Results 141 to 150 of about 61,480 (319)
Journal of Veterinary Pharmacology and Therapeutics, EarlyView.ABSTRACT Pharmacokinetics (PK) of intramuscular (IM) and subcutaneous (SC) ketamine in horses has not been described. This study aimed to evaluate the PK and safety of ketamine and its metabolites after a single SC or IM administration. In Phase 1, two horses received 0.5 or 1 mg/kg of ketamine via SC and IM routes.
Ana Rangel +5 more
wiley +1 more source
The Effect of Ecopipam on the Pharmacokinetics of Concomitant Medications [PDF]
Clin Transl SciABSTRACT Ecopipam is a first‐in‐class dopamine D1 receptor antagonist under investigation for the treatment of Tourette syndrome. This open‐label, fixed‐sequence, three‐cohort study evaluated whether ecopipam induces or inhibits cytochrome P450 (CYP) 1A2, CYP2B6, CYP2C19, CYP2D6, CYP3A4, organic anion‐transporting polypeptide (OATP) 1B1, and p ...
Schmith V +4 more
europepmc +2 more sources
Transforming Treatment: The Impact of Bariatric Surgery on Oral Drug Absorption
Obesity Reviews, EarlyView.ABSTRACT Obesity represents a significant threat to global public health, with an estimated 16% of adults worldwide (2022) being classified as people with obesity, with a body mass index of 30 or more. Bariatric surgery is regarded as the most effective treatment option for people with obesity, with the three main types of bariatric surgery being ...
Danielle Wigg +3 more
wiley +1 more source
Drug Development Research, Volume 87, Issue 2, April 2026.ABSTRACT The roots of the climbing shrub Cryptolepis sanguinolenta are traditionally used in West Africa for the treatment of malaria. The principal constituent, cryptolepine (1), has been shown to have antimalarial activity but there are concerns regarding its toxicity on account of its DNA‐intercalating property.
Elodie Chenu +7 more
wiley +1 more source
Hepatic CYP3A4 Enzyme Compensatively Maintains Endogenous Geranylgeranoic Acid Levels in MAOB-Knockout Human Hepatoma Cells [PDF]
, 2022 Yuki Tabata, Yoshihiro Shidoji
openalex +1 more source
Traditional &Kampo Medicine, Volume 13, Issue 1, April 2026.ABSTRACT Aim One of the effects of Cistanche herb is described in the Chinese Pharmacopoeia as for lack of strength in muscles and bones. However, concrete evidence of this herb for muscle strength has been hardly reported. The present study aimed to clarify the effects of 30% ethanolic extract of Cistanche tubulosa fleshy stem on muscle strength and ...
Jae‐Won Jung, Chihiro Tohda
wiley +1 more source