Results 131 to 140 of about 56,913 (295)

Ligand Diversity of Human and Chimpanzee CYP3A4: Activation of Human CYP3A4 by Lithocholic Acid Results from Positive Selection□S

, 2008
For currently unknown reasons, the evolution of CYP3A4 under-went acceleration in the human lineage after the split from chim-panzee. We investigated the significance of this event by com-paring Escherichia coli-expressed CYP3A4 from humans, chimpanzee ...
Santosh Kumar, James R. Halpert, Numan Oezguen, Huan Qiu, Holger Herlyn, Leszek Wojnowski   +5 more
core  

Research Progress of Berberine in Kidney Disease: Targeting Mitochondria and Ferroptosis

iNew Medicine, EarlyView.
This figure illustrates the model‐specific renoprotective mechanisms of berberine (BBR) across three major kidney diseases. From left to right, the diagram shows that BBR targets distinct core pathways depending on the pathological context: in diabetic nephropathy (DN), BBR activates AMPK to improve mitochondrial energy metabolism; in acute kidney ...
Liuqing Wang, Rongyu Guo, Xiaojun Feng, Liqin Tang   +3 more
wiley   +1 more source

KLF15 as a Metabolic Gatekeeper Linking Drug Metabolism, Toxicity, and Precision Therapeutics

iNew Medicine, EarlyView.
KLF15‐mediated metabolic preconditioning links metabolic state to drug disposition, therapeutic efficacy, and adverse effects, extending classical xenobiotic sensing toward precision pharmacology. ABSTRACT Krüppel‐like factor 15 (KLF15) is emerging as a metabolic‐state‐sensitive regulator of hepatic endobiotic and xenobiotic metabolism.
Shilin Li, Xue Li, Zhengding Su, Shuxin Han   +3 more
wiley   +1 more source

Association of CYP3A4 genotype with treatment-related leukemia

, 1998
Epipodophyllotoxins are associated with leukemias characterized by translocations of the MLL gene at chromosome band 11q23 and other translocations. Cytochrome P450 (CYP) 3A metabolizes epipodophyllotoxins and other chemotherapeutic agents.
Cheung, N K, Lange, B J, Williams, T M, Lovett, Brian D, MD, Blair, I A, Felix, C A, Winick, N J, Rebbeck, T R, Powell, P C, Walker, A H   +9 more
core   +1 more source

Omeprazole Induces CYP3A4 mRNA Expression but Not CYP3A4 Protein Expression in HepaRG Cells.

Biological & pharmaceutical bulletin
Unknown interactions between drugs remain the limiting factor for clinical application of drugs, and the induction and inhibition of drug-metabolizing CYP enzymes are considered the key to examining the drug-drug interaction (DDI). In this study, using human HepaRG cells as an in vitro model system, we analyzed the potential DDI based on the expression
Fujita, Yuto, Miyake, Takahito, Shao, Xinyan, Aoki, Yuto, Hasegawa, Emi, Doi, Masao   +5 more
openaire   +2 more sources

Transcriptional control of the human CYP3A4 gene. [PDF]

, 2018
CYP3A4 is the most abundant P450 enzyme expressed in the human liver and it is responsible for the metabolism of approximately 50% of all clinically administrated drugs.
Bombail, Vincent.
core  

Biological Effects of Selenium‐Containing Ionic Liquids: Cytotoxicity, Mercury Interaction, and Antiproliferative Activity in Glioblastoma Cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT Selenium (Se) is an essential micronutrient that participates in redox regulation and cellular homeostasis. Selenium‐containing ionic liquids (ILsSe) have emerged as hybrid compounds combining the properties of organoselenium molecules with the tunable features of ionic liquids.
Guilherme Schmitt Rieder, Alessandro de Souza Prestes, Fernanda D'Avila da Silva, Nilda de Vargas Barbosa, Alix Y. Bastidas Ángel, Mariana F. Soares, Carolina Martins Fernandes, Maria Anttônia Oliveira Petersen, Manuela Moura Silva, Juliete Nathali Scholl, Fabrício Figueiró, Pablo Andrei Nogara, Laura Orian, Eduardo E. Alberto, Michael Aschner, Diogo Onofre Gomes de Souza, Debora Guerini de Souza, João Batista Teixeira da Rocha   +17 more
wiley   +1 more source

DEVELOPMENT AND VALIDATION OF SIMULTANEOUS ASSAY OF SUBSTRATES-MARKERS OF MAIN CYTOCHROME P450 ISOFORMS AND THEIR METABOLITES USING HPLC-MS/MS

Разработка и регистрация лекарственных средств, 2019
Simultaneous quantification method of assaying main CYP isoforms substrates-markers and their metabolites in urine using HPLC-MS/MS was developed to determine activity of following isoforms: caffeine/paraxanthine for CYP1A2, losartane/E-3174 for CYP2C9 ...
E. A. Egorenkov, V. V. Smirnov
doaj  

Genetic polymorphism of CYP3A4 associated with reduced response to statin therapy in Pakistani cardiac and dyslipidemic patients: A cross-sectional observational study

Pakistan Journal of Pharmaceutical Sciences
Background: Drug resistance phenomenon has become a serious problem in the lipid lowering drugs in the treatment of cardiac and dyslipidemic patients. Statins are the mainstay pharmacological treatment for dyslipidemia, metabolized by CYP3A4 gene. CYP3A4
Hafiz Rafay Rawaal, Amina Arif, Adil Jamal, Kashif- ur- Rehman   +3 more
doaj   +1 more source

Therapeutic‐dose verapamil‐induced cardiogenic shock in an older patient: a case report

Journal of Pharmacy Practice and Research, EarlyView.
Abstract Background Calcium channel blocker (CCB) toxicity most commonly follows deliberate overdose. However, severe toxicity at therapeutic doses may occur in susceptible individuals. Severe CCB toxicity often presents with clinical features of bradycardia, hypotension, hyperglycaemia, and lactic acidosis.
Christopher Thuring, Maria Carey, Timothy Webber, Biswadev Mitra   +3 more
wiley   +1 more source