Results 141 to 150 of about 56,913 (295)

CYP3A4 and CYP3A5 Genes in Cyclophosphamide-treated Chronic Lymphocytic Leukemia Patients: A Pharmacogenetics Study

Frontiers in Bioscience-Scholar
Background: Approximately 75% of drug metabolism in clinical settings is attributed to cytochrome P450 enzymes. This study aimed to assess the effects of the CYP3A4*1B and CYP3A5*3 genetic variations on the clinical results of ...
Heba M. Elmaraghy, Menna Al-Adl, Eman R. Saifeldein, Sahar M. Elashmony, Magdy M. Youssef, Afaf El-Said, Sherif Refaat, Abdallah E. Mohammed   +7 more
doaj   +1 more source

CYP3A4 Gene [PDF]

, 2020
openaire   +1 more source

Time Dependent Inhibition Of CYP3A4 Was The Potent Reason For High-Frequency Clinical Drug-Drug Interaction Of Erlotinib

, 2010
Background: To expain the high frenquency drug-drug interactions of erlotinib, the inhibition potential and kinetic information of erlotinib to seven CYP isoforms was investigated.
张延延, 房中则, 葛广波, Ling Yang, 李巍, 杨凌, 董佩佩, 朱亮亮, 毛玉玺   +8 more
core  

Gymnema sylvestre: Bioactive constituents, health benefits, and emerging applications in nutraceuticals and functional foods

JSFA reports, EarlyView.
Abstract Gymnema sylvestre (Retz.) R.Br. ex‐Schult., commonly known as “gurmar” or “sugar destroyer,” belongs to the Apocynaceae family and is traditionally used in Ayurveda for diabetes management. This review synthesizes ethnomedicinal evidence with contemporary pharmacological studies, to evaluate the therapeutic properties and mechanistic actions ...
Faiza Saeed, Muhammad Tauseef Sultan, Hassan Raza, Ahmad Mujtaba Noman, Nimra Haroon, Entessar Mohammad Al Jbawi   +5 more
wiley   +1 more source

Половые различия в биотрансформации лекарственных средств: значение для проведения клинических исследований лекарственных средств

Фармакокинетика и Фармакодинамика, 2020
Долгое время клинические исследования лекарственных средств I и II фазы у женщин не проводились, что было связано с опасениями негативного воздействия на возможную беременность и плод.

doaj  

CYP3A4 Substrate [PDF]

, 2020
openaire   +1 more source

Lipid Dependence of CYP3A4 Activity in Nanodiscs

Biology
CYP3A4 is the main xenobiotic metabolizing enzyme in the human body, as it is in volved in metabolism of ~30% of drugs on the market as well as of many other compounds, from small molecules such as ethanol to large drugs such as erythromycin and cyclosporine [...]
Ilia G. Denisov, Yelena V. Grinkova, Stephen G. Sligar   +2 more
openaire   +2 more sources

Neurological Adverse Effects Associated With Commonly Used H1‐Antihistamines: A Narrative Review of Age‐Stratified Risk Profiles in Paediatric and Geriatric Populations

Medicine Advances, EarlyView.
This narrative review examines the neurological adverse effects associated with commonly used H1‐antihistamines, focusing on how blood–brain barrier (BBB) penetration and patient age influence central nervous system (CNS) toxicity. The major finding is that first‐generation antihistamines, because of higher CNS penetration, are associated with ...
Syeda Samia Fatima, Zahabia Adnan, Rabia Nizam, Marium Fawad, Zainab Mehmood, Areeba Asif, Ali Aamir   +6 more
wiley   +1 more source

CYP3A4 Inhibitor [PDF]

, 2020
openaire   +1 more source

Physiologically based pharmacokinetic modeling and simulation of topiramate in populations with renal and hepatic impairment and considerations for drug–drug interactions

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 510-522, March 2025.
Abstract Topiramate (TPM) is a broad‐spectrum antiepileptic drug (AED) commonly prescribed for approved and off‐label uses. Routine monitoring is suggested for clinical usage of TPM in special population due to its broad side effect profile. Therefore, it is crucial to further explore its pharmacokinetic characteristics.
Shuqing Chen, Chaozhuang Shen, Yuchen Tian, Yuhe Peng, Jing Hu, Haitang Xie, Ping Yin   +6 more
wiley   +1 more source