Results 181 to 190 of about 76,948 (211)

CYP3A4*22: Promising Newly IdentifiedCYP3A4Variant Allele for Personalizing Pharmacotherapy

Pharmacogenomics, 2012
Many studies have attempted to explain the interindividual variability observed in drug metabolism by assessing the impact of SNPs in genes implicated in drug absorption, distribution, metabolism and excretion pathways. Particular attention has been paid to the CYP450s.
Elens, Laure, Gelder, Teun, Hesselink, Dennis, Haufroid, V, van Schaik, Ron   +4 more
openaire   +3 more sources

Transport and Metabolic Characterization of Caco-2 Cells Expressing CYP3A4 and CYP3A4 Plus Oxidoreductase

Pharmaceutical Research, 1999
To further characterize CYP3A4-transfected Caco-2 cells with regard to morphological, transport, and metabolic properties, and to evaluate a different Caco-2 cell strain transfected with both CYP3A4 and oxidoreductase (OR).Transfected Caco-2 cells, Caco-2 TC7 cells, and wild-type Caco-2 cells grown onto Millicell were used.
M, Hu, Y, Li, C M, Davitt, S M, Huang, K, Thummel, B W, Penman, C L, Crespi   +6 more
openaire   +2 more sources

Identification and characterization of CYP3A4*20, a novel rare CYP3A4 allele without functional activity

Clinical Pharmacology & Therapeutics, 2006
The major drug-metabolizing enzyme cytochrome P450 (CYP) 3A4 is genetically conserved. One outlier of Brazilian descent was found in a clinical pharmacokinetic trial exhibiting a 6-fold higher exposure than expected to an investigational drug, shown to be a CYP3A4 substrate.
Anna, Westlind-Johnsson, Robert, Hermann, Andreas, Huennemeyer, Bernhard, Hauns, Gezim, Lahu, Nassr, Nassr, Karl, Zech, Magnus, Ingelman-Sundberg, Oliver, von Richter   +8 more
openaire   +2 more sources

Genetic polymorphisms of CYP3A4: CYP3A4⁎18 allele is found in five healthy Malaysian subjects

Clinica Chimica Acta, 2007
Cytochrome P450 3A4 (CYP3A4) is the major cytochrome involved in metabolizing of >60% of all drugs used in humans. A number of allelic variations in CYP3A4 gene are known to affect catalytic activity including CYP3A4*4, CYP3A4*5 and CYP3A4*18. We investigated the frequencies of CYP3A4*4, CYP3A4*5 and CYP3A4*18 alleles in a Malaysian population.
A B, Ruzilawati, A W Mohd, Suhaimi, S H, Gan   +2 more
openaire   +2 more sources

CYP3A4*1G regulates CYP3A4 intron 10 enhancer and promoter activity in an allelicdependent manner

Int. Journal of Clinical Pharmacology and Therapeutics, 2015
CYP3A4*1G (G > A) in human CYP3A4 intron 10 is associated with therapeutic effects of CYP3A4-metabolized drugs. The aim of this study was to predict its function in the regulation of CYP3A4 expression.Functional analysis of the CYP3A4*1G allele was performed using bioinformatic methods and enhancer or promoter reporter assays in HepG2 cells ...
Weihong, Yang, Dengzhi, Zhao, Shengna, Han, Zengyuan, Tian, Liang, Yan, Guoqiang, Zhao, Quancheng, Kan, Wei, Zhang, Lirong, Zhang   +8 more
openaire   +2 more sources

Statin Regulation of CYP3A4 and CYP3A5 Expression

Pharmacogenomics, 2009
CYP3A4 and CYP3A5 are cytochrome P450 enzymes that are highly expressed in the liver and gut and metabolize endogenous compounds and xenobiotics. Statins are cholesterol-lowering drugs that are extensively metabolized by CYP3A4 and CYP3A5. The bioavailability of statins is affected by CYP3A4 and CYP3A5 and glucuronidases metabolism as well as uptake ...
Maria Alice Vieira, Willrich, Mario Hiroyuki, Hirata, Rosario Dominguez Crespo, Hirata   +2 more
openaire   +2 more sources

Genetic epidemiology of induced CYP3A4 activity

Pharmacogenetics and Genomics, 2011
The cytochrome P450 3A4 (CYP3A4) enzyme is implicated in the metabolism of more than 50% of all prescribed medications and its activity - including induced or inhibited activity - is deemed to be a crucial determinant of interindividual variability in drug disposition, poor therapeutic efficacy, and adverse response to medication.We used the classical ...
Rahmioglu, Nilufer, Heaton, James, Clement, Gail, Gill, Raj, Surdulescu, Gabriela, Zlobecka, Karolina, Hodgkiss, Dylan, Ma, Yongmin, Hider, Robert C., Smith, Norman W., Ahmadi, Kourosh R.   +10 more
openaire   +3 more sources

The expression of intestinal CYP3A4 in the piglet model

Transplantation Proceedings, 2004
In our previous study, the blood levels of tacrolimus were higher in the short bowel and small bowel transplantation models than those in controls. Metabolism by intestinal cytochrome p450 3A4 (CYP3A4) has been reported to influence the blood level of orally administered tacrolimus.
K, Nishi, T, Ishii, M, Wada, S, Amae, N, Sano, M, Nio, Y, Hayashi   +6 more
openaire   +2 more sources

CYP3A4∗22 Genotyping in Clinical Practice: Ready for Implementation?

Frontiers in Genetics, 2021
Tessa A M Mulder, Ruben A G van Eerden, Mirjam de With   +2 more
exaly  

CYP3A4 and the erythromycin breath test

Clinical Pharmacology & Therapeutics, 1998
openaire   +2 more sources