Results 141 to 150 of about 43,637 (267)

Dexamethasone-Mediated Regulation of CYP3A4 and UGTs in Human Hepatoma HuH-7 Cells. [PDF]

Fundam Clin Pharmacol
Yu H, Lee SH, Kim JH, Kim SJ, Kang HE.
europepmc   +1 more source

Dolutegravir population pharmacokinetics in racially, sex‐ and age‐diverse and antiretroviral therapy‐experienced adults with HIV in the United States

HIV Medicine, EarlyView.
Abstract Objectives Dolutegravir (DTG) has been associated with weight gain in women with HIV, Black people with HIV and people with HIV60 years. This study aimed to characterise DTG population pharmacokinetics (PopPK) in a diverse population including these sub‐populations.
Adrian Khoei, Andrew Edmonds, Yen Chang, Catalina Ramirez, Mackenzie Vogan, Amanda Poliseno, Steven Wolinsky, Ken Ho, Todd T. Brown, Joseph B. Margolick, Jacquett Batson, Jennifer Hoffmann, Mark A. Marzinke, Mirjam‐Colette Kempf, Maria L. Alcaide, Joffi Effoe, Cecile D. Lahiri, Igho Ofotokun, Anandi N. Sheth, Stephen Gange, Audrey L. French, Bani Tamraz, Bradley E. Aouizerat, Phyllis C. Tien, Seble G. Kassaye, Jack DeHovitz, Kathryn Anastos, Kara W. Chew, Michelle Floris‐Moore, Julie B. Dumond   +29 more
wiley   +1 more source

Candidate-gene-based study of CYP3A-related single-nucleotide polymorphisms using 4β-hydroxycholesterol/cholesterol ratio as biomarker in a Japanese cohort. [PDF]

Eur J Clin Pharmacol
Tanaka R, Suzuki Y, Koyama T, Sumimoto T, Oda A, Sato H, Ozaki E, Tatsuta R, Yamamoto Y, Nakatochi M, Momozawa Y, Ohno K, Takashima N, Matsuo K, Itoh H.   +14 more
europepmc   +1 more source

Early Bleeding Risk After DOAC Initiation With Concomitant Amiodarone in Older Adults With Atrial Fibrillation

Journal of Cardiovascular Electrophysiology, EarlyView.
ABSTRACT Background Amiodarone is frequently co‐prescribed with direct oral anticoagulants (DOACs) in atrial fibrillation (AF), but its impact on early bleeding risk after DOAC initiation in older adults remains uncertain. We evaluated short‐term safety outcomes associated with concomitant amiodarone use at the time of DOAC initiation.
Isadora D. Guarino, Saman Nazarian
wiley   +1 more source

TNFAIP1 suppresses hepatocellular carcinoma progression via the PXR/CYP3A4 signaling axis. [PDF]

Am J Cancer Res
Nie Q, Guo Y, Xiao H, Zhang D, Li H, Wang L.   +5 more
europepmc   +1 more source

Treatment Goals for Primary Biliary Cholangitis, an Australian Perspective

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Primary biliary cholangitis (PBC) is an autoimmune liver disease that targets the small intrahepatic bile ducts with diagnosis based on elevated serum alkaline phosphatase (ALP) levels and the presence of anti‐mitochondrial antibodies. Untreated, it may run a progressive course to cirrhosis and hepatic decompensation, at which point liver ...
Simone I. Strasser, Alexander J. Thompson, Rohit Gupta, John Lubel, Janine French, Beverly Sacks, Martin Weltman   +6 more
wiley   +1 more source

In Vitro Cytochrome P450 Interaction Profile and ADME Characterisation of Gold(I)-Triphenylphosphine Complexes with 6-Alkoxy-9-deazapurine Ligands. [PDF]

Pharmaceutics
Medvedíková M, Vančo J, Trávníček Z, Anzenbacher P.   +3 more
europepmc   +1 more source

The DOAC‐FRAIL Study—Same Dose, Different Story: Prevalence of Deviant Direct Oral Anticoagulant Levels in Nursing Home Residents

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background Direct oral anticoagulants (DOACs) are prescribed using fixed dosing regimens, despite limited evidence on their pharmacokinetic behavior in nursing home residents. Participants and Setting One hundred nursing home residents are receiving apixaban, rivaroxaban, dabigatran, or edoxaban in multiple long‐term care facilities in the ...
Irme S. Franssen, Melanie J. de Jong, Lars Visseren, Daan Teerds, Dave Hellenbrand, Yvonne Henskens, Henri Spronk, Daisy J. A. Janssen, Dionne C. W. Braeken, Sander M. J. van Kuijk, Kristien Winckers, Fabienne J. H. Magdelijns   +11 more
wiley   +1 more source

Label-Free High-Throughput Screening of CYP3A4 Inhibitors Using Acoustic Ejection Mass Spectrometry. [PDF]

Anal Chem
Rimmer MA, Wang J, Ranathunge TA, Shi Z, Li Y, Lee D, Chai SC, Lin W, Twarog NR, Ansari AZ, Shelat AA, Young BM, Chen T, Yang L.   +13 more
europepmc   +1 more source

Integrating Pharmacogenomic Testing Within the 4Ms Framework for Management of Behavioral Symptoms in Advanced Vascular Dementia: A Case Study

Journal of the American Geriatrics Society, EarlyView.
Pharmacogenomic‐guided managment of behavioral symptoms within the 4Ms framework.
Gianna Franco, Collins Njoku, Mary L. Wagner, Fred A. Kobylarz   +3 more
wiley   +1 more source