World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Background Chronic rhinosinusitis (CRS) and nasal polyps (NP) are chronic inflammatory conditions with unsatisfactory treatment outcomes due to frequent recurrence of refractory disease. Identifying new therapeutic targets is essential. Methods We conducted a proteome‐wide Mendelian randomization (MR) analysis by integrating genome‐wide ...
En Zhou +4 more
wiley +1 more source
Residue 208 of UGT1A7 Determines the Functional Consequences of CYP3A4-UGT1A7 Association in Living Cells. [PDF]
Biology (Basel)Egoshi N +7 more
europepmc +1 more source
, 2006 Objective: To study the metabolism of medroxyprogesterone acetate (MPA) in human liver microsomes and compare the metabolim profile with rat, minipig liver mcirosomes and recombinant human CYP3A4.
张江伟, 李巍, 刘勇, 杨凌
core
Advent of NK3R Antagonists for the Treatment of Menopausal Hot Flushes: A Narrative Review
BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.ABSTRACT The menopause transition is marked by symptoms predominantly attributed to declining oestrogen levels. Approximately 80% of women experience associated symptoms, and 25% experience severe symptoms. The commonest are vasomotor symptoms (VMS), collectively referring to hot flushes and/or night sweats.
Aaran H. Patel +5 more
wiley +1 more source
Genetic Polymorphisms <i>CYP3A4*22</i>, <i>CYP3A5*3</i>, and CYP2D6 Predicted Phenotypes Are Not Associated with Antipsychotic Treatment Outcomes in Neurotypical Prepubertal Boys with Conduct Disorders. [PDF]
Pharmaceuticals (Basel)Ivashchenko DV +12 more
europepmc +1 more source
Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges
British Journal of Pharmacology, EarlyView.This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu +6 more
wiley +1 more source
Real-World Claims Data on Prescribed Drugs and the Associated Drug-Drug Interaction Risk in Sickle Cell Disease in the United States. [PDF]
Clin Transl SciNørgaard RA +4 more
europepmc +1 more source
Heart failure medication to prevent cancer therapy–related cardiac dysfunction: A narrative review
British Journal of Pharmacology, EarlyView.Advances in oncological therapies have improved cancer survival but also have increased the clinical incidence of cancer therapy–related cardiac dysfunction (CTRCD), a spectrum of conditions ranging from subclinical biomarker or strain abnormalities to progressive heart failure and cardiogenic shock.
Fabian Voß +3 more
wiley +1 more source
Bruton tyrosine kinase inhibitors and cardiovascular adverse events
British Journal of Pharmacology, EarlyView.Abstract Bruton tyrosine kinase inhibitors (BTKi) have transformed the management of chronic lymphocytic leukaemia and other B‐cell malignancies, yet their therapeutic benefit is tempered by clinically relevant cardiovascular toxicities (predominantly atrial fibrillation, hypertension, bleeding and ventricular arrhythmias).
Massimiliano Camilli +4 more
wiley +1 more source
Metabolic Insights into Coumarins from Angelica Dahurica Radix: Underlying Mechanisms of Herb-Drug Interactions. [PDF]
Drug Des Devel TherRao J +7 more
europepmc +1 more source