Results 161 to 170 of about 61,480 (319)
Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 3, March 2026.ABSTRACT Several publications have reported elevated clozapine concentrations in patients experiencing infections or inflammatory reactions. Proposed mechanisms include increased levels of pro‐inflammatory cytokines that may inhibit clozapine metabolism and enhanced binding of clozapine to the acute phase protein alpha‐1‐acid glycoprotein (AGP).
Ketil Arne Espnes +6 more
wiley +1 more source
Intestinal cell-specific vitamin D receptor (VDR)-mediated transcriptional regulation of CYP3A4 gene
, 2009 Petr Pávek +7 more
openalex +2 more sources
Assessment of CYP2C19, ABCB1, CYP3A5 Genes Polymorphisms’ and CYP3A4 Isoenzyme Activity Influence on Major Adverse Cardiovascular Events Among Patients with an Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention [PDF]
, 2017 Eric Rytkin +6 more
openalex +1 more source
Animal Research and One Health, Volume 4, Issue 1, Page 36-54, February 2026.Mechanisms of light in regulating the chick pineal clock. Abstract The circadian clock significantly impacts animal health and productivity, with light playing a crucial role in regulating circadian rhythms. However, the mechanisms behind light‐induced circadian transmission remain unclear, particularly in light‐sensitive avian species.
Yunlei Li +10 more
wiley +1 more source
A combined medication safety assessment of rivaroxaban with Tyrosine Kinase Inhibitors for cancer patients: focusing on CYP2J2 and CYP3A4 [PDF]
, 2021 Tingting Zhao +10 more
openalex +1 more source
British Journal of Clinical Pharmacology, Volume 92, Issue 2, Page 589-605, February 2026.Aims Resistance to the artemisinins and the artemisinin‐based combination therapy (ACT) partner drugs has developed in Southeast Asia, and artemisinin resistance has also emerged in eastern Africa. Triple ACTs (triple artemisinin‐based combination therapies, TACT), consisting of two partner drugs with different mechanisms of action and similar ...
Junjie Ding +24 more
wiley +1 more source
Feed-forward Regulation of Bile Acid Detoxification by CYP3A4 [PDF]
, 2004 Catherine Stedman +3 more
openalex +1 more source
Cirrhosis and Inflammation Regulates CYP3A4 Mediated Chemoresistance in Vascularized Hepatocellular Carcinoma-on-a-chip [PDF]
, 2022 Aliçan Özkan +5 more
openalex +1 more source
British Journal of Clinical Pharmacology, Volume 92, Issue 2, Page 606-611, February 2026.Mitotane is an adrenolytic drug with cytotoxic effects, registered for the treatment of advanced adrenocortical carcinoma (ACC), a rare but aggressive tumour type with a poor prognosis despite treatment. Recently, the oral multi‐kinase inhibitor cabozantinib has shown promising results as a potential second‐line treatment option.
Annemieke M. Peters van Ton +4 more
wiley +1 more source