Results 181 to 190 of about 43,637 (267)

Comprehensive Investigation of Benzimidazolium Derivatives Through Synthesis, Characterization, Cytotoxicity Activity, Immunocytochemistry, and ADME and Toxicity Analyses

ChemistryOpen, Volume 15, Issue 9, September 2026.
Three benzimidazolium derivatives bearing fluoro, chloro, and methoxy substituents are synthesized and evaluated for anticancer activity. Compound 2b shows the highest antiproliferative activity and induces apoptosis through caspase‐3 activation and PARP1 cleavage. In this study, three novel benzimidazolium derivatives (2a–c) bearing 4‐fluoro, 3‐chloro,
Gulay Dilek, Senem Akkoc
wiley   +1 more source

Sustained Drug-Drug Interaction Between Cyclosporine and Apalutamide in a Patient With Metastatic Hormone-Sensitive Prostate Cancer: A Case Report and Evaluation of CYP3A4 Induction via Pregnane X Receptor Activation by Apalutamide. [PDF]

Case Rep Oncol Med
Mimura Y, Sanda T, Unno R, Furukawa Y, Shizu R, Motokatsu K, Tashiro Y, Tasaki Y, Sugiyama Y, Yasujima T, Naiki T, Horita Y, Hotta Y, Yuasa H, Yoshinari K, Yasui T, Iida S, Furukawa-Hibi Y.   +17 more
europepmc   +1 more source

Integrated In Silico Discovery of Thymoquinone Analogs Targeting the Keap1–Nrf2 Pathway for Amyotrophic Lateral Sclerosis Therapy

ChemistryOpen, Volume 15, Issue 9, September 2026.
Integrated in silico discovery of thymoquinone analogs as potent Keap1 inhibitors for ALS therapy. Using validated QSAR, docking, and 200 ns MD simulations, we identified brain‐penetrant leads (CHEMBL3416163, CHEMBL4636830, and CHEMBL221598) with binding affinities up to fourfold stronger than thymoquinone, offering a targeted strategy to restore redox
Jabir C. Nalicho, Petro E. Mabeyo, Andrew S. Paluch, Lucas Paul   +3 more
wiley   +1 more source

In Silico Comparison of Rifampicin and 25-desacetyl Rifampicin-Induced PXR-Mediated CYP450 Transcriptional Response in 3D Primary Human Hepatocytes. [PDF]

Bull Math Biol
Kahiya ET, Smutný T, Smutná L, Duintjer Tebbens J, Pávek P, Bernhauerová V.   +5 more
europepmc   +1 more source

Codeine and Metabolite Concentrations in the Breastfed Neonate

Pediatric Anesthesia, Volume 36, Issue 9, Page 1016-1022, September 2026.
ABSTRACT Analgesic effect from codeine is from its metabolite, morphine. Morphine is formed by the O‐demethylation of codeine and that enzyme is controlled by the cytochrome P450 2D6. More than 60 alleles in the CYP2D6 gene have been identified. This spectrum of polymorphism can be categorized into four groups: poor (PM), intermediate (IM), normal (NM),
Brian J. Anderson, Jacqueline A. Hannam
wiley   +1 more source

Continuous Subcutaneous Ketamine Infusion May Induce Tacrolimus and Sirolimus Clearance: A Case Report. [PDF]

Pharmacotherapy
Stojanova J, Murnion B, Burrows F, Carlos L, Mizuno T, Nadai T, Irie K, Helsby N, Muthiah K, Day R.   +9 more
europepmc   +1 more source

Plasma Lidocaine Concentrations During Intravenous Lidocaine Infusion Therapy in the Pediatric Population—A Scoping Review

Pediatric Anesthesia, Volume 36, Issue 9, Page 1041-1051, September 2026.
ABSTRACT Background Intravenous lidocaine therapy (IVLT) is often used in perioperative multimodal analgesia due to its analgesic, anti‐hyperalgesic, and anti‐inflammatory effects. In adults, IVLT doses of 1–2 mg/kg/h produce plasma concentrations of 1–2 μg/mL, within the presumed therapeutic range of 1–5 μg/mL.
McKenna Postles, Amanda Barton, Nicholas West, Gillian Lauder   +3 more
wiley   +1 more source

Obesity and Pharmacokinetic Variability: Implications for Cardiovascular Therapeutics. [PDF]

Eur Cardiol
Pitocco D, Cortelletti M, Petrucci G, Rocca B.   +3 more
europepmc   +1 more source

Transitioning from Transcriptomics to Proteomics: Enhancing Mechanistic Accuracy in PBPK Modeling via Absolute Protein Abundances

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 9, September 2026.
ABSTRACT Reliable physiologically based pharmacokinetic (PBPK) modeling depends on tissue‐specific expression profiles that reflect protein activities governing drug disposition. In PK‐Sim, existing expression databases rely on transcriptomics data. However, mRNA levels often exhibit limited correlation with protein abundance, frequently necessitating ...
Chen Ning, Alessandra Pugliano, Maximilian Winter, Keliang Wu, Pieter Annaert   +4 more
wiley   +1 more source