms with normal, reduced, null or increased activity.
Larissa W. Brasil, Fernanda Rodrigues-Soares, Ana B. Santoro, Anne C. G. Almeida, Andrea Kühn, Rajendranath Ramasawmy, Marcus V. G. Lacerda, Wuelton M. Monteiro, Guilherme Suarez-Kurtz   +8 more
doaj   +1 more source